Kisspeptin/GPR54在哺乳动物繁殖上的研究进展

doi:10.11843/j.issn.0366-6964.2020.10.002

摘要/Abstract

摘要： Kisspeptin是Kiss1基因的产物，它能够与其G蛋白偶联受体GPR54结合，激活PLC/PKC/MAPK信号通路，从而在抑制肿瘤转移、调节动物机体繁殖及初情期的启动中发挥重要作用。Kisspeptin/GPR54不但在动物的下丘脑中表达，还在动物的垂体和性腺中广泛表达，并参与动物繁殖的调控。本文就kisspeptin/GPR54在下丘脑-垂体-性腺轴上调控动物繁殖及动物初情期启动上的最新研究进行概括归纳，重点强调了kisspeptin/GPR54在性腺上的定位与分布及其对配子发生可能的直接调控作用，同时总结了kisspeptin/GPR54相关研究面临的问题及未来的研究方向，这将为更好的开展kisspentin/GPR54在动物繁殖上的研究及应用提供帮助。

关键词: kisspeptin, GPR54, 繁殖, 性腺, 初情期

Abstract: Kisspeptin is the coding product of the Kiss1 gene, which can bind to its G protein-coupled receptor GPR54 and activate the PLC/PKC/MAPK signaling pathway, thereby playing an important role in inhibiting tumor metastasis, regulating animal reproduction and initiating the estrus. Kisspeptin/GPR54 is not only expressed in hypothalamus but also widely expressed in pituitary and gonads, which is involved in regulating reproduction of animals. We summarizes the latest researches about kisspeptin/GPR54 regulating reproduction and puberty initiation of animals in the hypothalamic-pituitary-gonadal axis. More importantly, the location and distribution of kisspeptin/GPR54 and its possible direct regulation on gametogenesis were highlighted in the gonads in this article. Besides, some problems faced in kisspeptin/GPR54 related research and its future research directions were concluded, which will better help the research and application of kisspentin/GPR54 in animal reproduction.

Key words: kisspeptin, GPR54, reproduction, gonad, puberty

中图分类号:

S814.1

杜旭旭, 梅山, 史远刚, 淡新刚. Kisspeptin/GPR54在哺乳动物繁殖上的研究进展[J]. 畜牧兽医学报, 2020, 51(10): 2341-2348.

DU Xuxu, MEI Shan, SHI Yuangang, DAN Xingang. Research Progress of Kisspeptin/GPR54 in Mammalian Reproduction[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(10): 2341-2348.

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