RNA结合蛋白ELAVL1的功能及其调控病毒复制的研究进展

doi:10.11843/j.issn.0366-6964.2024.05.010

摘要/Abstract

摘要： 胚胎致死异常视觉蛋白1(embryonic lethal abnormal vision like 1, ELAVL1)，又被称为人类抗原R(human antigen R, HuR)，是一种典型的RNA结合蛋白(RNA binding protein，RBP)，通过与3'非翻译区(3' untranslated element, 3'UTR)的AU富含元件(AU-rich element，ARE)结合，在mRNA转录和翻译过程中发挥重要作用。ELAVL1的作用十分广泛，可调控肿瘤的发生发展、凋亡、迁移与侵袭，是许多癌症治疗的关键靶点，还能参与调节编码器官发育和组织稳态的蛋白质和mRNA的水平，也有许多研究表明，ELAVL1通过转录后调控和翻译后修饰来调节病毒复制。本文主要综述了ELAVL1的生物学特点、功能、调控机制及其在病毒复制过程中的调控作用，旨在为进一步研究ELAVL1与畜禽病毒复制之间互作的机制提供理论参考。

关键词: ELAVL1, RNA结合蛋白, 病毒, 调控机制

Abstract: Embryonic lethal abnormal vision like 1 (ELAVL1), also called human antigen R (HuR).It is a typical RNA binding protein (RBP) that binds to the AU-rich element (ARE) in the 3'untranslated element (3'UTR) and plays an important role in the process of mRNA transcription and translation. ELAVL1 has a wide range of functions and can regulate the occurence and development, apoptosis, migration, and invasion of tumors, making it the key target for many cancer treatments. It can also participate in the regulation of protein and mRNA levels encoding organ development and tissue homeostasis. Many studies have also shown that ELAVL1 regulates viral replication through post-transcriptional regulation and post-translational modification. This review summarizes the biological characteristics, functions, regulatory mechanisms of ELAVL1 and its regulatory role in the process of virus replication, aiming to provide a theoretical reference for further studies on the interaction between ELAVL1 and virus replication in livestock and poultry.

Key words: ELAVL1, RNA binding protein, virus, regulatory mechanism

中图分类号:

S855.3

余祖华, 高梦茹, 齐志颖, 张静雨, 何雷, 陈建, 丁轲. RNA结合蛋白ELAVL1的功能及其调控病毒复制的研究进展[J]. 畜牧兽医学报, 2024, 55(5): 1914-1925.

YU Zuhua, GAO Mengru, QI Zhiying, ZHANG Jingyu, HE Lei, CHEN Jian, DING Ke. Research Progress on the Function of RNA Binding Protein ELAVL1 and Its Regulation of Viral Replication[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1914-1925.

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