ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2012, Vol. 43 ›› Issue (5): 821-825.doi:

• 临床兽医 • Previous Articles     Next Articles

Effect of Atipamezole on the Expression of Fos Protein Induced by Specificity Anesthetic for Miniature Pigs in the Rat Cerebral Cortex

YIN Baishuang1,2, SHI Xingxing1, LI Xiaobo1, LI Zhiqiang1,
FAN Honggang 1, GAO Li1, WANG Hongbin1*   

  1. 1. College of Animal Medicine, Northeast Agricultural University, Harbin 150030, China; 2. Department of Animal Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2012-05-28 Published:2012-05-28
  • Contact: WANG Hongbin

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Abstract: The research was conducted to investigate relationship atipamezole woke up rat anesthetized by XFM to cfos oncogene, by study on effect of atipamezole on the expression of Fos protein induced by XFM in the rat cerebral cortex. 72 SD rats were divided randomly into XFM group, XFM add atipamezole group, XFM add saline group. The content of cfos protein in cerebral cortex was measured by western blot. The Fos protein contents were obviously increased in the XFM anesthesia group as compared with 10 min after XFM administrated (P<0.01 or P<0.05). The Fos protein contents was never obviously changed after saline administrated as compared with control group (P>0.05). The Fos protein contents was significantly decreased after atipamzole administrated as compared with control group (P<0.05 or P<0.01). These results indicated that atipamezole palinesthesia action was concerned with cfos oncogene in cerebral cortex. Atipamzole attenuates expression of Fos protein induced by XFM in the rat cerebral cortex, it may be an important mechanism of atipamzole wake up rat anaesthetized by XFM.