盐酸头孢噻呋乳房注入剂对干乳期奶牛的安全性分析

doi:doi: 10.11843/j.issn.0366-6964.2016.08.027

Abstract

Abstract:

The aim of the study was to evaluate the safety of Ceftiofur Hydrochloride intramammary infusion (Dry Cow) for dairy cows.Twelve healthy lactating cows (include 6 primiparous cows and 6 multiparous cows) were selected for the research.There were 6 primiparous cows and 6 multiparous cows among them.All the cows had not been treated with any antibiotics by systemic or intramammary administration 30 days before.They were fed with food and water without any antibiotics and under normal conditions.All the cow’s udder regions were injected by the drug of Ceftiofur Hydrochloride intramammary infusions (Dry Cow)，and one piece of drug (specification：10 mL/500 mg) was only used for one udder region.The differences of rectal temperature，daily yielding，somatic cells number and the changes of pathogen in milk before and after administration were compared.The changes of clinical symptoms were observed all the time during the experiment.The results showed that there were no significant differences in rectal temperature，daily yielding，somatic cells number before and after administration（P＞0.05）.The number of pathogen in milk was reduced than before and there was not any new pathogen appeared at the same time.The results indicated that Ceftiofur Hydrochloride intramammary infusion (Dry Cow) have no adverse effects to dairy cows.It was safe to dairy cows when administrated according to the dosing regimen above.

CLC Number:

S859.796

WU Tong，ZHAO Lei-lei，ZHANG Dao-kang，XU Fei，ZHANG Ning，JIANG Shan-xiang，LIU Yi-ming. The Safety Evaluation of Ceftiofur Hydrochloride Intramammary Infusion (Dry Cow)[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(8): 1733-1738.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.xmsyxb.com/EN/doi: 10.11843/j.issn.0366-6964.2016.08.027

https://www.xmsyxb.com/EN/Y2016/V47/I8/1733

References

［1］HERINGSTAD B，KLEMETSDAL G，RUANE J.Clinical mastitis in Norwegian cattle：frequency，variance components，and genetic correlation with protein yield［J］. J Dairy Sci，1999，82(6):1325-1330.
［2］EBERHART R J.Management of dry cows to reduce mastitis［J］.J Dairy Sci，1986，69（6）：1721-1732.
［3］DINGWELL R T，LESLIE K E，DUFFIELD T F，et al.Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period［J］.J Dairy Sci，2003，86(1):159-168.
［4］BEVERLY A D，GERARD S I.The activity of ceftiofur sodium for Aeromonas spp. isolated from ornamental fish［J］.J Wildl Dis，1992，28(3):453-456.
［5］SALMON S A，WATTS J L，AARESTRUP F M，et al.Minimum inhibitory concentrations for selected antimicrobial agents organisms isolated from the mammary glands of dairy heifers in New Zealand and Denmark［J］.J Dairy Sci，1998，81(2):570-578.
［6］WATTS J L，SALMON S A，YANCEY R J，et al.Antimicrobial susceptibility of microorganisms isolated from the mammary glands of dairy heifers in New Zealand and Denmark［J］.J Dairy Sci，1995，78:1637-1648.
［7］CHRISTENSEN J M，SMITH B B，MURDANE D B.The disposition of five therapeutically important antimicrobial agents in flamas［J］.J Vet Pharmacol Ther，1996，19(6):431-438.
［8］JACOBSON G A，MARTINODS S，CUNNINGHAM C P.Determination of ceftiofur in bovine plasma by HPLC-DAD［J］.J Pharm Biomed Anal，2006，40:1249-1252.
［9］MATTHIAS B，ERHARD Z，MICHAEL P.Quantitative determination of ceftiofur-related residues in bovine raw milk by LC-MS/MS with electrospray ionization［J］.Eur Food Res Technol，2003，217:449-456.
［10］HOLYOAK G R，WANG S，LIU G，et al.The effects of ceftiofur sodium (Naxcel) on bovine oocyte and preimplantation embryonic development assessed by in vitro embryo production techniques［J］.J Vet Pharmacol Therap，1998，(21):92-98.
［11］KESLER D J，BECHTOL D J.Efficacy of sustained release needle-less ceftiofur sodium implants in treating calves with bovine respiratory disease［J］.Zentralbl Veterinarmed B，1999，46：25-35.
［12］NAVARRE C B，ZHANG L，SUNKARA G.Cefliofur distribution in plasma and joint fluid following regional limb injection in cattle［J］.J Vet Pharmacol Ther，2001，22:13-19.
［13］郭桂芳，梁先明，杨大伟，等.肌肉注射盐酸头孢噻呋混悬注射液对猪安全性试验［J］.中国兽医杂志，2010，46(11):66-68.
GUO G F，LIANG X M，YANG D W，et al.Satety experiment of pig muscle injection of Ceftiofur Hydrochloride［J］.Chinese Journal of Veterinary Medicine,2010，46(11):66-68.(in Chinese)
［14］罗永江，胡振英，罗超应，等.国产头孢噻呋钠的毒性试验［J］.动物医学进展，2005，26(11):72-74.
LUO Y J，HU Z Y，LUO C Y，et al.Toxicity experiment of ceftiofur sodium［J］.Progress in Veterinary Medicine，2005，26(11):72-74.(in Chinese)
［15］郑欢庆，黄玲利，周诗其，等.国产盐酸头孢噻呋急性毒性研究［J］.毒理学杂质，2008， 22(1):77-78.
ZHENG H Q，HUANG L L，ZHOU S Q，et al.Study on acute toxicity of domestic ceftiofur hydrochloride［J］.Journal of Toxicology，2008，22(1):77-78.(in Chinese)
［16］FDA.US Food and drug administration CVM GFI #49.Target animal safety and drug effectiveness studies for anti-microbial bovine mastitis products (lactating and non-lactating cow products)［S］.Revised April 4，1996.
［17］DINGWELL R T，LESLIE K E，SCHUKKEN Y H，et al.Association of cow and quarter-level factors at drying-off with new intramammary infections during the dry period［J］.Prev Vet Med，2004，(63):75-89.

[1]	CHEN Yang, WANG Yueli, CHEN Shiqi, LI Nanxin, ZHANG Wei, SHU Gang, XU Funeng, LI Haohuan, LIN Juchun, FU Hualin. Intestinal Absorption Characteristics of Florfenicol based on Oligopeptide Transporters [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1240-1248.
[2]	YANG Yanbei, XU Jing, LIU Wanping, TAO Aini, FENG Yulin, SUN Yong, WANG Chuang, LIU Jian. Effects of Low-concentration Azitromycin on Protein Expression, Capsular Polysaccharides and Drug Susceptibility of Streptococcus suis Type 2 [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 757-765.
[3]	CHEN Chaoqun, CHEN Jiali, ZHOU Xuanyi, WU Xue, WANG Jincheng, HUANG Anxiong, HAO Haihong. Establishment of Epidemiological Cut-off Values and Determination of Drug Resistance of Haemophilus parasuis with β-lactam Drugs [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(11): 3234-3245.
[4]	ZHAO Jiaqi, WEN Yongli, AN Yajing, LI Ziqian, QI Peisen, LI Qiang, HOU Dingchao. Response of Antibiotic Resistance Genes (ARGs) in Rumen of Yak to Three Exogenous Stimulating Factors [J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(5): 1126-1137.
[5]	XU Xinyao, DONG Na, LI Xinran, YANG Yang, WANG Zhihua, SHAN Anshan. Effect of Different Hydrophobic Amino Acids on Biological Activity of Alpha Helix Antimicrobial Peptides [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(4): 791-801.
[6]	ZHENG Ya-ni, GAO Xiu-ge, LIU Xiao-xiao, TENG Pei, JI Hui, JIANG Shan-xiang. Preliminary Research of Toxic Effects and Mechanisms of Salinomycin on Chicken Primary Cardiomyocytes [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(4): 740-751.
[7]	ZHANG Jing-yan, WANG Lei, LI Jian-xi, ZHANG Hong, ZHANG Kai, YANG Zhi-qiang, WANG Xue-zhi, QIN Zhe, MENG Jia-ren. Development and Performance of ELISA Kit for Rapid Detection of Olaquindox in Feed [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(8): 1297-1304.
[8]	NI Heng-jia,HUANG Xian-hui,HE Li-min,FANG Bing-hu,ZHAO Yong-da. Determination of Tulathromycin Residues in Swine Tissues [J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2011, 42(4): 557-561.

The Safety Evaluation of Ceftiofur Hydrochloride Intramammary Infusion (Dry Cow)

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Recommended Articles

Metrics

Comments