畜牧兽医学报 ›› 2023, Vol. 54 ›› Issue (7): 2732-2742.doi: 10.11843/j.issn.0366-6964.2023.07.007
陈鑫, 秦彤*
收稿日期:
2022-11-18
出版日期:
2023-07-23
发布日期:
2023-07-21
通讯作者:
秦彤,主要从事动物传染病病原学与流行病学研究,E-mail:qintong@caas.cn
作者简介:
陈鑫(1997-),男,山东德州人,硕士生,主要从事动物传染病病原学与流行病学研究,E-mail:1210729369@qq.com
基金资助:
CHEN Xin, QIN Tong*
Received:
2022-11-18
Online:
2023-07-23
Published:
2023-07-21
摘要: 基于信使RNA (messenger RNA,mRNA)的核酸疫苗是近年来兴起的一种新型疫苗技术。与传统疫苗相比,mRNA疫苗具有免疫原性强、安全性好、研发周期短、易于大规模生产等特点。过去的几年中,狂犬病、流感等传染病的多种mRNA疫苗进入了临床试验,并展现出良好的应用前景;在新冠肺炎疫情期间,mRNA疫苗的成功应用进一步验证了该平台,同时也开启了mRNA疫苗在传染病预防特别是兽医领域应用的闸门。本文将从mRNA疫苗的类型和结构、递送系统、作用机制以及临床应用等几个方面进行详细综述,以期为mRNA疫苗在传染病领域的深入研发和应用提供借鉴。
中图分类号:
陈鑫, 秦彤. mRNA疫苗及其在动物传染病中的研究展望[J]. 畜牧兽医学报, 2023, 54(7): 2732-2742.
CHEN Xin, QIN Tong. mRNA Vaccine and Its Research Prospect in Zoonotic Diseases[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2732-2742.
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