反溶剂共沉淀技术制备氟苯尼考固体分散体

doi:10.11843/j.issn.0366-6964.2021.010.024

Abstract

Abstract: This article aims to prepare florfenicol amorphous solid dispersion (ASD) to improve its solubility and bioavailability. The florfenicol ASD was prepared by antisolvent coprecipitation method with hydroxypropyl methyl cellulose acetate succinate (HPMCAS-MF) as carrier. The ASD was characterized by X-ray diffraction, thermal analysis and scanning electron microscopy. The in vitro and in vivo release of florfenicol was studied by dissolution and pharmacokinetics. When the ratio of florfenicol to carrier was 5:5, a solid dispersion was formed. The results showed that there was no crystal diffraction peak of florfenicol and no specific melting point peak of florfenicol. The SEM results showed that the surface of florfenicol ASD was loose and porous, and increased the surface area, and the saturated solubility of florfenicol increased by 4.8 times, and the relative bioavailability increased by 37.2%, and no drug crystal peak appeared in the solid dispersion within 3 months. The results showed that the new solid dispersion of florfenicol prepared by co-precipitation method has good stability and could effectively improve the solubility and bioavailability of florfenicol.

Key words: florfenicol, amorphous solid dispersion, solubility, co-precipitation method

CLC Number:

LIU Lianchao, WANG Lingling, ZHANG Yuqing, LI Jinhui, ZHAO Xinghua, HE Xin. Preparation of Florfenicol Solid Dispersion by Antisolvent Co-precipitation Technology[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(10): 2934-2943.

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Preparation of Florfenicol Solid Dispersion by Antisolvent Co-precipitation Technology

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