锰纳米佐剂的制备及生物学效应

doi:10.11843/j.issn.0366-6964.2024.08.011

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (8): 3374-3382.doi: 10.11843/j.issn.0366-6964.2024.08.011

锰纳米佐剂的制备及生物学效应

王梦迪²(), 王恒¹(), 鲁秀香¹, 王昱旻¹, 樊文杰¹, 姚晨¹, 刘鹏翔¹, 马延杰¹, 杨国宇¹^,²^,*()

1. 河南农业大学农业农村部动物生化与营养重点开放实验室, 郑州 450046
2. 河南牧业经济学院食品与生物工程学院, 郑州 450046

收稿日期:2023-09-04 出版日期:2024-08-23 发布日期:2024-08-28
通讯作者: 杨国宇 E-mail:mengdi.ok@163.com;771521561@qq.com;haubiochem@163.com
作者简介:王梦迪(1989-)，女，河南南阳人，博士，主要从事动物生理生化研究，E-mail：mengdi.ok@163.com
王恒(1999-)，男，河南安阳人，硕士生，主要从事动物生理生化研究，E-mail：771521561@qq.com
第一联系人：
王梦迪和王恒为同等贡献作者
基金资助:
河南省科技攻关(232102310381);河南牧业经济学院博士科研启动资金资助(2022HNUAHEDF033);国家重点研发计划项目子课题(2021YFD1301201)

Preparation of Nano-manganese and Its Biological Effects

Mengdi WANG²(), Heng WANG¹(), Xiuxiang LU¹, Yumin WANG¹, Wenjie FAN¹, Chen YAO¹, Pengxiang LIU¹, Yanjie MA¹, Guoyu YANG¹^,²^,*()

1. Key Open Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs, Henan Agricultural University, Zhengzhou 450046, China
2. College of Food and Biotechnology, Henan University of Animal Husbandry Economics, Zhengzhou 450046, China

Received:2023-09-04 Online:2024-08-23 Published:2024-08-28
Contact: Guoyu YANG E-mail:mengdi.ok@163.com;771521561@qq.com;haubiochem@163.com

摘要/Abstract

摘要：

锰作为生命活动中重要微量元素参与了多种生理过程。对于能量代谢、神经系统发育和免疫系统正常运行至关重要。与可溶性锰离子相比，纳米锰可维持锰离子在注射部位持续释放, 以诱导局部的免疫应答, 并增强树突状细胞(dendritic cells, DCs)对抗原的摄取, 促进DCs在体内活化与成熟。本文从纳米锰作用机制、制备方法、功能表征、纳米佐剂存在的问题和解决策略等方面进行综述，重点介绍了纳米锰作为疫苗佐剂的应用，并提出存在问题及解决策略。

关键词: 纳米锰, 疫苗佐剂, 研究进展

Abstract:

Manganese is an important trace element that participates in various physiological processes, including skeletal, reproductive, energy metabolism, and normal functioning of the nervous and immune systems. Compared with soluble manganese ions, nano-manganese can maintain the continuous release of manganese ions at the injection site, induce local immune responses, and enhance the cellular uptake of antigens by dendritic cells (DCs), promoting the activation and maturation of DCs in the body. This article reviews the relevant issues of nano-manganese from the perspectives of their mechanism of action, preparation methods, functional characterization, problems with nano adjuvants, and solutions. The application of nano-manganese as vaccine adjuvants was emphasized and the problems and solutions of nano-manganese were proposed.

Key words: nano-manganese, vaccines adjuvant, research progress

中图分类号:

S852.4

王梦迪, 王恒, 鲁秀香, 王昱旻, 樊文杰, 姚晨, 刘鹏翔, 马延杰, 杨国宇. 锰纳米佐剂的制备及生物学效应[J]. 畜牧兽医学报, 2024, 55(8): 3374-3382.

Mengdi WANG, Heng WANG, Xiuxiang LU, Yumin WANG, Wenjie FAN, Chen YAO, Pengxiang LIU, Yanjie MA, Guoyu YANG. Preparation of Nano-manganese and Its Biological Effects[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(8): 3374-3382.

图/表 3

参考文献 47

1	岳卓.铝佐剂的特性及其研究进展[J].中国生物制品学杂志,2016,29(12):1349-1354.
	YUEZ.Properties and advance in research of aluminium adjuvant[J].Chinese Journal of Biologicals,2016,29(12):1349-1354.
2	PENGY C,MENTZERA J,LIUG H,et al.Broad and strong memory CD4⁺ and CD8⁺ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19[J].Nat Immunol,2020,21(11):1336-1345. doi: 10.1038/s41590-020-0782-6
3	彭沙,夏宇飞,高晓冬.铝佐剂颗粒化乳液制备及其免疫效果研究[J].过程工程学报,2022,22(2):195-203.
	PENGS,XIAY F,GAOX D.Preparation and immunogenicity of alum-stabilized Pickering emulsion[J].The Chinese Journal of Process Engineering,2022,22(2):195-203.
4	WANGC H,LUJ B,DUW X,et al.Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection[J].Vaccine,2019,37(32):4477-4484. doi: 10.1016/j.vaccine.2019.06.078
5	WANGC,GUANY,LVM,et al.Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses[J].Immunity,2018,48(4):675-687. doi: 10.1016/j.immuni.2018.03.017
6	YANGG B,XUL G,CHAOY,et al.Hollow MnO₂ as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses[J].Nat Commun,2017,8(1):902. doi: 10.1038/s41467-017-01050-0
7	ZHAOZ,MAZ X,WANGB,et al.Mn²⁺ directly activates cGAS and structural analysis suggests Mn²⁺ induces a noncanonical catalytic synthesis of 2'3'-cGAMP[J].Cell Rep,2020,32(7):108053. doi: 10.1016/j.celrep.2020.108053
8	QIAON,WANGH R,XUY H,et al.A Mn-Al double adjuvant nanovaccine to induce strong humoral and cellular immune responses[J].J Control Release,2023,358,190-203. doi: 10.1016/j.jconrel.2023.04.036
9	PORANENM M,SALGADOP S,KOIVUNENM R,et al.Structural explanation for the role of Mn²⁺ in the activity of ø6 RNA-dependent RNA polymerase[J].Nucleic Acids Res,2008,36(20):6633-6644. doi: 10.1093/nar/gkn632
10	O'NEALS L,ZHENGW.Manganese toxicity upon overexposure: a decade in review[J].Curr Environ Health Rep,2015,2(3):315-328. doi: 10.1007/s40572-015-0056-x
11	ZHONGQ,MAOQ L,YANJ,et al.Real-time in situ monitoring of poly(lactide-co-glycolide) coating of coronary stents using electrochemical impedance spectroscopy[J].J Biomed Mater Res B Appl Biomater,2015,103(3):691-699. doi: 10.1002/jbm.b.33250
12	SONGT,LIAOY,ZUOQ H,et al.MnO₂ nanoparticles as a minimalist multimode vaccine adjuvant/delivery system to regulate antigen presenting cells for tumor immunotherapy[J].J Mater Chem B,2022,10(18):3474-3490. doi: 10.1039/D1TB02650J
13	朱真逸,宋万通,陈学思.高分子免疫佐剂材料[J].高分子学报,2023,54(5):534-549.
	ZHUZ Y,SONGW T,CHENX S.Polymeric immune adjuvant materials[J].Acta Polymerica Sinica,2023,54(5):534-549.
14	YUP,ZHANGX,WANGD L,et al.Shape-controlled synthesis of 3D hierarchical MnO₂ nanostructures for electrochemical supercapacitors[J].Cryst Growth Des,2009,9(1):528-533. doi: 10.1021/cg800834g
15	赵瑞波, 王宇馨, 孔祥东, 等. 一种磷酸锰纳米材料及其快速制备方法和应用: 中国, 202111177655. 2[P]. 2022-02-01.
	ZHAO R B, WANG Y X, KONG X D, et al. Manganese phosphate nanomaterial and rapid preparation method and application thereof: CN, 202111177655. 2[P]. 2022-02-01. (in Chinese)
16	ZHANGK,QIC,CAIK Y.Manganese-based tumor immunotherapy[J].Adv Mater,2023,35(19):e2205409. doi: 10.1002/adma.202205409
17	PETKARK C,PATILS M,CHAVHANS S,et al.An overview of nanocarrier-based adjuvants for vaccine delivery[J].Pharmaceutics,2021,13(4):455. doi: 10.3390/pharmaceutics13040455
18	FANN,CHENK P,ZHUR,et al.Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants[J].Sci Adv,2022,8(51):eabq3500. doi: 10.1126/sciadv.abq3500
19	SUNZ L,WANGZ Y,WANGT,et al.Biodegradable MnO-based nanoparticles with engineering surface for tumor therapy: simultaneous fenton-like ion delivery and immune activation[J].ACS Nano,2022,16(8):11862-11875. doi: 10.1021/acsnano.2c00969
20	HEQ B,ZHENGR X,MAJ C,et al.Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy[J].Biomater Res,2023,27(1):29. doi: 10.1186/s40824-023-00374-x
21	BENNETTS R,MCCARTYJ M,RAMANATHANR,et al.Safety and immunogenicity of PXVX0317, an aluminium hydroxide-adjuvanted chikungunya virus-like particle vaccine: a randomised, double-blind, parallel-group, phase 2 trial[J].Lancet Infect Dis,2022,22(9):1343-1355. doi: 10.1016/S1473-3099(22)00226-2
22	KUOT Y,LINM Y,COFFMANR L,et al.Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19[J].Sci Rep,2020,10(1):20085. doi: 10.1038/s41598-020-77077-z
23	LUOL,QINT,HUANGY F,et al.Exploring the immunopotentiation of Chinese yam polysaccharide poly(lactic-co-glycolic acid) nanoparticles in an ovalbumin vaccine formulation in vivo[J].Drug Deliv,2017,24(1):1099-1111. doi: 10.1080/10717544.2017.1359861
24	SHIY L,XUEJ T,JIAL Y,et al.Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide[J].Colloids Surf B Biointerfaces,2018,161,67-72. doi: 10.1016/j.colsurfb.2017.10.037
25	WANGW J,DINGX F,XUQ,et al.Zeta-potential data reliability of gold nanoparticle biomolecular conjugates and its application in sensitive quantification of surface absorbed protein[J].Colloids Surf B Biointerfaces,2016,148,541-548. doi: 10.1016/j.colsurfb.2016.09.021
26	GHALGAOUIA,DOUDINN,KELDERERE,et al.1, 4-Phenylene diisocyanide (PDI) interaction with low-coordinated gold sites: dissociation and adsorbate-induced restructuring[J].J Phys Chem C,2019,123(13):7870-7878. doi: 10.1021/acs.jpcc.8b07034
27	GAOZ L,XUW,ZHENGS J,et al.Orchestrated cytosolic delivery of antigen and adjuvant by manganese ion-coordinated nanovaccine for enhanced cancer immunotherapy[J].Nano Lett,2023,23(5):1904-1913. doi: 10.1021/acs.nanolett.2c04970
28	LVX J,HUANGJ,MINJ,et al.Multi-signaling pathway activation by pH responsive manganese particles for enhanced vaccination[J].J Control Release,2023,357,109-119. doi: 10.1016/j.jconrel.2023.01.078
29	GAOH J,SHIW D,FREUNDL B.Mechanics of receptor-mediated endocytosis[J].Proc Natl Acad Sci U S A,2005,102(27):9469-9474. doi: 10.1073/pnas.0503879102
30	NIUY T,YUM H,HARTONOS B,et al.Nanoparticles mimicking viral surface topography for enhanced cellular delivery[J].Adv Mater,2013,25(43):6233-6237. doi: 10.1002/adma.201302737
31	WANGC Y,XIAOY P,ZHUW W,et al.Photosensitizer-modified MnO₂ nanoparticles to enhance photodynamic treatment of abscesses and boost immune protection for treated mice[J].Small,2020,16(28):e2000589. doi: 10.1002/smll.202000589
32	BRITTONA A,COTZIASG C.Dependence of manganese turnover on intake[J].Am J Physiol,1966,211(1):203-206. doi: 10.1152/ajplegacy.1966.211.1.203
33	DAVISC D,ZECHL,GREGERJ L.Manganese metabolism in rats: an improved methodology for assessing gut endogenous losses[J].Proc Soc Exp Biol Med,1993,202(1):103-108. doi: 10.3181/00379727-202-43518
34	PEREST V,SCHETTINGERM R C,CHENP,et al."Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies"[J].BMC Pharmacol Toxicol,2016,17(1):57. doi: 10.1186/s40360-016-0099-0
35	SUNY Z,YINY,GONGL D,et al.Manganese nanodepot augments host immune response against coronavirus[J].Nano Res,2021,14(5):1260-1272. doi: 10.1007/s12274-020-3243-5
36	HOUL,TIANC Y,YANY S,et al.Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity[J].ACS Nano,2020,14(4):3927-3940. doi: 10.1021/acsnano.9b06111
37	ALMEIDAJ P M,LINA Y,FIGUEROAE R,et al.In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models[J].Small,2015,11(12):1453-1459. doi: 10.1002/smll.201402179
38	JINK,PARKJ,LEEJ,et al.Hydrated manganese(Ⅱ) phosphate (Mn₃(PO₄)₂·3H₂O) as a water oxidation catalyst[J].J Am Chem Soc,2014,136(20):7435-7443.
39	ZHOUS H,ZHANGR Y,YOUZ W,et al.pH-sensitive and biodegradable Mn₃(PO₄)₂·3H₂O nanoparticles as an adjuvant of protein-based bivalent COVID-19 vaccine to induce potent and broad-spectrum immunity[J].ACS Appl Mater Interfaces,2023,15(7):8914-8926.
40	NⅡKURAK,MATSUNAGAT,SUZUKIT,et al.Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo[J].ACS Nano,2013,7(5):3926-3938.
41	ZHANGR,WANGC G,GUANY K,et al.Manganese salts function as potent adjuvants[J].Cell Mol Immunol,2021,18(5):1222-1234.
42	LORENTZENC L,HAANENJ B,METÖ,et al.Clinical advances and ongoing trials of mRNA vaccines for cancer treatment[J].Lancet Oncol,2022,23(10):e450-e458.
43	YANS Q,LUOZ C,LIZ L,et al.Improving cancer immunotherapy outcomes using biomaterials[J].Angew Chem Int Ed Engl,2020,59(40):17332-17343.
44	XUJ,LVJ,ZHUANGQ,et al.A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy[J].Nat Nanotechnol,2020,15(12):1043-1052.
45	LIUC,LIUX,XIANGX C,et al.A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy[J].Nat Nanotechnol,2022,17(5):531-540.
46	KWAKYEG F,PAOLIELLOM M B,MUKHOPADHYAYS,et al.Manganese-induced parkinsonism and Parkinson's disease: shared and distinguishable features[J].Int J Environ Res Public Health,2015,12(7):7519-7540.
47	CHENGX T,ZHUZ,LIUY H,et al.Zeolitic imidazolate framework-8 encapsulating risedronate synergistically enhances osteogenic and antiresorptive properties for bone regeneration[J].ACS Biomater Sci Eng,2020,6(4):2186-2197.

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锰纳米佐剂的制备及生物学效应

Preparation of Nano-manganese and Its Biological Effects

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