ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2005, Vol. 36 ›› Issue (4): 362-364.doi:

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Effect of Cadmium on DNA Damage in Splenic Lymphocytes of Chicken

LI Jin-long;XIONG Yong-zhong;XU Shi-wen;WANG Xiu-rong;LI Shu
  

  1. 1.Department of Veterinary Medicine, Northeast Agricultual University, Harbin 150030,China;2. Animal Influenza Laboratory of Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of CAAS, Harbin 150001, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2005-04-25 Published:2005-04-25

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Abstract: Quantative analysis of DNA fragmetation assay and alkaline single cell gel electrophoresis test were used to detect DNA damage of chicken splenic lymphocytes, cultured in vitro, which was induced by cadmium. The results showed that cadmium with the concentration of 10 μmol/L can induce DNA damage of chicken splenic lymphocytes obviously, which showed timedependent model. It demonstrated that DNA damage of lymphocytes induced by cadmium may be one of important mechanisms of avian immunotoxicity on cadmium.