支原体分泌蛋白研究进展

doi:10.11843/j.issn.0366-6964.2017.09.002

Abstract

Abstract:

Mycoplasma is a critical pathogen of humans and animals. Due to lacking of highly effective drugs and vaccines, these diseases cause serious economic losses. The unknown pathogenesis and immunologic response restrict the development of novel drugs and vaccines. Secretory proteins are involved in direct communication between pathogens and hosts and usually considered as the key factors of virulence and immunity. Therefore they are potential targets of novel drugs and vaccines. But the study of secretory proteins of Mycoplasma has just started and only a few of Mycoplasma secretory proteins have been identified. In addition, the functions of secretory proteins in pathogenesis and immunity are mostly unknown. This paper reviewed the identified secretory proteins of Mycoplasma, their secretion pattern, and the methods used in related research, in order to provide some support to future study of Mycoplasma secretory proteins.

CLC Number:

S852.62

HU Gu-yue, ZHAO Gang, CHEN Ying-yu, GUO Ai-zhen. Progress on Secretory Proteins of Mycoplasma[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(9): 1572-1578.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.xmsyxb.com/EN/10.11843/j.issn.0366-6964.2017.09.002

https://www.xmsyxb.com/EN/Y2017/V48/I9/1572

References

[1] HE J, LIU M H, YE Z F, et al. Insights into the pathogenesis of Mycoplasma pneumoniae[J]. Mol Med Rep, 2016, 14(5):4030-4036.
[2] LABORDE S, DEGRAVE A, LEHMANN D, et al. Detection of Mollicutes in bioreactor samples by real-time transcription-mediated amplification[J]. Lett Appl Microbiol, 2010, 50(6):633-638.
[3] BROWN D R, WHITCOMB R F, BRADBURY J M. Revised minimal standards for description of new species of the class Mollicutes (division Tenericutes)[J]. Int J Syst Evol Microbiol, 2007, 57(11):2703-2719.
[4] SHIMIZU T, KIMURA Y, KIDA Y, et al. Cytadherence of Mycoplasma pneumoniae induces inflammatory responses through autophagy and toll-like receptor 4[J]. Infect Immun, 2014, 82(7):3076-3086.
[5] GUO M Y, WANG G Q, LV T T, et al. Endometrial inflammation and abnormal expression of extracellular matrix proteins induced by Mycoplasma bovis in dairy cows[J]. Theriogenology, 2014, 81(5):669-674.
[6] MEDINA J L, BROOKS E G, CHAPARRO A, et al. Mycoplasma pneumoniae CARDS toxin elicits a functional IgE response in Balb/c mice[J]. PLoS One, 2017, 12(2):e0172447.
[7] KAMMINGA T, KOEHORST J J, VERMEIJ P, et al. Persistence of functional protein domains in Mycoplasma Species and their role in host specificity and synthetic minimal life[J]. Front Cell Infect Microbiol, 2017, 7:31.
[8] GLINTON K, BECK J, LIANG Z, et al. Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion[J]. J Biol Chem, 2017, 292(16):6775-6785.
[9] SKALNIKOVA H, MOTLIK J, GADHER S J, et al. Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines[J]. Proteomics, 2011, 11(4):691-708.
[10] TAKEHARA M, TAKAGISHI T, SEIKE S, et al. Clostridium perfringens α-toxin impairs lipid raft integrity in neutrophils[J]. Biol Pharm Bull, 2016, 39(10):1694-1700.
[11] LIU J, CAI C G, GUO Q, et al. Secretory expression and efficient purification of recombinant anthrax toxin lethal factor with full biological activity in E. coli[J]. Protein Expr Purif, 2013, 89(1):56-61.
[12] NAVA P, VIDAL J E. The CpAL system regulates changes of the trans-epithelial resistance of human enterocytes during Clostridium perfringens type C infection[J]. Anaerobe, 2016, 39:143-149.
[13] BAE M J, RYU S, KIM H J, et al. Mycobacterium tuberculosis ESAT6 and CPF10 induce adenosine deaminase 2 mRNA expression in monocyte-derived macrophages[J]. Tuberc Respir Dis, 2017, 80(1):77-82.
[14] ORME I M. Tuberculosis vaccine types and timings[J]. Clin Vaccine Immunol, 2015, 22(3):249-257.
[15] NAMIKI K, GOODISON S, PORVASNIK S, et al. Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells[J]. PLoS One, 2009, 4(9):e6872.
[16] HOPFE M, HOFFMANN R, HENRICH B. P80, the HinT interacting membrane protein, is a secreted antigen of Mycoplasma hominis[J]. BMC Microbiol, 2004, 4:46.
[17] DAVIS K L, WISE K S. Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans[J]. Infect Immun, 2002, 70(3):1129-1135.
[18] ZHANG H, ZHAO G, GUO Y S, et al. Mycoplasma bovis MBOV_RS02825 encodes a secretory nuclease associated with cytotoxicity[J]. Int J Mol Sci, 2016, 17(5):628.
[19] DERRÉ-BOBILLOT A, CORTES-PEREZ N G, YAMAMOTO Y, et al. Nuclease A (Gbs0661), an extracellular nuclease of Streptococcus agalactiae, attacks the neutrophil extracellular traps and is needed for full virulence[J]. Mol Microbiol, 2013, 89(3):518-531.
[20] ZHAO J Q, PAN S, LIN L, et al. Streptococcus suis serotype 2 strains can induce the formation of neutrophil extracellular traps and evade trapping[J]. FEMS Microbiol Lett, 2015, 362(6):fnv022.
[21] GAURIVAUD P, BARANOWSKL E, PAU-ROBLOT C, et al. Mycoplasma agalactiae Secretion of β-(1→6)-glucan, a rare polysaccharide in prokaryotes, is governed by high-frequency phase variation[J]. Appl Environ Microbiol, 2016, 82(11):3370-3383.
[22] JORES J, MEENS J, BUETTNER F F R, et al. Analysis of the immunoproteome of Mycoplasma mycoides subsp. mycoides small colony type reveals immunogenic homologues to other known virulence traits in related Mycoplasma species[J]. Vet Immunol Immunopathol, 2009, 131(3-4):238-245.
[23] NASEEM S, MEENS J, JORES J, et al. Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type[J]. Vet Microbiol, 2010, 142(3-4):285-292.
[24] IVANKOV D N, PAYNE S H, GALPERIN M Y, et al. How many signal peptides are there in bacteria?[J]. Environ Microbiol, 2013, 15(4):983-990.
[25] ZHAO L Q, CHEN J Q, SUN J B, et al. Multimer recognition and secretion by the non-classical secretion pathway in Bacillus subtilis[J]. Sci Rep, 2017, 7:44023.
[26] TJALSMA H, ANTELMANN H, JONGBLOED J D H, et al. Proteomics of protein secretion by Bacillus subtilis:Separating the "secrets" of the secretome[J]. Microbiol Mol Biol Rev, 2004, 68(2):207-233.
[27] WANG G Q, CHEN H Q, XIA Y, et al. How are the non-classically secreted bacterial proteins released into the extracellular milieu?[J]. Curr Microbiol, 2013, 67(6):688-695.
[28] MILLER B K, ZULAUF K E, BRAUNSTEIN M. The sec pathways and exportomes of Mycobacterium tuberculosis[J]. Microbiol Spectr, 2017, 5(2), doi:10.1128/microbiolspec.
[29] BAGESHWAR U K, VERPLANK L, BAKER D, et al. High throughput screen for Escherichia coli twin arginine translocation (TAT) inhibitors[J]. PLoS One, 2016, 11(2):e0149659.
[30] CHEN J Q, ZHAO L Q, FU G, et al. A novel strategy for protein production using non-classical secretion pathway in Bacillus subtilis[J]. Microb Cell Fact, 2016, 15:69.
[31] TACCHI J L, RAYMOND B B A, JAROCKI V M, et al. Cilium adhesin P216(MHJ_0493) is a target of ectodomain shedding and aminopeptidase activity on the surface of Mycoplasma hyopneumoniae[J]. J Proteome Res, 2014, 13(6):2920-2930.
[32] MOMEN-HERAVI F, BALAJ L, ALIAN S, et al. Current methods for the isolation of extracellular vesicles[J]. Biol Chem, 2013, 394(10):1253-1262.
[33] MOMEN-HERAVI F, BALAJ L, ALIAN S, et al. Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles[J]. Front Physiol, 2012, 3:162.
[34] MEDVEDEVA E S, BARANOVA N B, MOUZYKANTOV A A, et al. Adaptation of mycoplasmas to antimicrobial agents:Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target[J]. Sci World J, 2014, 2014:150615.
[35] COCUCCI E, RACCHETTI G, MELDOLESI J. Shedding microvesicles:Artefacts no more[J]. Trends Cell Biol, 2009, 19(2):43-51.
[36] FÉVRIER B, RAPOSO G. Exosomes:Endosomal-derived vesicles shipping extracellular messages[J]. Curr Opin Cell Biol, 2004, 16(4):415-421.
[37] MATHIVANAN S, JI H, SIMPSON R J. Exosomes:Extracellular organelles important in intercellular communication[J]. J Proteomics, 2010, 73(10):1907-1920.
[38] CHERNOV V M, MOUZYKANTOV A A, BARANOVA N B, et al. Extracellular membrane vesicles secreted by mycoplasma Acholeplasma laidlawii PG8 are enriched in virulence proteins[J]. J Proteomics, 2014, 110:117-128.
[39] PAES J A, LORENZATTO K R, DE MORAES S N, et al. Secretomes of Mycoplasma hyopneumoniae and Mycoplasma flocculare reveal differences associated to pathogenesis[J]. J Proteomics, 2017, 154:69-77.
[40] COUTO M S R, KLEIN C S, VOSS-RECH D, et al. Extracellular proteins of Mycoplasma synoviae[J]. ISRN Vet Sci, 2012, 2012:802308.
[41] MONSEL A, ZHU Y G, GUDAPATI V, et al. Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases[J]. Expert Opin Biol Ther, 2016, 16(7):859-871.
[42] SAIA-CEREDA V M, AQUINO A, GUEST P C, et al. Two-dimensional gel electrophoresis:A reference protocol[J].Adv Exp Med Bio, 2017,974:175-182.
[43] SÓLYOMVÁRY A, ALBERTI Á, DARCSI A, et al. Optimized conversion of antiproliferative lignans pinoresinol and epipinoresinol:Their simultaneous isolation and identification by centrifugal partition chromatography and high performance liquid chromatography[J]. J Chromatogr B, 2017, 1052:142-149.
[44] MATAVELI L R V, ARRUDA M A Z. Expanding resolution of metalloprotein separations from soybean seeds using 2D-HPLC-ICP-MS and SDS-PAGE as a third dimension[J]. J Proteomics, 2014, 104:94-103.
[45] 郑彦. 不同代数永生化支气管上皮细胞分泌蛋白的分布特征[D]. 大连:大连医科大学, 2007.
ZHENG Y. The distribution of proteins in immortalized human bronchial epithelial cells[D]. Dalian:Dalian Medical University, 2007. (in Chinese)
[46] DEJUNG M, SUBOTA I, BUCERIUS F, et al. Quantitative proteomics uncovers novel factors involved in developmental differentiation of Trypanosoma brucei[J]. PLoS Pathog, 2016, 12(2):e1005439.
[47] CHAPMAN J R, BALASUBRAMANIAN D, TAM K, et al. Using quantitative spectrometry to understand the influence of genetics and nutritional perturbations on the virulence potential of Staphylococcus aureus[J]. Mol Cell Proteomics, 2017, 16(4 Suppl 1):S15-S28.
[48] 任冬梅. 猪肺炎支原体168株疫苗候选抗原蛋白Mhp168_116、Mhp168_341、Mhp168_322和Mhp168_549的原核表达及纯化[D]. 重庆:西南大学, 2014.
REN D M. The prokaryotic expression and purification of Mhp168_116, Mhp168_322, Mhp168_341, Mhp168_549 proteins of Mycoplasma hyopneumoniae vaccine candidate antigens[D]. Chongqing:Southwest University, 2014. (in Chinese)
[49] 李玲婷, 车海彦, 曹雪仁, 等. 海南木豆丛枝植原体质粒全序列测定及分析[J]. 热带作物学报, 2014, 35(7):1404-1408.
LI L T, CHE H Y, CAO X R, et al. The complete sequence analysis of a plasmid from pigeon pea witches-broom phytoplasma in Hainan[J]. Chinese Journal of Tropical Crops, 2014, 35(7):1404-1408. (in Chinese)
[50] 彭忠, 梁婉, 刘文静, 等. 多杀性巴氏杆菌HN06基因组分泌蛋白的预测与分析[J]. 动物医学进展, 2015, 36(12):6-10.
PENG Z, LIANG W, LIU W J, et al. Prediction and analysis of secreted proteins encoding genes in genome of Pasteurella multocida HN06[J]. Progress in Veterinary Medicine, 2015, 36(12):6-10. (in Chinese)

Progress on Secretory Proteins of Mycoplasma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	XIE Qingyun, XING Huixuan, YU Yanfei, YUAN Ting, XIONG Qiyan, XIONG Fuqiang, FENG Zhixin. Prokaryotic Expression, Polyclonal Antibody Preparation and Activity Identification of Helicase RuvA from Mycoplasma hyopneumoniae [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 271-281.
[2]	CHEN Qiwei, QUAN Heng, CHEN Shengli, LIU Donghui, YU Yongfeng, LI Caiyu, GONG Xiaowei, CHU Yuefeng. Functional Analysis of Biotin Uptake by the Energy-coupled Factor Transporter S Component MbBioY of Mycoplasma bovis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 282-289.
[3]	CHEN Yuetong, LIU Xiaohan, WANG Zhiyang, ZHAO Yuxin, ZHOU Tiezhong, HU Zengjin, ZHU Yue, WANG Shaohui, TIAN Mingxing, DING Siyu, QI Jingjing, YU Shengqing. Isolation, Identification, Pathogenicity and Drug Susceptibility of Mycoplasma gallisepticum from Dead Chicken Embryos in Large-scale Chicken Farms in Guangdong Province [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 290-299.
[4]	ZHONG Lemiao, LIU Binghui, WU Chunlin, WU Yijian. Preparation and Evaluation of Subunit Vaccine based on Adhesin Protein of Mycoplasma gallisepticum [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5171-5183.
[5]	WU Qi, ZHANG Yujuan, LIU Tong, XIN Jiuqing, XU Qingyuan. Research Progress of Mycoplasma bovis Adhesins and Adhesin-binding Proteins [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3206-3216.
[6]	JING Tingting, YIN Hao, HUANG Rong, LAN Shimei, LI Zhangcheng, YOU Liuchao, HAO Huafang, FU Lei, CHU Yuefeng. Prokaryotic Expression and Biological Function Analysis of Mycoplasma bovis 0580 Gene C-terminal Truncated [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2991-3001.
[7]	CHEN Yang, MENG Linchun, GUO Mengjiao, ZHANG Chengcheng, BO Zongyi, CHU Dianfeng, CAO Yongzhong, WU Yantao, ZHANG Xiaorong. Establishment and Preliminary Application of Indirect ELISA Method and HI Test for Detection of Mycoplasma Gallisepticum Antibody [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2062-2072.
[8]	WU Chunlin, ZHONG Lemiao, ZHAO Yan, LI Wenji, HUANG Xiaozi, WU Yijian. Transcriptomic Analysis on Responses of Chicken Trachea to Mycoplasma gallisepticum Strain MG-HY Infection [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2652-2662.
[9]	XU Lifeng, JIA Chenyu, CHEN Fuzai, FANG Mengyuan, LIU Xiaodan, CHEN Jilong, LI Xunliang. Isolation, Identification and Whole Genome Analysis of a Mycoplasma synoviae Strain from Chicken [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2663-2676.
[10]	ZENG Jinhong, XU Qingyuan, SHA Weiping, WU Shuang, LI Yuan, XIN Jiuqing, WANG Xiumei. Development and Application of Monoclonal Antibodies against Mycoplasma mycoides subsp.Mycoides [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2290-2299.
[11]	YIN Dejing, WU Yan, YUE Jun, YANG Peng, CHEN Jing, WANG Hui, ZHANG Shuangxiang, WANG Kaigong, CHENG Zhentao. Construction of Eukaryotic Expression Vector of N-terminal Gene of LppA Protein of Mycoplasma Mycoides subsp.Capri and Analysis of Its Immune Efficacy in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(3): 847-856.
[12]	LIU Lijia, WANG Yu, ZHANG Huanrong, WANG Jiabo. Whole Gene Analysis of 7 Mycoplasma synoviae Strains from Chicken [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2): 505-519.
[13]	YUE Yahui, XING Xiaoyong, WU Xiaochun, WEN Fengqin, ZHANG Hongyan, LONG Cuiqin, ZHANG Li, MA Haiyun, BAO Shijun. Expression of Elongation Factor Thermo Unstable of Mycoplasma synoviae WVU1853 Strain and Analysis of Its Adherence Characterization [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(2): 520-528.
[14]	WANG Jia, HUA Lizhong, LIU Beibei, ZHANG Lei, YUAN Ting, GAN Yuan, WEI Yanna, SHAO Guoqing, FENG Zhixin, XIONG Qiyan. Isolation, Identification and Pathogenicity of a Mycoplasma hyorhinis Strain [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(11): 3185-3193.
[15]	CHEN Shengli, HAO Huafang, JI Wenheng, CHU Yuefeng. Research Advances in Immunogenicity of Related Proteins of Animal Mycoplasmas [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(5): 1230-1237.