牛支原体逃避宿主免疫的研究进展

doi:10.11843/j.issn.0366-6964.2017.03.002

摘要/Abstract

摘要：

牛支原体（Mycoplasma bovis）是能够感染牛的一种重要的致病性支原体。牛支原体能够在宿主中持续存在并引起慢性疾病，包括肺炎、乳腺炎、耳炎、生殖障碍、关节炎、脑膜炎以及角膜结膜炎。由于临床上抗生素治疗效果不佳以及缺乏商业可用的敏感性诊断工具和有效的疫苗，牛支原体引起的疾病很难预防和控制。牛支原体能够造成长期感染的主要原因是其通过表面抗原高频率变异、规避吞噬细胞吞噬作用、入侵宿主细胞、形成生物膜以及调节宿主免疫应答等方法逃避宿主天然和适应性免疫。深入理解牛支原体的免疫逃避机制有助于研制更好的牛支原体诊断工具和疫苗，也将进一步促进牛支原体预防与控制技术的发展。

关键词: 牛支原体, 免疫逃避, 抗原变异, 规避吞噬, 生物膜, 免疫调节

Abstract:

Mycoplasma bovis is considered to be one of the important pathogenic agents of cattle. It can persist in the host and causes a series of chronic diseases including bronchopneumonia, mastitis, otitis, genital disorders, arthritis, meningitis or keratoconjunctivitis. Due to the resistance to antibotic therapy and the lake of commercially available diagnostic tools and effective vaccines, M. bovis-induced diseases are difficult to prevent and control. The main reason of persisitent infection caused by M. bovis is to evade the host innate and adaptive immunity through high frequent variation of membrane surface antigens, avoiding phagocytosis, cell invasion, biofilm formation and modulating host immune responses. Deeply understanding immune evasion mechanism of M. bovis is helpful to develop the new dignostic tools and novel vaccines, and it is also beneficial to prevent and control the diseases.

Key words: Mycoplasma bovis, immune evasion, antigenic variation, avoiding phagocytosis, biofilm, immunoregulation

中图分类号:

S852.62

季文恒，储岳峰，赵萍，陈胜利，郝华芳，王展慧，刘永生. 牛支原体逃避宿主免疫的研究进展[J]. 畜牧兽医学报, 2017, 48(3): 393-402.

JI Wen-heng, CHU Yue-feng, ZHAO Ping, CHEN Sheng-li, HAO Hua-fang,WANG Zhan-hui，LIU Yong-sheng. Advances in the Research of Immune Evasion by Mycoplasma bovis[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(3): 393-402.

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