细胞死亡的新方式——铁死亡与铜死亡

doi:10.11843/j.issn.0366-6964.2024.02.005

摘要/Abstract

摘要： 铜死亡是最近新发现的一种调节性细胞死亡(regulated cell death,RCD)形式。这种死亡形式的主要原因是细胞内铜离子的聚集,这个过程靶向干扰三羧酸循环。虽然已有学者阐明了其基本分子机制,但是对于铜死亡的研究仍然存在许多需要探索的方面。相比之下,对铁离子过载诱导的铁死亡的研究已相对完善,本文以铁死亡研究为参照,对两种金属离子诱导的细胞死亡进行了全面综述。

关键词: 铁死亡, 铜死亡, 分子机制, 疾病状态

Abstract: Cuproptosis is a newly discovered form of regulated cell death (RCD), which is regulated by the accumulation of copper ions in cells, a process that is targeted to the tricarboxylic acid (TCA) cycle. Although the basic molecular mechanism has been elucidated by scholars, there are still many aspects to be studied. In contrast, ferroptosis induced by ferric ion overload is relatively well-studied. In this paper, the research on ferroptosis is used as a reference to compare with cuproptosis, and the cell death induced by two metal ions is reviewed thoroughly.

Key words: ferroptosis, cuproptosis, molecular mechanism, state of disease

中图分类号:

S852.3

王浩, 肖金龙, 沈珏, 赵金刚, 王帅, 刘根, 赵汝, 肖鹏, 高洪. 细胞死亡的新方式——铁死亡与铜死亡[J]. 畜牧兽医学报, 2024, 55(2): 461-470.

WANG Hao, XIAO Jinlong, SHEN Jue, ZHAO Jingang, WANG Shuai, LIU Gen, ZHAO Ru, XIAO Peng, GAO Hong. New Ways of Cell Death—Ferroptosis and Cuproptosis[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 461-470.

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