Abstract: To supply the biological data of Zmu-1：DHP guinea pig，the fragmentation reaction of the sensitized mast cell,the activity of total complement,the phagocytic and oxidative burst function of polymorphonuclear leukocytes,the sensitivity to FMDV in different guinea pig were studied by attacking mast cell by antigen,complement CH50,LCM and virus infection．The results showed that the fragmentation proportion of the mast cell in Zmu-1：DHP guinea pig was significantly lower than other strain（P<0.01），the content of complement of the strain was higher（P<0.01），the phagocytic rate of polymorphonuclear leukocytes of the strain was higher（P<0.05），but the oxidative burst activity of the strain was lower（P<0.01）than that of others. And 100% sensitivity to FMDV in Zmu-1：DHP guinea pig was presented．It is indicated that the strain appears the new biological character，and possesses the higher value in application．