畜牧兽医学报 ›› 2020, Vol. 51 ›› Issue (5): 1158-1162.doi: 10.11843/j.issn.0366-6964.2020.05.027

• 研究简报 • 上一篇    下一篇

一例犬前肢血管周细胞瘤的病理及免疫组化分析

郑家三, 朱婷婷, 陈文文, 张佳韧   

  1. 黑龙江八一农垦大学动物科技学院, 大庆 163319
  • 收稿日期:2019-11-04 出版日期:2020-05-25 发布日期:2020-05-16
  • 作者简介:郑家三(1978-),男,黑龙江桦南人,副教授,博士,主要从事小动物普通病的研究,Tel:0459-6819206,E-mail:zjs3399@aliyun.com
  • 基金资助:
    中国博士后科学基金(2018M641889);黑龙江八一农垦大学科研启动计划(XDB201804);国家重点研究发展计划(2016YFD0501008);黑龙江八一农垦大学三横三纵支持计划(TDJH201903)

Pathological and Immunohistochemical Analysis of Hemangiopericytoma in a Dog Forelimb

ZHENG Jiasan, ZHU Tingting, CHEN Wenwen, ZHANG Jiaren   

  1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China
  • Received:2019-11-04 Online:2020-05-25 Published:2020-05-16

摘要: 血管周细胞瘤是一种软组织肉瘤,起源于毛细血管壁的周细胞。在本报道中,描述了一只11岁中华田园犬的左腿腕关节肿块。为确定肿块性质,采用影像学、细胞学和病理学检查加以诊断。X光检查显示肿瘤始于软组织,肿物界限清晰;细胞学检查显示细胞呈梭形,核仁明显,细胞核大小不一;病理组织学结果显示存在围绕血管的梭形细胞;免疫组织化学结果显示波形蛋白和α-SMA阳性表达,desmin和S-100阴性表达,肿瘤组织中PCNA阳性肿瘤细胞的数量大于25%,Masson trichrome染色显示肿瘤组织中胶原纤维的含量少。结合病理学及免疫组化确诊为血管周细胞瘤。

关键词: 犬, 血管周细胞瘤, 病理学, 免疫组织化学

Abstract: Hemangiopericytoma is a soft tissue sarcoma that originate from the pericytes of the capillary wall. In this study, we described a left radiocarpal joint mass in an 11-year-old female mixed-breed dog. Iconography, cytology, histopathology, and immunohistology were used to determine the nature of the mass. X-ray imaging showed that the tumor began in soft tissue and had clear boundaries; cytology showed that the cells were spindle-shaped, with obvious nucleoli and variably sized nuclei; histopathology revealed the presence of spindle cells surrounding blood vessels; immunohistochemistry was positive for vimentin and α-SMA, and negative for desmin and S-100. The number of PCNA positive tumor cells was more than 25%. Masson trichrome staining showed that the content of collagen fibers in tumor tissue was low. The diagnosis of hemangiopericytoma was confirmed by pathology and immunohistochemistry.

Key words: canine, hemangiopericytoma, pathology, immunohistochemistry

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