ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2007, Vol. 38 ›› Issue (10): 1102-1108.doi:

• 基础兽医 • Previous Articles     Next Articles

Expression of NGF and TrKA in Developing Dorsal Root Ganglia of Goat Fetus

QING Su-zhu;LIN Ji-mao;XU Yong-ping;ZHANG Yong   

  1. College of Animal Science and Technology, Northwest A & F University, Yangling 712100,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-25 Published:2007-10-25

Abstract: The dorsal root ganglia (DRG) of goat fetus formed before 6th embryonic week, but the morphology of neurons inside ganglia were not very distinct until 8th embryonic week. The increase of ganglion volume mainly lied in growth of neurons and increasing of nerve fibers and neuroglia cells, but not lied in marked increase of neurons in number. Neurons could be divided into dark subpopulation and bright subpopulation according to their shape and staining extent, or three subpopulation—large size, medial size and small size according to cellular diameter. NGF and TrkA immunoreactivity were present in DRG of goat fetus. NGF-IR mainly localized in cytoplasm of three subpopulation, especially after 14th embryonic week; TrkA-IR occurred after 10th embryonic week, and were mainly distributed in cytoplasm and nucleus of medial-sized and smallsized neurons. No TrkA-IR could be detected on large-sized neurons, but TrkA immunostaining distributed in satellite cells surronding large-sized neurons The results suggested that NGF play an important role both in regulating the physiological function of developing sensory neurons derived from peripheral neural crest and in growth,development and maturation of satellite cells.