ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2013, Vol. 44 ›› Issue (12): 1891-1899.doi: 10.11843/j.issn.0366-6964.2013.12.005

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Genome-wide Detection of Selection Signatures in Sheep Populations with Use of Population Differentiation Index FST

ZENG Tao1,2, ZHAO Fu-ping2, WANG Guang-kai2, WU Ming-ming2,3,WEI Cai-hong2, ZHANG Li2, LI Li1, ZHANG Hong-ping1*, DU Li-xin2*   

  1. (1.College of Animal Science and Technology, Sichuan Agricultural University, Ya′an 625014, China;2. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;3. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China)
  • Received:2013-07-11 Online:2013-12-23 Published:2013-12-23
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Abstract:

Based on the Illumina Ovine SNP50 Breadchip genotyping data of Sunite sheep (n=66), German Mutton sheep (n=159) and Dorper sheepn=93, population differentiation index FST was adopted to detect the selection signatures, and the genes located in selection signature regions were found by bioinformatics analyses. 343 OUTLIER SNP loci were found, harboring 365 candidate genes. Some of them were related to reproduction, meat quality and growth-related traits, such as IGF2PB3, IGF1R, BMP2, BMPR1B and CAPN3, which validated the results of our previous CNV and GWAS analyses. The result of GO analysis showed that these candidate genes enriched in the GO terms related to metabolic process and demethylation. Population differentiation index FST can be used for detecting the genes with selection signatures. These genes identified can be used as candidate genes affecting the economically important traits in sheep. This study can provide theoretical references for sheep breeding.

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