| ［1］MOODY J, HICKOK J, SEPTIMUS E. Infection prevention practices in adult ICUs in a large community hospital system experiencing sustained reduction in healthcare-associated (HA) MRSA infections［J］. Am J Infect Control, 2011, 39(5):E94.
［2］STEFANI S, CHUNG D R, LINDSAY J A, et al. Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods［J］. Int J Antimicrob Agents, 2012, 39(4):273-282.
［3］金春梅，朴美花，许顺姬，等. 耐甲氧西林金黄色葡萄球菌的耐药性分析［J］.中华医院感染学杂志，2013，23(13):3238-3242.
［4］ZHANG L, RAVIPATI A S, KOYYALAMUDI S R, et al. Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs［J］. Asian Pac J Trop Med, 2013, 6(9):673-681.
［5］CUSHNIE T P, LAMB A J. Recent advances in understanding the antibacterial properties of flavonoids［J］. Int J Antimicrob Agents, 2011,38(2):99-107.
［6］CHEN C H, HUANG T S, WONG C H, et al. Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells［J］. Food Chem Toxicol, 2009, 47(3) :638-644.
［7］OGURA T. A high contrast method of unstained biological samples under a thin carbon film by scanning electron microscopy［J］. Biochem Biophys Res Commun, 2008, 377(1): 79-84.
［8］SULLIVAN D M, GLISSON B S, HODGES P K, et al. Proliferation dependence of topoisomerase Ⅱ-mediated drug action［J］. Biochemistry, 1986, 25(8):2248-2256.
［9］WEBB M R, EBELER S E. A gel electrophoresis assay for the simultaneous determination of topoisomerase I inhibition and DNA intercalation［J］. Anal Biochem, 2003, 321(1):22-30.
［10］廖见培．DNA与小分子药物相互作用的研究［D］．长沙：湖南大学，2001．
［11］SCHWALM III N D, VERGHESE B, KNABEL S J. A novel multiplex PCR method for detecting the major clonal complexes of MRSA in nasal isolates from a Pennsylvania hospital［J］. J Microbiol Methods, 2011, 86(3):379-382.
［12］云宝仪, 周磊, 谢明杰，等.黄芩素抑菌活性及其机制的初步研究［J］.药学学报，2012，47(12):1587-1592.
［13］CORNEO G, POGLIANI E, BIASSONI D, et al. Inhibition of DNA restriction enzyme digestion by anthracyclines［J］.Ric Clin Lab , 1988, 18(1):19-22.
［14］CUSHNIE T P, LAMB A J. Antimicrobial activity of flavonoids［J］. Int J Antimicrob Agents, 2005, 26(5):343-356.
［15］余琼．抗耐甲氧西林金黄色葡萄球菌（MRSA）天然产物的筛选及研究［D］．重庆：西南大学，2012．
［16］闻平，俞晓丽，陈蕾，等，黄芩素对耐甲氧西林金黄色葡萄球菌的体外抗菌活性研究［C］//现代化中药制剂发展与中药药理学研究交流会论文集. 北京，中华中医药学会，2009：102-104.
［17］GENTRY A C, OSHEROFF N. Encyclopedia of Biological Chemistry［M］. Nashville: Vanderbilt University School of Medicine Press. 2013：157-168.
［18］NADAL M. Reverse gyrase: An insight into the role of DNA-topoisomerases［J］. Biochimie, 2007, 89(4):447-455.
［19］PATRA N, DE U, KANG J A, et al. A novel epoxypropoxy flavonoid derivative and topoisomerase Ⅱ inhibitor, MHY336, induces apoptosis in prostate cancer cells［J］. Eur J Pharmacol, 2011, 658(2-3):98-107.
［20］SHIOMI K, KURIYAMA I, YOSHIDA H, et al. Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation［J］. Food Chem, 2013,139(1-4):910-918.
［21］SCHMIDT F, KNOBBE C B, FRANK B, et al. The topoisomerase Ⅱ inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines［J］. Oncol Rep, 2008,19(4):1061-1066.
［22］CANTERO G, CAMPANELLA C, MATEOS S, et al. Topoisomerase Ⅱ inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin［J］. Mutagenesis, 2006, 21(5):321-325.
［23］GRYNBERG N F, CARVALHO M G, VELANDIA J R, et al. DNA topoisomerase inhibitors: biflavonoids from Ouratea species［J］. Braz J Med Biol Res, 2002, 35(7):819-822.
［24］FORTERRE P, GRIBALDO S, GADELLE D, et al. Origin and evolution of DNA topoisomerases［J］. Biochimie, 2007, 89(4):427-446. |
