一例安德鲁貂尾尖软骨样脊索瘤的组织病理学观察及分析

doi:10.11843/j.issn.0366-6964.2023.09.038

畜牧兽医学报 ›› 2023, Vol. 54 ›› Issue (9): 3998-4002.doi: 10.11843/j.issn.0366-6964.2023.09.038

• 研究简报 • 上一篇

一例安德鲁貂尾尖软骨样脊索瘤的组织病理学观察及分析

龙美贞¹, 李浩运², 董玉慧¹, 南岳¹, 周向梅^1*

1. 中国农业大学动物医学院兽医公共卫生安全全国重点实验室, 北京 100193;
2. 中国农业大学动物医院, 北京 100193

收稿日期:2023-02-03 发布日期:2023-09-22
通讯作者: 周向梅,主要从事兽医病理学研究,E-mail:zhouxm@cau.edu.cn
作者简介:龙美贞(1998-),女,土家族,重庆人,硕士生,主要从事牛结核病防治研究,E-mail:1727293215@qq.com

A Case Report on Pathological Diagnosis and Analysis of Chondroid Chordoma in Anglo mink

LONG Meizhen¹, LI Haoyun², DONG Yuhui¹, NAN Yue¹, ZHOU Xiangmei^1*

1. National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;
2. China Agricultural University Veterinary Teaching Hospital, Beijing 100193, China

Received:2023-02-03 Published:2023-09-22

摘要/Abstract

摘要： 1例3岁雄性家养安德鲁貂,因尾尖有一缓慢生长的肿物而就诊,通过手术完全切除肿物,并对其进行组织病理学检查。结果显示,最后尾椎骨被一个由大的多角形细胞组成的分叶状肿瘤取代,肿瘤细胞的细胞质表现为高度空泡化(physaliferous cells),并可见胞质内PAS(Periodic Acid-Schiff)染色阳性颗粒。免疫组织化学显示细胞质对细胞角蛋白(cytokeratin,CK)和波形蛋白(vimentin)以及中枢神经特异蛋白(S-100)呈阳性。组织形态学特征和免疫组化结果与人的软骨样脊索瘤一致。本文描述了该病例的组织形态学特征和免疫组织化学结果,并回顾相关文献资料,可以为该肿瘤的诊疗和预后提供参考依据。

关键词: 安德鲁貂, 尾尖, 软骨样脊索瘤, 组织病理学, 免疫组织化学

Abstract: A 3-year-old, male domestic Anglo mink was presented with a slow-growing mass on the tail tip. The mass was completely removed by surgery. Histological examination performed on the mass revealed a lobulated neoplasm composed of large polygonal cells replaced the last coccygeal vertabra. The neoplastic cells had highly vacuolated cytoplasm (physaliferous cells) and intracytoplasmic Periodic Acid-Schiff-positive granules. Immunohistochemistry revealed cytoplasmic positivity for cytokeratin, vimentin and S-100. Histomorphological features and immunohistochemical results consistent with a chondroid chordoma of humans. This case report described Histomorphological features and immunohistochemical results in chondroid chordoma located at the tail of Anglo mink, and reviews the relevant literature, which can provide a reference for the diagnosis and prognosis of the tumor.

Key words: Anglo mink, tail, chondroid chordoma, histopathology, immunohistochemistry

中图分类号:

S857.4

龙美贞, 李浩运, 董玉慧, 南岳, 周向梅. 一例安德鲁貂尾尖软骨样脊索瘤的组织病理学观察及分析[J]. 畜牧兽医学报, 2023, 54(9): 3998-4002.

LONG Meizhen, LI Haoyun, DONG Yuhui, NAN Yue, ZHOU Xiangmei. A Case Report on Pathological Diagnosis and Analysis of Chondroid Chordoma in Anglo mink[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3998-4002.

参考文献

[1] TAUZIÉDE-ESPARIAT A, BRESSON D, POLIVKA M, et al. Prognostic and therapeutic markers in chordomas:a study of 287 tumours[J]. J Neuropathol Exp Neurol, 2016, 75(2):111-120.
[2] YUI T, OHMACHI T, MATSUDA K, et al. Histochemical and immunohistochemical characterization of chordoma in ferrets[J]. J Vet Diagn Invest, 2015, 77(4):467-473.
[3] MUNDAY J S, BROWN C A, RICHEY L J. Suspected metastatic coccygeal chordoma in a ferret (Mustela putorius furo)[J]. J Vet Diagn Invest, 2004, 16(5):454-458.
[4] STEFANSKI S A, ELWELL M R, MITSUMORI K, et al. Chordomas in Fischer 344 rats[J]. Vet Pathol, 1988, 25(1):42-47.
[5] BROCAL J, GAMINO V, GUEVAR J, et al. Imaging diagnosis-magnetic resonance imaging and histopathological features of a skull base chordoma in a cat[J]. Vet Radiol Ultrasound, 2017, 58(2):E11-E15.
[6] HADLOW W J. Vertebral chordoma in two ranch mink[J]. Vet Pathol, 1984, 21(5):533-536.
[7] COOPER T K, MURRAY K N, SPAGNOLI S, et al. Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio)[J]. Vet Pathol, 2015, 52(2):388-392.
[8] TAYLOR K R, GARNER M M, RUSSELL K, et al. Chordomas at high prevalence in the captive population of the endangered Perdido Key beach mouse (Peromyscus polionotus trissyllepsis)[J]. Vet Pathol, 2016, 53(1):163-169.
[9] SAUTIER L, GUILLIER D, COSTE M, et al. Coccygeal chordoma in a degu:case report and review of the literature[J]. J Vet Diagn Invest, 2019, 31(1):142-145.
[10] KURAMOCHI M, IZAWA T, HORI M, et al. Chordoma of the thoracic vertebrae in a Bengal tiger (Panthera tigris tigris)[J]. J Vet Med Sci, 2015, 77(7):893-895.
[11] DUNN D G, HARRIS R K, MEIS J M, et al. A histomorphologic and immunohistochemical study of chordoma in twenty ferrets (Mustela putorius furo)[J]. Vet Pathol, 1991, 28(6):467-473.
[12] CARMINATO A, MARCHIORO W, MELCHIOTTI E, et al. A case of coccygeal chondroid chordoma in a cat:morphological and immunohistochemical features[J]. J Vet Diagn Invest, 2008, 20(5):679-681.
[13] ISHIDA T, DORFMAN H D. Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull:can immunohistochemistry resolve the controversy?[J]. J Neurooncol, 1994, 18(3):199-206.
[14] HEALEY J H, LANE J M. Chordoma:a critical review of diagnosis and treatment[J]. Orthop Clin North Am, 1989, 20(3):417-426.
[15] SUNDARESAN N, GALICICH J H, CHU F C H, et al. Spinal chordomas[J]. J Neurosurg, 1979, 50(3):312-319.
[16] FLETCHER C D M, BRIDGE J A, HOGENDOORN P, et al. WHO classification of tumours of soft tissue and bone[M]. 5th ed. Lyon:International Agency for Research on Cancer, 2020.
[17] KARELE E N, PAZE A N. Chordoma:to know means to recognize[J]. Biochim Biophys Acta Rev Cancer, 2022, 1877(5):188796.
[18] ULICI V, HART J. Chordoma:a review and differential diagnosis[J]. Arch Pathol Lab Med, 2022, 146(3):386-395.
[19] VUJOVIC S, HENDERSON S, PRESNEAU N, et al. Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas[J]. J Pathol, 2006, 209(2):157-165.
[20] GEORGE B, BRESSON D, HERMAN P, et al. Chordomas:a review[J]. Neurosurg Clin North Am, 2015, 26(3):437-452.

一例安德鲁貂尾尖软骨样脊索瘤的组织病理学观察及分析

A Case Report on Pathological Diagnosis and Analysis of Chondroid Chordoma in Anglo mink

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