弓形虫致密颗粒蛋白的生物学功能研究进展

doi:10.11843/j.issn.0366-6964.2022.10.008

畜牧兽医学报 ›› 2022, Vol. 53 ›› Issue (10): 3345-3357.doi: 10.11843/j.issn.0366-6964.2022.10.008

弓形虫致密颗粒蛋白的生物学功能研究进展

郑晓楠^1,2, 李婷婷^2*, 王金磊^2,3, 郑文斌¹, 朱兴全^1,4*

1. 山西农业大学动物医学学院, 太谷 030801;
2. 中国农业科学院兰州兽医研究所, 家畜疫病病原生物学国家重点实验室, 兰州 730046;
3. 温州医科大学检验医学院、生命科学学院, 检验医学教育部重点实验室、温州市环境卫生微生物检验重点实验室, 温州 325035;
4. 云南农业大学动物医学院, 云南省高校兽医公共卫生重点实验室, 昆明 650201

收稿日期:2022-03-01 出版日期:2022-10-23 发布日期:2022-10-26
通讯作者: 朱兴全,主要从事动物寄生虫及其分子生物学研究,E-mail:xingquanzhu1@hotmail.com;李婷婷,主要从事动物寄生虫及其分子生物学研究,E-mail:litt866@163.com
作者简介:郑晓楠(1988-),女,山西榆社人,博士生,主要从事寄生虫分子生物学研究,E-mail:zhengxiaonan8889@126.com
基金资助:
国家自然科学基金（32002310；32172887）；国家重点研发计划项目（2021YFC2300800；2021YFC2300802）；山西省“1331工程”项目（20211331-13）；山西农业大学高层次人才科研专项项目（2021XG001）；云南省专家工作站（202005AF150041）

Research Progress on Biological Functions of Dense Granule Proteins of Toxoplasma gondii

ZHENG Xiaonan^1,2, LI Tingting^2*, WANG Jinlei^2,3, ZHENG Wenbin¹, ZHU Xingquan^1,4*

1. College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China;
2. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China;
3. Wenzhou Key Laboratory of Sanitary Microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China;
4. Key Laboratory of Veterinary Public Health of Higher Education of Yunnan Province, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China

Received:2022-03-01 Online:2022-10-23 Published:2022-10-26

摘要/Abstract

摘要： 刚地弓形虫（Toxoplasma gondii）是一种重要的人兽共患寄生原虫，具有中间宿主广泛、生活史复杂、传播方式多样、呈全球性分布等特点，可感染几乎所有的恒温动物，导致人兽共患的弓形虫病。弓形虫慢性感染约1/3的世界人口，对免疫缺陷患者、孕妇、孕畜的健康更是造成严重威胁。致密颗粒蛋白是由致密颗粒（弓形虫的一种亚细胞分泌器官）分泌的蛋白质，它们可通过操控宿主（细胞）基因表达、信号通路进而调控宿主细胞的免疫反应和细胞周期，并在蛋白质的转运和定位、营养物质的摄取、纳米管网络（IVN）的形成与稳定性的维持、逸出、慢性感染等生理过程中发挥重要作用。本文综述弓形虫致密颗粒蛋白基本生物学功能的最新研究进展，旨在为深入研究弓形虫的致病机制、鉴定新的抗弓形虫潜在药物靶点和疫苗候选分子提供借鉴。

关键词: 弓形虫, 弓形虫病, 致密颗粒蛋白, 生物学功能

Abstract: Toxoplasma gondii is an important zoonotic parasite with a wide range of intermediate hosts, complex life history, diverse modes of transmission and global distribution, which can infect almost all warm-blood animals, including humans, causing zoonotic toxoplasmosis. About one third of the world human population are chronically infected with T. gondii, which poses a serious health threat to immune deficiency patients, pregnant women and pregnant animals. Therefore, T. gondii is an important zoonotic parasite. Dense granule protein family secreted by the dense granules, one of the important subcellular secretory organelles of T. gondii, plays important roles in many biological processes, such as regulating the host cell cycle and immune response by modulating the signal pathways, gene expression, participating in the protein transport and localization, nutrient uptake, the formation and stability maintenance of intravacuolar network (IVN), as well as egress and chronic infection of T. gondii. In this review, the basic biological functions of the dense granule proteins are summarized in order to provide new research ideas for the pathogenesis of T. gondii, the discovery of potential drug targets against T. gondii and the development of anti-T. gondii vaccines.

Key words: Toxoplasma gondii, toxoplasmosis, dense granule proteins, biological function

中图分类号:

郑晓楠, 李婷婷, 王金磊, 郑文斌, 朱兴全. 弓形虫致密颗粒蛋白的生物学功能研究进展[J]. 畜牧兽医学报, 2022, 53(10): 3345-3357.

ZHENG Xiaonan, LI Tingting, WANG Jinlei, ZHENG Wenbin, ZHU Xingquan. Research Progress on Biological Functions of Dense Granule Proteins of Toxoplasma gondii[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3345-3357.

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弓形虫致密颗粒蛋白的生物学功能研究进展

Research Progress on Biological Functions of Dense Granule Proteins of Toxoplasma gondii

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