[1] HILTUNEN T,VIRTA M,LAINE A L.Antibiotic resistance in the wild:An eco-evolutionary perspective[J].Philos Trans R Soc Lond B Biol Sci,2017,372(1712):20160039.
[2] HERNANDO-AMADO S,BLANCO P,ALCALDE-RICO M,et al.Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials[J].Drug Resist Updat,2016,28:13-27.
[3] LAMAR J,PETZ M.Development of a receptor-based microplate assay for the detection of beta-lactam antibiotics in different food matrices[J].Anal Chim Acta,2007,586(1-2):296-303.
[4] AHMED S,NING J A,CHENG G Y,et al.Receptor-based screening assays for the detection of antibiotics residues-a review[J].Talanta,2017,166:176-186.
[5] BLANCO P,HERNANDO-AMADO S,REALES-CALDERON J A,et al.Bacterial multidrug efflux pumps:Much more than antibiotic resistance determinants[J].Microorganisms,2016,4(1):14.
[6] VERCHÈRE A,BROUTIN I,PICARD M.Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps[J].Sci Rep,2012,2(1):306.
[7] ADAM Y,TAYER N,ROTEM D,et al.The fast release of sticky protons:Kinetics of substrate binding and proton release in a multidrug transporter[J].Proc Natl Acad Sci U S A,2007,104(46):17989-17994.
[8] SCHMIDT T H,RAUNEST M,FISCHER N,et al.Computer simulations suggest direct and stable tip to tip interaction between the outer membrane channel TolC and the isolated docking domain of the multidrug RND efflux transporter AcrB[J].Biochim Biophys Acta,2016,1858(7 Pt A):1419-1426.
[9] RUIZ C,LEVY S B.Regulation of acrAB expression by cellular metabolites in Escherichia coli[J].J Antimicrob Chemother,2014,69(2):390-399.
[10] MANJASETTY B A,HALAVATY A S,LUAN C H,et al.Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity[J].J Struct Biol,2016,194(1):18-28.
[11] SATO T,YOKOTA S I,UCHIDA I,et al.Fluoroquinolone resistance mechanisms in an Escherichia coli isolate,HUE1,without quinolone resistance-determining region mutations[J].Front Microbiol,2013,4:125.
[12] LAWLER A J,RICCI V,BUSBY S J W,et al.Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA[J].J Antimicrob Chemother,2013,68(7):1551-1557.
[13] YOON E J,COURVALIN P,GRILLOT-COURVALIN C.RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii:Major role for AdeABC overexpression and AdeRS mutations[J].Antimicrob Agents Chemother,2013,57(7):2989-2995.
[14] RICHMOND G E,EVANS L P,ANDERSON M J,et al.The Acinetobacter baumannii two-component system AdeRS regulates genes required for multidrug efflux,biofilm formation,and virulence in a strain-specific manner[J].mBio,2016,7(2):e00430-16.
[15] CAPRA E J,LAUB M T.Evolution of two-component signal transduction systems[J].Annu Rev Microbiol,2012,66:325-347.
[16] CHANG T Y,HUANG B J,SUN J R,et al.AdeR protein regulates adeABC expression by binding to a direct-repeat motif in the intercistronic spacer[J].Microbiol Res,2016,183:60-67.
[17] LIN M F,LIN Y Y,LAN C Y.The role of the two-component system BaeSR in disposing chemicals through regulating transporter systems in Acinetobacter baumannii[J].PLoS One,2015,10(7):e0132843.
[18] TERZI H A,KULAH C,CIFTCI?H.The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa[J].World J Microbiol Biotechnol,2014,30(10):2681-2687.
[19] AGHAZADEH M,HOJABRI Z,MAHDIAN R,et al.Role of efflux pumps:MexAB-OprM and MexXY (-OprA),AmpC cephalosporinase and OprD porin in non-metallo-β-lactamase producing Pseudomonas aeruginosa isolated from cystic fibrosis and burn patients[J].Infect Genet Evol,2014,24:187-192.
[20] TIAN Z X,YI X X,CHO A,et al.CpxR Activates MexAB-OprM efflux pump expression and enhances antibiotic resistance in both laboratory and clinical nalB-type isolates of Pseudomonas aeruginosa[J].PLoS Pathog,2016,12(10):e1005932.
[21] KELLER R,ARIÖZ C,HANSMEIER N,et al.The Escherichia coli envelope stress sensor CpxA responds to changes in lipid bilayer properties[J].Biochemistry,2015,54(23):3670-3676.
[22] LIAO J L,SCHURR M J,SAUER K.The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms[J].J Bacteriol,2013,195(15):3352-3363.
[23] BALASUBRAMANIAN D,SCHNEPER L,MERIGHI M,et al.The regulatory repertoire of Pseudomonas aeruginosa AmpC β-lactamase regulator AmpR includes virulence genes[J].PLoS One,2012,7(3):e34067.
[24] MASEDA H,SAWADA I,SAITO K,et al.Enhancement of the mexAB-oprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator,MexT,of the mexEF-oprN efflux pump operon in Pseudomonas aeruginosa[J].Antimicrob Agents Chemother,2004,48(4):1320-1328.
[25] CHEN H,YI C Q,ZHANG J,et al.Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR[J].EMBO Rep,2010,11(9):685-690.
[26] SIVANESON M,MIKKELSEN H,VENTRE I,et al.Two-component regulatory systems in Pseudomonas aeruginosa:An intricate network mediating fimbrial and efflux pump gene expression[J].Mol Microbiol,2011,79(5):1353-1366.
[27] ALGUEL Y,LU D,QUADE N,et al.Crystal structure of MexZ,a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa[J].J Struct Biol,2010,172(3):305-310.
[28] CHEN W Z,WANG D,ZHOU W Q,et al.Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa[J].Mol Microbiol,2016,100(5):749-758.
[29] ALGUEL Y,MENG C X,TERÁN W,et al.Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials[J].J Mol Biol,2007,369(3):829-840.
[30] FERNANDEZ-ESCAMILLA A M,FERNANDEZ-BALLESTER G,MOREL B,et al.Molecular binding mechanism of TtgR repressor to antibiotics and antimicrobials[J].PLoS One,2015,10(9):e0138469.
[31] CHONG S Y,LEE K,CHUNG H S,et al.Levofloxacin efflux and smeD in clinical isolates of Stenotrophomonas maltophilia[J].Microb Drug Resist,2017,23(2):163-168.
[32] SÁNCHEZ M B.Antibiotic resistance in the opportunistic pathogen Stenotrophomonas maltophilia[J].Front Microbiol,2015,6:658.
[33] HERNÁNDEZ A,MATÉ M J,SÁNCHEZ-DÍAZ P C,et al.Structural and functional analysis of SmeT,the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF[J].J Biol Chem,2009,284(21):14428-14438.
[34] HERNÁNDEZ A,RUIZ F M,ROMERO A,et al.The binding of triclosan to SmeT,the repressor of the multidrug efflux pump SmeDEF,induces antibiotic resistance in Stenotrophomonas maltophilia[J].PLoS Pathog,2011,7(6):e1002103.
[35] WU C J,HUANG Y W,LIN Y T,et al.Inactivation of SmeSyRy two-component regulatory system inversely regulates the expression of SmeYZ and SmeDEF efflux pumps in Stenotrophomonas maltophilia[J].PLoS One,2016,11(8):e0160943.
[36] LIN Y T,HUANG Y W,LIOU R S,et al.MacABCsm,an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance,oxidative and envelope stress tolerances and biofilm formation[J].J Antimicrob Chemother,2014,69(12):3221-3226.
[37] BIALEK-DAVENET S,LAVIGNE J P,GUYOT K,et al.Differential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumoniae[J].J Antimicrob Chemother,2015,70(1):81-88.
[38] KÄLLMAN O,MOTAKEFI A,WRETLIND B,et al.Cefuroxime non-susceptibility in multidrug-resistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels[J].J Antimicrob Chemother,2008,62(5):986-990.
[39] VELEBA M,HIGGINS P G,GONZALEZ G,et al.Characterization of RarA,a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae[J].Antimicrob Agents Chemother,2012,56(8):4450-4458.
[40] SANTIAGO A E,YAN M B,TRAN M,et al.A large family of anti-activators accompanying XylS/AraC family regulatory proteins[J].Mol Microbiol,2016,101(2):314-332.
[41] KAO C Y,CHEN C A,LIU Y F,et al.Molecular characterization of antimicrobial susceptibility of Salmonella isolates:First identification of a plasmid carrying qnrD or oqxAB in Taiwan[J].J Microbiol Immunol Infect,2017,50(2):214-223.
[42] SRINIVASAN V B,RAJAMOHAN G.KpnEF,a new member of the Klebsiella pneumoniae cell envelope stress response regulon,is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance[J].Antimicrob Agents Chemother,2013,57(9):4449-4462.
[43] GOLPARIAN D,SHAFER W M,OHNISHI M,et al.Importance of multidrug efflux pumps in the antimicrobial resistance property of clinical multidrug-resistant isolates of Neisseria gonorrhoeae[J].Antimicrob Agents Chemother,2014,58(6):3556-3559.
[44] JOHNSON P J T,SHAFER W M.The transcriptional repressor,MtrR,of the mtrCDE efflux pump operon of Neisseria gonorrhoeae can also serve as an activator of "off Target" gene (glnE) expression[J].Antibiotics (Basel),2015,4(2):188-197.
[45] FOLSTER J P,DHULIPALA V,NICHOLAS R A,et al.Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae[J].J Bacteriol,2007,189(13):4569-4577.
[46] ZALUCKI Y M,DHULIPALA V,SHAFER W M.Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae[J].mBio,2012,3(6):e00446-12.
[47] MØLLER T S B,OVERGAARD M,NIELSEN S S,et al.Relation between tetR and tetA expression in tetracycline resistant Escherichia coli[J].BMC Microbiol,2016,16:39.
[48] RAMOS J L,MARTÍNEZ-BUENO M,MOLINA-HENARES A J,et al.The TetR family of transcriptional repressors[J].Microbiol Mol Biol Rev,2005,69(2):326-356.
[49] TANABE M,SZAKONYI G,BROWN K A,et al.The multidrug resistance efflux complex,EmrAB from Escherichia coli forms a dimer in vitro[J].Biochem Biophys Res Commun,2009,380(2):338-342.
[50] YAMANE K,WACHINO J I,SUZUKI S,et al.New plasmid-mediated fluoroquinolone efflux pump,QepA,found in an Escherichia coli clinical isolate[J].Antimicrob Agents Chemother,2007,51(9):3354-3360.
[51] HENG J,ZHAO Y,LIU M,et al.Substrate-bound structure of the E.coli multidrug resistance transporter MdfA[J].Cell Res,2015,25(9):1060-1073.
[52] LU S,ZGURSKAYA H I.MacA,a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC,binds lipopolysaccharide core specifically and with high affinity[J].J Bacteriol,2013,195(21):4865-4872.
[53] ROUQUETTE-LOUGHLIN C E,BALTHAZAR J T,SHAFER W M.Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae[J].J Antimicrob Chemother,2005,56(5):856-860.
[54] LEE E H,HILL S A,NAPIER R,et al.Integration Host Factor is required for FarR repression of the farAB-encoded efflux pump of Neisseria gonorrhoeae[J].Mol Microbiol,2006,60(6):1381-1400.
[55] LEUNG Y M,HOLDBROOK D A,PIGGOT T J,et al.The NorM MATE transporter from N.gonorrhoeae:Insights into drug and ion binding from atomistic molecular dynamics simulations[J].Biophys J,2014,107(2):460-468.
[56] LONG F,ROUQUETTE-LOUGHLIN C,SHAFER W M,et al.Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli[J].Antimicrob Agents Chemother,2008,52(9):3052-3060.
[57] COSTA S S,VIVEIROS M,AMARAL L,et al.Multidrug efflux pumps in Staphylococcus aureus:An update[J].Open Microbiol J,2013,7:59-71.
[58] TRUONG-BOLDUC Q C,DUNMAN P M,EIDEM T,et al.Transcriptional profiling analysis of the global regulator NorG,a GntR-like protein of Staphylococcus aureus[J].J Bacteriol,2011,193(22):6207-6214.
[59] TRUONG-BOLDUC Q C,HOOPER D C.Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus[J].J Bacteriol,2010,192(10):2525-2534.
[60] WALKER J N,CROSBY H A,SPAULDING A R,et al.The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis[J].PLoS Pathog,2013,9(12):e1003819.
[61] BIRUKOU I,SEO S M,SCHINDLER B D,et al.Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR[J].Nucleic Acids Res,2014,42(4):2774-2788.
[62] CHOUCHANI C,EL SALABI A,MARRAKCHI R,et al.First report of mefA and msrA/msrB multidrug efflux pumps associated with blaTEM-1 β-lactamase in Enterococcus faecalis[J].Int J Infect Dis,2012,16(2):e104-109.
[63] SCHWAIGER K,HÖLZEL C,BAUER J.Detection of the macrolide-efflux protein A gene mef(A) in Enterococcus faecalis[J].Microb Drug Resist,2011,17(3):429-432.
[64] CHANCEY S T,BAI X H,KUMAR N,et al.Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel (msr (D)) elements[J].PLoS One,2015,10(2):e0116254.
[65] CHANCEY S T,ZHOU X L,ZÄHNER D,et al.Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniae[J].Antimicrob Agents Chemother,2011,55(7):3413-3422.
[66] EL GARCH F,LISMOND A,PIDDOCK L J V,et al.Fluoroquinolones induce the expression of patA and patB,which encode ABC efflux pumps in Streptococcus pneumoniae[J].J Antimicrob Chemother,2010,65(10):2076-2082.
[67] BAYLAY A J,PIDDOCK L J V.Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator[J].J Antimicrob Chemother,2015,70(3):670-679.
[68] HUILLET E,VELGE P,VALLAEYS T,et al.LadR,a new PadR-related transcriptional regulator from Listeria monocytogenes,negatively regulates the expression of the multidrug efflux pump MdrL[J].FEMS Microbiol Lett,2006,254(1):87-94.
[69] JIANG X B,ZHOU L J,GAO D W,et al.Expression of efflux pump gene lde in ciprofloxacin-resistant foodborne isolates of Listeria monocytogenes[J].Microbiol Immunol,2012,56(12):843-846.
[70] GUÉRIN F,GALIMAND M,TUAMBILANGANA F,et al.Overexpression of the novel MATE fluoroquinolone efflux pump FepA in Listeria monocytogenes is driven by inactivation of its local repressor FepR[J].PLoS One,2014,9(9):e106340.
[71] PUTMAN M,VAN VEEN H W,DEGENER J E,et al.The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides,macrolides,streptogramins and tetracyclines[J].Microbiology,2001,147(Pt 10):2873-2880.
[72] ESPINOSA-URGEL M,SERRANO L,RAMOS J L,et al.Engineering biological approaches for detection of toxic compounds:A new microbial biosensor based on the Pseudomonas putida TtgR repressor[J].Mol Biotechnol,2015,57(6):558-564.
[73] HONG H,PARK W.TetR repressor-based bioreporters for the detection of doxycycline using Escherichia coli and Acinetobacter oleivorans[J].Appl Microbiol Biotechnol,2014,98(11):5039-5050.
[74] MELAMED S,NAFTALY S,BELKIN S.Improved detection of antibiotic compounds by bacterial reporter strains achieved by manipulations of membrane permeability and efflux capacity[J].Appl Microbiol Biotechnol,2014,98(5):2267-2277.
[75] HANSEN L H,FERRARI B,SØRENSEN A H,et al.Detection of oxytetracycline production by Streptomyces rimosus in soil microcosms by combining whole-cell biosensors and flow cytometry[J].Appl Environ Microbiol,2001,67(1):239-244. |