猪胰高血糖素样肽-2对结肠炎小鼠肠道损伤的保护作用研究

doi:10.11843/j.issn.0366-6964.2014.06.021

Abstract

Abstract:

As an intestinal-specific trophic factor，porcine glucagon-like peptide-2 (pGLP-2) could stimulate intestinal mucosal growth and reduce the severity of injury specificity.In order to provide a potential therapeutic agent for intestinal dysfunction and damage，the protective effects of pGLP-2 for colonic injury were measured in dextran sulfate sodium (DSS)-induced colitis in mice.Eighteen BALB/c mice were randomly assigned to three treatments for 10 days，mice of DSS group were fed 3% (w/v) DSS through their drinking water for 10 days from first day of experiment，mice of DSS+pGLP-2 group were extraperitoneally injected with pGLP-2 daily from day 3 to day 9 and drink 3% DSS.The water group received water normally.Results were as follows：DSS-induced colitis clearly decreased body weight and relative expression of zonula occludens-1 in the colon，which was significantly reduced by treatments with 3% DSS-pGLP-2.Administration of pGLP-2 to DSS-mice preserved normal colonic mucosal architecture and significantly decreased myeloperoxidase activity，the relative expression of interleukin-6，interleukin-10 and interferon-γ which induced by DSS.These results showed that pGLP-2 could reduce the severity of colonic injury in murine colitis.The potencies of this product highlight its potential as therapeutic agent for intestinal diseases in piglet.

Key words: pGLP-2, DSS, colitis, mice

CLC Number:

S856.4

QI Ke-ke，WU Jie，XU Zi-wei. The Therapeutic Effect of Porcine Glucagon-like Peptide-2 in a Murine Model of Experimental Colitis[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(6): 1011-1017.

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The Therapeutic Effect of Porcine Glucagon-like Peptide-2 in a Murine Model of Experimental Colitis

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