Abstract: This study was designed to investigate the effect of ADSL, GARS-AIRS-GART and combination genotypes of ADSL and GARSAIRSGART on IMP content in chicken meat. Five chicken breeds, including Recessive White, Silkies, Baier, Tibetan and Xiaoshan chickens were used. The primers for the exon2 in ADSL gene and 5′UTR region in GARS-AIRS-GART gene were designed and the SNPs were detected by PCR-SSCP method and DNA sequencing. Two SNPs were detected in exon2 of ADSL gene and 5′UTR region of GARS-AIRS-GART gene separately. The least square analysis showed that TT genotype birds had greatly significant higher IMP content than CC (P＜0.01) and significant higher than CT (P＜0.05) genotype birds, TC genotype birds also had a little higher IMP content than CC genotype birds, but the difference was not significant in ADSL gene TT genotype birds had significant higher IMP content than CC and CT genotype birds (P＜0.05), TC genotype birds also had a little higher IMP content than CC genotype birds, but the difference was not significant in GARSAIRSGART gene. The combination genotypes of ADSL and GARS-AIRS-GART genes also had significant effect on IMP content. The IMP content of the individuals with TTTT combination genotype was 1.584 mg/g higher than the individuals with CCCC combination genotype. Therefore we putatively drew the conclusion that the combination genotypes of ADSL and GARSAIRSGART gene could be used as the molecular genetic marker to select the chicken for meat quality traits.