ACTA VETERINARIA ET ZOOTECHNICA SINICA

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Effects of the Specificity Antagonist for Miniature Pigs Combined Anaesthetic on the Transcription of c-jun Gene mRNA in the Hippocampus of Rats Anesthetized with XFM

LI Xiao-bo1, YIN Bai-shuang1, 2, LI Zhi-qiang1, SHI Xing-xing1, FAN Hong-gang1, WANG Hong-bin1*   

  1. 1. College of Animal Medicine, Northeast Agricultural University, Harbin 150030, China;
    2. Department of Animal Medicine, Jilin Agricultural Science and Technology College, Jilin 132101, China
  • Received:2012-03-19 Online:2012-10-25 Published:2012-10-25

Abstract:  To explore the antagonism mechanism of the specificity antagonist for miniature pigs combined anaesthetic, the effect of the specificity antagonist on the c-jun gene transcription in the hippocampus of rats anesthetized with XFM was studied in this experiment. Ninety adult SD rats were divided randomly into three groups: XFM group, XFM add saline group and XFM add the specificity antagonist group. Each group consists of five subgroups, and samples were collected at different time points. The transcription of c-jun gene mRNA in every sample was detected with real time PCR. The result showed that The c-jun gene mRNA contents in each time point of the XFM group were obviously increased as compared with 0 min (P<0.01). There were no significant effect of injection of saline after XFM administrated on the c-jun gene mRNA transcription (P>0.05). The level of c-jun gene mRNA transcription after the specificity antagonist administrated was significantly lower than XFM group (P<0.01 or P<0.05). These results indicated that the specificity antagonist for miniature pigs combined anaesthetic attenuates the c-jun gene mRNA transcription in the hippocampus of rats induced by XFM, this may be related to the antagonism mechanism of the specificity antagonist for miniature pigs’ combined Anaesthetic.

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