五种特色乳中活性蛋白及活性肽的生物活性功能研究进展

doi:10.11843/j.issn.0366-6964.2024.08.007

Abstract

Abstract:

Dairy products, as one of the essential human foods, have attracted widespread attention due to the presence of active proteins and peptides. This review summarizes the bioactive functions of active proteins and peptides in five types of specialized milk (goat, sheep, donkey, camel and yak), including their roles in regulating immune function, antioxidation, antimicrobial activity, and anti-tumor effects. Furthermore, based on relevant studies, the current review provides a prospective outlook on their potential applications in disease prevention and health promotion. This review contributes to a more comprehensive understanding of the functional mechanisms of active proteins and peptides in specialized milk, offering valuable references for future research.

Key words: specialty milk, bioactive proteins, bioactive peptides, bioactive function

CLC Number:

TS252.1

Xinke LI, Yanan GAO, Jiaqi WANG, Nan ZHENG. Research Advances in the Biological Activities of Active Proteins and Peptides in Five Specialty Milk[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(8): 3331-3343.

Figures/Tables 3

Table 1

Table 2

Fig. 1

References 98

1	MAF T,WEIJ Y,HAOL Y,et al.Bioactive proteins and their physiological functions in milk[J].Curr Protein Pept Sci,2019,20(7):759-765. doi: 10.2174/1389203720666190125104532
2	STASTNAM.Advances in separation and identification of biologically important milk proteins and peptides[J].Electrophoresis,2024,45(1-2):101-119. doi: 10.1002/elps.202300084
3	MOHANTYD P,MOHAPATRAS,MISRAS,et al.Milk derived bioactive peptides and their impact on human health-A review[J].Saudi J Biol Sci,2016,23(5):577-583. doi: 10.1016/j.sjbs.2015.06.005
4	GOBBETTIM,STEPANIAKL,DE ANGELISM,et al.Latent bioactive peptides in milk proteins: proteolytic activation and significance in dairy processing[J].Crit Rev Food Sci Nutr,2002,42(3):223-239. doi: 10.1080/10408690290825538
5	HERNÁNDEZ-LEDESMAB,DEL MAR CONTRERASM,RECIOI.Antihypertensive peptides: production, bioavailability and incorporation into foods[J].Adv Colloid Interface Sci,2011,165(1):23-35. doi: 10.1016/j.cis.2010.11.001
6	NONGONIERMAA B,FITZGERALDR J.Bioactive properties of milk proteins in humans: A review[J].Peptides,2015,73,20-34. doi: 10.1016/j.peptides.2015.08.009
7	D'AURIAE,SALVATORES,POZZIE,et al.Cow's milk allergy: immunomodulation by dietary intervention[J].Nutrients,2019,11(6):1399. doi: 10.3390/nu11061399
8	DRAGO-SERRANOM E,CAMPOS-RODRÍGUEZR,CARREROJ C,et al.Lactoferrin and peptide-derivatives: antimicrobial agents with potential use in nonspecific immunity modulation[J].Curr Pharm Design,2018,24(10):1067-1078. doi: 10.2174/1381612824666180327155929
9	BEHROUZS,SAADATS,MEMARZIAA,et al.The antioxidant, anti-inflammatory and immunomodulatory effects of camel milk[J].Front Immunol,2022,13,855342. doi: 10.3389/fimmu.2022.855342
10	BIELECKAM,CICHOSZG,CZECZOTH.Antioxidant, antimicrobial and anticarcinogenic activities of bovine milk proteins and their hydrolysates-a review[J].Int Dairy J,2022,127,105208. doi: 10.1016/j.idairyj.2021.105208
11	HERNANDEZ-CASTELLANOL E,ALMEIDAA M,CASTRON,et al.The colostrum proteome, ruminant nutrition and immunity: a review[J].Curr Protein Pept Sci,2014,15(1):64-74. doi: 10.2174/1389203715666140221124622
12	WAGNERJ,BILIADERISC G,MOSCHAKIST.Whey proteins: musings on denaturation, aggregate formation and gelation[J].Crit Rev Food Sci Nutr,2020,60(22):3793-3806. doi: 10.1080/10408398.2019.1708263
13	LAYMAND K,LÖNNERDALB,FERNSTROMJ D.Applications for α-lactalbumin in human nutrition[J].Nutr Rev,2018,76(6):444-460. doi: 10.1093/nutrit/nuy004
14	WANGC,QIAOX Y,GAOZ L,et al.Advancement on milk fat globule membrane: separation, identification, and functional properties[J].Front Nutr,2022,8,807284. doi: 10.3389/fnut.2021.807284
15	BOURLIEUC,MICHALSKIM C.Structure-function relationship of the milk fat globule[J].Curr Opin Clin Nutr Metab Care,2015,18(2):118-127. doi: 10.1097/MCO.0000000000000138
16	MANONIM,DI LORENZOC,OTTOBONIM,et al.Comparative proteomics of Milk Fat Globule Membrane (MFGM) proteome across species and lactation stages and the potentials of MFGM fractions in infant formula preparation[J].Foods,2020,9(9):1251. doi: 10.3390/foods9091251
17	SMOCZYŃSKIM,STANIEWSKIB,KIEŁCZEWSKAK.Composition and structure of the bovine milk fat globule membrane-some nutritional and technological implications[J].Food Rev Int,2012,28(2):188-202. doi: 10.1080/87559129.2011.595024
18	ALTOMONTEI,SALARIF,LICITRAR,et al.Donkey and human milk: insights into their compositional similarities[J].Int Dairy J,2019,89,111-118. doi: 10.1016/j.idairyj.2018.09.005
19	YEA Q,CUIJ,CARPENTERE,et al.Dynamic in vitro gastric digestion of infant formulae made with goat milk and cow milk: influence of protein composition[J].Int Dairy J,2019,97,76-85. doi: 10.1016/j.idairyj.2019.06.002
20	刘翠,潘健存,李媛媛,等.人乳营养成分及其生理功能[J].食品工业科技,2019,40(1):286-291.
	LIUC,PANJ C,LIY Y,et al.Nutrients and physiological functions of human milk[J].Science and Technology of Food Industry,2019,40(1):286-291.
21	CLAEYSW L,VERRAESC,CARDOENS,et al.Consumption of raw or heated milk from different species: an evaluation of the nutritional and potential health benefits[J].Food Control,2014,42,188-201. doi: 10.1016/j.foodcont.2014.01.045
22	BIADALAA,KONIECZNYP.Goat's milk-derived bioactive components-a review[J].Mljekarstvo,2018,68(4):239-253.
23	ALKAISYQ H,AL-SAADIJ S,AL-RIKABIA K J,et al.Exploring the health benefits and functional properties of goat milk proteins[J].Food Sci Nutr,2023,11(10):5641-5656. doi: 10.1002/fsn3.3531
24	VESKOUKISA S,KERASIOTIE,SKAPERDAZ,et al.Whey protein boosts the antioxidant profile of rats by enhancing the activities of crucial antioxidant enzymes in a tissue-specific manner[J].Food Chem Toxicol,2020,142,111508. doi: 10.1016/j.fct.2020.111508
25	AHMEDA S,EL-BASSIONYT,ELMALTL M,et al.Identification of potent antioxidant bioactive peptides from goat milk proteins[J].Food Res Int,2015,74,80-88. doi: 10.1016/j.foodres.2015.04.032
26	CAMPOSM I F,BARBOSAP P D S,CAMARGOL J,et al.Characterization of goat whey proteins and their bioactivity and toxicity assay[J].Food Biosci,2022,46,101591. doi: 10.1016/j.fbio.2022.101591
27	LUZC,IZZOL,RITIENIA,et al.Antifungal and antimycotoxigenic activity of hydrolyzed goat whey on Penicillium spp: an application as biopreservation agent in pita bread[J].LWT,2020,118,108717. doi: 10.1016/j.lwt.2019.108717
28	HANB S,ZHANGL N,HOUY M,et al.Phosphoproteomics reveals that camel and goat milk improve glucose homeostasis in HDF/STZ-induced diabetic rats through activation of hepatic AMPK and GSK3-GYS axis[J].Food Res Int,2022,157,111254. doi: 10.1016/j.foodres.2022.111254
29	FATCHIYAHF,ROHMAHR N,TRIPRISILAL F,et al.The caprine casein-alpha-S2 protein modulates the molecular mechanism of insulin signal transduction in type 2 diabetes rat[J].Acta Biochim Pol,2020,67(3):401-408.
30	GONGH,GAOJ,WANGY,et al.Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells[J].J Dairy Sci,2020,103(6):4907-4918. doi: 10.3168/jds.2019-17513
31	CAKIRB,TUNALI-AKBAYT.Potential anticarcinogenic effect of goat milk-derived bioactive peptides on HCT-116 human colorectal carcinoma cell line[J].Anal Biochem,2021,622,114166. doi: 10.1016/j.ab.2021.114166
32	MEDEIROSG K V V,QUEIROGAR C R E,COSTAW K A,et al.Proteomic of goat milk whey and its bacteriostatic and antitumour potential[J].Int J Biol Macromol,2018,113,116-123. doi: 10.1016/j.ijbiomac.2018.01.200
33	DE MEJIAE G,DIAV P.The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells[J].Cancer Metastasis Rev,2010,29(3):511-528. doi: 10.1007/s10555-010-9241-4
34	KALYANS,MEENAS,KAPILAS,et al.Evaluation of goat milk fat and goat milk casein fraction for anti-hypercholesterolaemic and antioxidative properties in hypercholesterolaemic rats[J].Int Dairy J,2018,84,23-27. doi: 10.1016/j.idairyj.2018.03.012
35	IBRAHIMH R,AHMEDA S,MIYATAT.Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk[J].J Adv Res,2017,8(1):63-71. doi: 10.1016/j.jare.2016.12.002
36	KERASIOTIE,STAGOSD,PRIFTISA,et al.Antioxidant effects of whey protein on muscle C2C12 cells[J].Food Chem,2014,155,271-278. doi: 10.1016/j.foodchem.2014.01.066
37	KERASIOTIE,STAGOSD,TSATSAKISA M,et al.Effects of sheep/goat whey protein dietary supplementation on the redox status of rats[J].Mol Med Rep,2018,17(4):5774-5781.
38	LÓPEZ-EXPÓSITOI,GÓMEZ-RUIZJ Á,AMIGOL,et al.Identification of antibacterial peptides from ovine αs2-casein[J].Int Dairy J,2006,16(9):1072-1080. doi: 10.1016/j.idairyj.2005.10.006
39	EL-ZAHARK M,SITOHYM,CHOISETY,et al.Antimicrobial activity of ovine whey protein and their peptic hydrolysates[J].Milchwissenschaft,2004,59(11-12):653-656.
40	VARGAS-BELLO-PÉREZE,MÁRQUEZ-HERNÁNDEZR I,HERNÁNDEZ-CASTELLANOL E.Bioactive peptides from milk: animal determinants and their implications in human health[J].J Dairy Res,2019,86(2):136-144. doi: 10.1017/S0022029919000384
41	JANF,KUMARS,JHAR.Effect of boiling on the antidiabetic property of enzyme treated sheep milk casein[J].Vet World,2016,9(10):1152-1156. doi: 10.14202/vetworld.2016.1152-1156
42	HERNÁNDEZ-LEDESMAB,RECIOI,RAMOSM,et al.Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity.Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin[J].Int Dairy J,2002,12(10):805-812. doi: 10.1016/S0958-6946(02)00080-8
43	HERNÁNDEZ-LEDESMAB,MIGUELM,AMIGOL,et al.Effect of simulated gastrointestinal digestion on the antihypertensive properties of synthetic β-lactoglobulin peptide sequences[J].J Dairy Res,2007,74(3):336-339. doi: 10.1017/S0022029907002609
44	PISANUS,PAGNOZZID,PESM,et al.Differences in the peptide profile of raw and pasteurised ovine milk cheese and implications for its bioactive potential[J].Int Dairy J,2015,42,26-33. doi: 10.1016/j.idairyj.2014.10.007
45	ASPRIM,ECONOMOUN,PAPADEMASP.Donkey milk: an overview on functionality, technology, and future prospects[J].Food Rev Int,2017,33(3):316-333. doi: 10.1080/87559129.2016.1175014
46	VINCENZETTIS,PUCCIARELLIS,POLZONETTIV,et al.Role of proteins and of some bioactive peptides on the nutritional quality of donkey milk and their impact on human health[J].Beverages,2017,3(3):34. doi: 10.3390/beverages3030034
47	尹雁玲,卢野,万祥,等.驴乳的营养成分及其保健作用的研究进展[J].食品研究与开发,2021,42(5):195-200.
	YINY L,LUY,WANX,et al.Research progress on nutrient components and health care function of donkey milk[J].Food Research and Development,2021,42(5):195-200.
48	HILLD R,NEWBURGD S.Clinical applications of bioactive milk components[J].Nutr Rev,2015,73(7):463-476. doi: 10.1093/nutrit/nuv009
49	SCHRODERK,HERTZOGP J,RAVASIT,et al.Interferon-γ: an overview of signals, mechanisms and functions[J].J Leukoc Biol,2004,75(2):163-189. doi: 10.1189/jlb.0603252
50	MAOX Y,GUJ N,SUNY,et al.Anti-proliferative and anti-tumour effect of active components in donkey milk on A549 human lung cancer cells[J].Int Dairy J,2009,19(11):703-708. doi: 10.1016/j.idairyj.2009.05.007
51	ZAVALETAN,FIGUEROAD,RⅣERAJ,et al.Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea[J].J Pediatr Gastroenterol Nutr,2007,44(2):258-264. doi: 10.1097/MPG.0b013e31802c41b7
52	BRUMINID,CRISCIONEA,BORDONAROS,et al.Whey proteins and their antimicrobial properties in donkey milk: a brief review[J].Dairy Sci Technol,2016,96(1):1-14. doi: 10.1007/s13594-015-0246-1
53	BRUMINID,FURLUNDC B,COMII,et al.Antiviral activity of donkey milk protein fractions on echovirus type 5[J].Int Dairy J,2013,28(2):109-111. doi: 10.1016/j.idairyj.2012.08.010
54	MARCONES,BELTONO,FITZGERALDD J.Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis[J].Br J Clin Pharmacol,2017,83(1):152-162. doi: 10.1111/bcp.13002
55	SIMOSY,METSIOSA,VERGINADISI,et al.Antioxidant and anti-platelet properties of milk from goat, donkey and cow: an in vitro, ex vivo and in vivo study[J].Int Dairy J,2011,21(11):901-906. doi: 10.1016/j.idairyj.2011.05.007
56	LIY,FANY M,SHAIKHA S,et al.Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes[J].J Ethnopharmacol,2020,246,112221. doi: 10.1016/j.jep.2019.112221
57	LIL,LIUX F,GUOH.The nutritional ingredients and antioxidant activity of donkey milk and donkey milk powder[J].Food Sci Biotechnol,2018,27(2):393-400.
58	CHIOZZIR Z,CAPRIOTTIA L,CAVALIEREC,et al.Purification and identification of endogenous antioxidant and ACE-inhibitory peptides from donkey milk by multidimensional liquid chromatography and nanoHPLC-high resolution mass spectrometry[J].Anal Bioanal Chem,2016,408(20):5657-5666. doi: 10.1007/s00216-016-9672-z
59	AKANE.Correction to: an evaluation of the in vitro antioxidant and antidiabetic potentials of camel and donkey milk peptides released from casein and whey proteins[J].J Food Sci Technol,2022,59(2):830. doi: 10.1007/s13197-021-05076-7
60	CIRRINCIONES,LUGANINIA,LAMBERTIC,et al.Donkey milk fermentation by Lactococcus lactis subsp. cremoris and Lactobacillus rhamnosus affects the antiviral and antibacterial milk properties[J].Molecules,2021,26(16):5100. doi: 10.3390/molecules26165100
61	ŠARIĆL Ć,ŠARIĆB M,MANDIĆA I,et al.Role of calcium content in antibacterial activity of donkeys' milk toward E. coli[J].Eur Food Res Technol,2014,239(6):1031-1039. doi: 10.1007/s00217-014-2299-4
62	COSENTINOC,LABELLAC,ELSHAFIEH S,et al.Effects of different heat treatments on lysozyme quantity and antimicrobial activity of jenny milk[J].J Dairy Sci,2016,99(7):5173-5179. doi: 10.3168/jds.2015-10702
63	TRINCHESEG,CAVALIEREG,DE FILIPPOC,et al.Human milk and donkey milk, compared to cow milk, reduce inflammatory mediators and modulate glucose and lipid metabolism, acting on mitochondrial function and oleylethanolamide levels in rat skeletal muscle[J].Front Physiol,2018,9,32. doi: 10.3389/fphys.2018.00032
64	AMATIL,MARZULLIG,MARTULLIM,et al.Donkey and goat milk intake and modulation of the human aged immune response[J].Curr Pharm Des,2010,16(7):864-869. doi: 10.2174/138161210790883651
65	JIANGL,LVJ Y,LIUJ W,et al.Donkey milk lysozyme ameliorates dextran sulfate sodium-induced colitis by improving intestinal barrier function and gut microbiota composition[J].J Funct Foods,2018,48,144-152. doi: 10.1016/j.jff.2018.07.005
66	ARABH H,SALAMAS A,ABDELGHANYT M,et al.Camel milk attenuates rheumatoid arthritis via inhibition of mitogen activated protein kinase pathway[J].Cell Physiol Biochem,2017,43(2):540-552. doi: 10.1159/000480527
67	HOMAYOUNI-TABRIZIM,ASOODEHA,SOLTANIM.Cytotoxic and antioxidant capacity of camel milk peptides: effects of isolated peptide on superoxide dismutase and catalase gene expression[J].J Food Drug Anal,2017,25(3):567-575. doi: 10.1016/j.jfda.2016.10.014
68	ESFANDIR,WALTERSM E,TSOPMOA.Antioxidant properties and potential mechanisms of hydrolyzed proteins and peptides from cereals[J].Heliyon,2019,5(4):e01538. doi: 10.1016/j.heliyon.2019.e01538
69	AHAMADS R,RAISHM,AHMADA,et al.Potential health benefits and metabolomics of camel milk by GC-MS and ICP-MS[J].Biol Trace Elem Res,2017,175(2):322-330. doi: 10.1007/s12011-016-0771-7
70	TANHAEIANA,SHAHRIARI AHMADIF,SEKHAVATIM H,et al.Expression and purification of the main component contained in camel milk and its antimicrobial activities against bacterial plant pathogens[J].Probiotics Antimicrob Proteins,2018,10(4):787-793. doi: 10.1007/s12602-018-9416-9
71	WANGR X,HANZ H,JIR M T,et al.Antibacterial activity of trypsin-hydrolyzed camel and cow whey and their fractions[J].Animals (Basel),2020,10(2):337.
72	BENKERROUMN,MEKKAOUIM,BENNANIN,et al.Antimicrobial activity of camel's milk against pathogenic strains of Escherichia coli and Listeria monocytogenes[J].Int J Dairy Technol,2004,57(1):39-43. doi: 10.1111/j.1471-0307.2004.00127.x
73	JRADZ,EL HATMIH,ADTI,et al.Antimicrobial activity of camel milk casein and its hydrolysates[J].Acta Alimentaria,2015,44(4):609-616. doi: 10.1556/066.2015.44.0034
74	AYOUBM A,PALAKKOTTA R,ASHRAFA,et al.The molecular basis of the anti-diabetic properties of camel milk[J].Diabetes Res Clin Pract,2018,146,305-312. doi: 10.1016/j.diabres.2018.11.006
75	AGRAWALR P,BUDANIAS,SHARMAP,et al.Zero prevalence of diabetes in camel milk consuming Raica community of north-west Rajasthan, India[J].Diabetes Res Clin Pract,2007,76(2):290-296. doi: 10.1016/j.diabres.2006.09.036
76	BHATD K,KANGAU,KUMARN,et al.The Raikas-a unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease[J].Hum Immunol,2014,75(12):1252-1258. doi: 10.1016/j.humimm.2014.09.009
77	KHANF B,ANWARI,REDWANE M,et al.Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways[J].J Dairy Sci,2022,105(3):1848-1861. doi: 10.3168/jds.2021-20934
78	EREIFEJK I,ALU'DATTM H,ALKHALIDYH A,et al.Comparison and characterisation of fat and protein composition for camel milk from eight Jordanian locations[J].Food Chem,2011,127(1):282-289. doi: 10.1016/j.foodchem.2010.12.112
79	MEHAIAM A,HABLASM A,ABDEL-RAHMANK M,et al.Milk composition of majaheim, wadah and Hamra camels in Saudi Arabia[J].Food Chem,1995,52(2):115-122. doi: 10.1016/0308-8146(94)P4189-M
80	BADRG,SAYEDL H,OMARH E D M,et al.Camel whey protein protects B and T cells from apoptosis by suppressing activating transcription factor-3 (ATF-3)-mediated oxidative stress and enhancing phosphorylation of AKT and IκB-α in type I diabetic mice[J].Cell Physiol Biochem,2017,41(1):41-54. doi: 10.1159/000455935
81	NONGONIERMAA B,PAOLELLAS,MUDGILP,et al.Identification of novel dipeptidyl peptidase Ⅳ (DPP-Ⅳ) inhibitory peptides in camel milk protein hydrolysates[J].Food Chem,2018,244,340-348. doi: 10.1016/j.foodchem.2017.10.033
82	KRISHNANKUTTYR,ISKANDARANIA,THERACHIYILL,et al.Anticancer activity of camel milk via induction of Autophagic death in human colorectal and breast cancer cells[J].Asian Pac J Cancer Prev,2018,19(12):3501-3509. doi: 10.31557/APJCP.2018.19.12.3501
83	EL-FAKHARANYE M,ABU-SERIEM M,LITUSE A,et al.The use of human, bovine, and camel milk albumins in anticancer complexes with oleic acid[J].Protein J,2018,37(3):203-215. doi: 10.1007/s10930-018-9770-1
84	KAMALH,JAFARS,MUDGILP,et al.Inhibitory properties of camel whey protein hydrolysates toward liver cancer cells, dipeptidyl peptidase-Ⅳ, and inflammation[J].J Dairy Sci,2018,101(10):8711-8720. doi: 10.3168/jds.2018-14586
85	YANGJ,DOUZ H,PENGX,et al.Transcriptomics and proteomics analyses of anti-cancer mechanisms of TR35-an active fraction from Xinjiang Bactrian camel milk in esophageal carcinoma cell[J].Clin Nutr,2019,38(5):2349-2359. doi: 10.1016/j.clnu.2018.10.013
86	REZAEIA,AMIRDⅣANIS,ASLA K,et al.Inhibition of the Angiotensin I Converting Enzyme (ACE) and proteolysis of non-fat probiotic yogurt[J].Braz J Food Technol,2019,22,e2018234. doi: 10.1590/1981-6723.23418
87	MOSLEHISHADM,EHSANIM R,SALAMIM,et al.The comparative assessment of ACE-inhibitory and antioxidant activities of peptide fractions obtained from fermented camel and bovine milk by Lactobacillus rhamnosus PTCC 1637[J].Int Dairy J,2013,29(2):82-87. doi: 10.1016/j.idairyj.2012.10.015
88	MUDGILP,BABYB,NGOHY Y,et al.Molecular binding mechanism and identification of novel anti-hypertensive and anti-inflammatory bioactive peptides from camel milk protein hydrolysates[J].LWT,2019,112,108193. doi: 10.1016/j.lwt.2019.05.091
89	GAMMOHS,ALU'DATTM H,TRANCHANTC C,et al.Modification of the functional and bioactive properties of camel milk casein and whey proteins by ultrasonication and fermentation with Lactobacillus delbrueckii subsp. lactis[J].LWT,2020,129,109501. doi: 10.1016/j.lwt.2020.109501
90	REDWANE R M,TABLLA.Camel lactoferrin markedly inhibits hepatitis C virus genotype 4 infection of human peripheral blood leukocytes[J].J Immunoassay Immunochem,2007,28(3):267-277. doi: 10.1080/15321810701454839
91	HABIBH M,IBRAHIMW H,SCHNEIDER-STOCKR,et al.Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities[J].Food Chem,2013,141(1):148-152. doi: 10.1016/j.foodchem.2013.03.039
92	KORISHA A.The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on the changes in incretin hormones, insulin resistance, and inflammatory cytokines[J].Horm Metab Res,2014,46(6):404-411. doi: 10.1055/s-0034-1368711
93	DRAGANIDISD,KARAGOUNISL G,ATHANAILIDISI,et al.Inflammaging and skeletal muscle: can protein intake make a difference?[J].J Nutr,2016,146(10):1940-1952. doi: 10.3945/jn.116.230912
94	MAOX Y,CHENGX,WANGX,et al.Free-radical-scavenging and anti-inflammatory effect of yak milk casein before and after enzymatic hydrolysis[J].Food Chem,2011,126(2):484-490. doi: 10.1016/j.foodchem.2010.11.025
95	YANGF Y,HEX D,CHENT,et al.Peptides isolated from yak milk residue exert antioxidant effects through Nrf2 signal pathway[J].Oxid Med Cell Longev,2021,2021,9426314. doi: 10.1155/2021/9426314
96	PEIJ J,JIANGH,LIX S,et al.Antimicrobial peptides sourced from post-butter processing waste yak milk protein hydrolysates[J].AMB Express,2017,7(1):217. doi: 10.1186/s13568-017-0497-8
97	JIX X,LIX S,MAY,et al.Differences in proteomic profiles of milk fat globule membrane in yak and cow milk[J].Food Chem,2017,221,1822-1827. doi: 10.1016/j.foodchem.2016.10.097
98	GUH F,LIANGL,ZHUZ W,et al.Preparation and identification of anti-breast cancer cells peptides released from yak milk casein[J].Front Nutr,2022,9,997514. doi: 10.3389/fnut.2022.997514

蛋白质 Protein	乳源 Milk sources
蛋白质 Protein	人乳^[21] Human milk	山羊乳^[21] Goat milk	绵羊乳^[21] Sheep milk	驴乳^[21] Donkey milk	骆驼乳^[21] Camel milk	牦牛乳^[21] Yak milk
酪蛋白 Casein	2.4~4.2	23.3~46.3	41.8~46.0	6.4~10.3	22.1~26.0	34.3~45.8
α_s1-酪蛋白 α_s1-Casein	0.8	0~13.0	15.4~22.1	0.2~1.0	5.0	9.3~13.1
α_s2-酪蛋白 α_s2-Casein	N.D	2.3~11.6	——	0.2	2.2	3.6~6.5
β-酪蛋白 β-Casein	3.9	0~29.6	15.6~17.6	3.9	12.8	15.0~20.6
κ-酪蛋白 κ-Casein	0.1	2.8~13.4	3.2~4.3	N.D	0.8	4.9~8.5
乳清蛋白 Whey protein	6.2~8.3	3.7~7.0	10.2~11.0	4.9~8.0	5.9~8.1	6.3
α-乳白蛋白 α-Lactalbumin	1.9~3.4	0.7~2.3	1~1.9	1.9	0.8~3.5	0.2~1.7
β-乳球蛋白 β-Lactoglobulin	N.D	1.5~5.0	6.5~8.5	3.3	N.D	3.4~10.1
血清白蛋白 Serum albumin	0.4~0.5	1.1	0.4~0.6	0.4	7~11.9	0.3
乳铁蛋白 Lactoferrin	1.5~2.0	0.02~0.2	0.8	0.02~7.3	0.4~3.3	0.6~1.0
免疫球蛋白 Immunoglobulin	1.0~1.3	0.2~0.5	0.7	0.7~2.2	1.5~19.6	—
溶菌酶 Lysozyme	0.1~0.9	250×10^-6	100×10^-6	1.00~1.43	680×10^-6	—
酪蛋白/乳清 Casein/whey	0.4~0.5	3.5	3.1	1.3	2.7~3.2	4.5

活性蛋白/肽 Active proteins/peptides	功能活性 Functional activity	文献 References
αs1-酪蛋白 α_s1-Casein β-酪蛋白 β-Casein	抗高血压活性抑制血管紧张素转换酶的活性和抗氧化活性	[48] [46]
溶菌酶 Lysozyme	抗炎活性抗肿瘤活性降低腹泻的发生率抗菌活性	[49] [50] [51] [52]
乳铁蛋白 Lactoferrin	抗菌活性抗肿瘤活性抑制血栓形成	[53] [48] [54]
乳过氧化物酶 Lactoperoxidase	抗氧化剂活性抗菌活性	[55] [53]
α-乳白蛋白 α-Lactalbumin	降血糖活性抗高血压活性	[56] [54]
β-乳球蛋白 β-Lactoglobulin	抗高血压活性	[54]

Research Advances in the Biological Activities of Active Proteins and Peptides in Five Specialty Milk

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 98

Related Articles 1

Recommended Articles

Metrics

Comments