铁蛋白纳米载体及其在生物医学领域的应用潜力

doi:10.11843/j.issn.0366-6964.2021.04.007

摘要/Abstract

摘要： 铁蛋白是广泛存在于几乎所有生命体中的储铁蛋白，具有储存和转化铁、维持细胞铁代谢平衡以及保护细胞免受氧化损伤等功能。铁蛋白亚基能够自组装成纳米笼，装载和运输各种金属、药物、显影剂等多种物质，并且铁蛋白具有易被修饰以及良好的生物相容性和靶向性等特点，使其成为生物医学领域应用潜力巨大的非病毒天然纳米材料。本文重点综述了铁蛋白的结构和生物学功能，以及基于铁蛋白搭建的纳米载体平台在疾病检测、纳米疫苗和药物载体等领域的研究进展及应用前景，旨在为基于铁蛋白纳米颗粒的相关研究提供参考。

关键词: 铁蛋白, 纳米载体, 结构与功能, 生物医药, 应用潜力

Abstract: Ferritin, an iron storage protein widely found in almost all living organisms, has some main functions of storing and transforming iron, maintaining the balance of cellular iron metabolism and protecting cells from oxidative damage. Ferritin can self-assemble into a spherical nanocage that carries and delivers various metals and a broad range of therapeutic and image agents. Moreover, ferritin has the characteristics of easy modification, good biocompatibility and targeting， and these make ferritin become a non-viral natural nanomaterial with great application potential in the field of biomedicine. This review highlights the structures and biological functions, the current work on ferritin as well as the application prospects based on ferritin nanocarrier platform in the field of disease detection, nanocarrier vaccine and drug carrier in order to provide reference for related researches.

Key words: ferritin, nanocarrier, structure and function, biomedicine, application potential

中图分类号:

R318

苏恺, 范葶莉, 宋勤叶. 铁蛋白纳米载体及其在生物医学领域的应用潜力[J]. 畜牧兽医学报, 2021, 52(4): 909-919.

SU Kai, FAN Tingli, SONG Qinye. Ferritin Nanocarrier and Its Application Potential in the Field of Biomedicine[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(4): 909-919.

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