Abstract: The objective of this study was to explore the status of poultry populations’ highly pathogenic avian influenza and its range developing risk. Integrated with the data mining techniques and theory of risk assessment of OIE (Organisation Mondiale de la Santé Animale),combined with the application of the methods of ecological pattern analysis and Bernoulli statistical model, the risk status of highly pathogenic avian influenza and its range expansion trend were derived since its first reported in 2004 in China. Results of analysis showed:(1)China has a very big host populations of poultry in certain given geographical regions, characterized by its complex raising & feeding pattern & mode, and diversified varieties, which make the consecutive occurrences of HPAI possible, and thereof entailed the bigger challenges for HPAI risk control. (2)The occurrences of HPAI in China featured by its significant tempospatial patterns, mainly characterized by its seasonalregional and specified host population occurrences, which indicted the importance of scientifically regional risk management and regional cooperation. (3)In risk developing trend, due to the regionalnational and international occurrences of HPAI, and existence of larger exposure host populations, make the further risk of HPAI infection and expansion possible in given region. (4)In risk predictions, Bernoulli statistical model integrated with geographical informational techniques were applied, result showed that there may be 210 times of HPAI occurrences with 90% confidence interval (CI) in 2008,6 times of HPAI occurrences were most likely, and poultry populations in southern part of China may be exposed at possible risk. There exist a highly likelihood for the reoccurrences of HPAI among poultry populations in China in future.