低氧适应的线粒体调控机制研究进展

doi:10.11843/j.issn.0366-6964.2013.07.001

Abstract

Abstract:

O₂ is essential to animals, and animal’s survival is threatened when cells are deprived of O₂. Eukaryotic cells respond to low-oxygen concentrations by upregulating hypoxic genes. Mitochondria have long been considered as a likely site of oxygen sensing, and mitochondrial respiratory chain is required for hypoxic signaling, though its underlying role in this process has been unclear. Mitochondria may regulate the ROS produced by respiratory chain to control the enzyme activity of PHD, or sense oxygen through the protein tyrosine nitration reaction which is the combined effect of both ROS and NO produced by mitochondria. The mtDNA mutations, cell metabolism pathway changes and respiratory chain efficiency regulations also play important roles in adaptation to hypoxia. How mitochondria play a key role in hypoxic adaptation will be reviewed, hoping more attention will be caught on the research of hypoxic adaptation and mitochondria.

CLC Number:

Q38
S813.3

ZUO Qing-qing, YAO Na, DONG Kun-zhe, YE Shao-hui, MA Yue-hui. HOW Mitochondria Play a Role in Hypoxic Adaptation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(7): 993-999.

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HOW Mitochondria Play a Role in Hypoxic Adaptation

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