FGF7亚家族在小鼠毛囊第一生长周期的表达

doi:10.11843/j.issn.0366-6964.2018.03.007

Abstract

Abstract:

The aim of this study was to investigate the expression patterns of fibroblast growth factor (FGF) 7 subfamily (FGF7, FGF10 and FGF22) in the first hair follicle growth cycle of mice. The Real-time PCR, Western blot and immunohistochemistry were adopted to study the expression of FGF7/FGF10/FGF22 mRNA and protein in mice back skin on 1,3,5,8,16,18,20,23 postnatal days. The results of immunohistochemistry showed that FGF7 protein was mainly located in the inner root sheath and epidermal; FGF10 and FGF22 were widely located in various structure of hair follicle. The results of real-time PCR, Western blot as well as immunohistochemistry showed that the FGF7 level was the lowest in catagen(16 d).And relative level of FGF7 was significantly increased in telogen (18 d) and anagen (1-8, 20-23 d), compared to its expression in catagen (16 d) (P<0.05, P<0.01). The FGF10 level was the lowest in the end of anagen (8 d). And the relative level of FGF10 was significantly increased in prophase and metaphase of anagen (1-5, 20-23 d), catagen (16 d) and telogen (18 d) compared to its expression in the end of anagen (8 d) (P<0.05, P<0.01). The FGF22 level was the highest in catagen (16 d). And relative level of FGF22 was significantly decreased in telogen (18 d) and anagen (1-8, 20-23 d) compared to its expression in the catagen (16 d) (P<0.05;P<0.01). These results suggested that FGF7 and FGF10 might play an important role in inducing hair follicle into the new cycle during the development of hair follicle, and FGF22 might have an important effect on the induction of hair follicles into catagen.

CLC Number:

Q954.539

NIU Shu, CHENG Jia-qi, GAO Shu-yuan, CAO Xiao-rui, WU Jin-qiang, LU Na, YAN Rui-qin, HE Xiao-yan. Expression Profile of Fibroblast Growth Factor 7 Sub-family in the First Hair Follicle Cycle of Mice Skin[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(3): 515-524.

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Expression Profile of Fibroblast Growth Factor 7 Sub-family in the First Hair Follicle Cycle of Mice Skin

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