黄芩水提液对肠炎模型小鼠空肠损伤修复的作用

doi:10.11843/j.issn.0366-6964.2020.02.021

Abstract

Abstract: This paper aimed to discuss the mechanism of the Scutellaria baicalensis water extraction on the damage and repair of jejunum in the model of enteritis mice. Thirty mice were randomly divided into control group, model group, low dose group, medium dose group and high dose group. Each mouse in the model group were fed with 0.4 mL·d^-1 enterotoxigenic Escherichia coli (3×10⁸ CFU·mL^-1) by the method of intragastric administration for 3 days to establish the model of enteritis. Each mouse in the low (0.3 g·d^-1), medium(0.6 g·d^-1) and high dose (1.2 g·d^-1) groups were pre-administered with the Scutellaria baicalensis water extraction for 6 days before establishing the enteritis model. Results showed that, compared with the control group, the mRNA expression of IL-6 in the jejunum of model group was extremely significantly increased (P<0.01), and the villous structure of jejunum was seriously damaged. However, the mRNA expression of MAPK in the model group that could repair the intestine damage did not change significantly. Compared with the model group, the mRNA expression of IL-6 in the jejunum of Scutellaria baicalensis water extraction groups were all extremely significantly decreased (P<0.01), as well as the mRNA expression of JNK/ERK (P<0.05). Moreover, the villous structures of mice in the Scutellaria baicalensis water extraction groups were all improved. In conclusion, Scutellaria baicalensis water extraction could repair the damage of jejunum by weakening intestinal inflammation and decreasing the mRNA expression of JNK and ERK in the model of enteritis mice.

Key words: mice, enteritis, Scutellaria baicalensis, damage and repair

CLC Number:

S853.7

LIU Xiaoxi, DONG Jie, LI Minxia, QIAN Huihui, ZHANG Jidong. Effect of the Scutellaria baicalensis Water Extraction on the Regulation of Jejunum Damage and Repair in the Model of Enteritis Mice[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(2): 392-398.

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Effect of the Scutellaria baicalensis Water Extraction on the Regulation of Jejunum Damage and Repair in the Model of Enteritis Mice

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