芪英汤和子甘汤中药复方促进母猪繁殖性能和断奶仔猪生长性能的临床研究

doi:10.11843/j.issn.0366-6964.2022.06.032

畜牧兽医学报 ›› 2022, Vol. 53 ›› Issue (6): 1994-2004.doi: 10.11843/j.issn.0366-6964.2022.06.032

芪英汤和子甘汤中药复方促进母猪繁殖性能和断奶仔猪生长性能的临床研究

郭大伟^1,2, 侯思鲁^1,2, 池宇佳^1,2, 于非可^1,2, 尉啸涵^1,2, 邓倩^1,2, 肖传明³, 刘晓晔^1,2*, 董虹^1,2*

1. 北京农学院兽医学(中医药)北京市重点实验室，北京102206;
2. 北京农学院北京市中兽药工程技术研究中心，北京 102206;
3. 北京康华远景股份有限公司，北京 101509

收稿日期:2021-09-02 出版日期:2022-06-23 发布日期:2022-06-25
通讯作者: 刘晓晔，主要从事细菌耐药性防控和宿主导向的抗菌药物研发等研究，E-mail：xiaoyeliu@pku.edu.cn;董虹，主要从事提高机体免疫和抗菌中药筛选及分子机制研究，E-mail：donghong@bua.edu.cn
作者简介:郭大伟(1998-)，男，山东德州人，硕士生，主要从事中药复方的兽医临床研究，E-mail：GODV2023@163.com
基金资助:
北京市自然科学基金(6212005)

Clinical Research of Qiying Decoction and Zigan Decoction on Promoting Reproductive Performance of Sows and Growth Performance of Weaned Piglets

GUO Dawei^1,2, HOU Silu^1,2, CHI Yujia^1,2, YU Feike^1,2, YU Xiaohan^1,2, DENG Qian^1,2, XIAO Chuanming³, LIU Xiaoye^1,2*, DONG Hong^1,2*

1. Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China;
2. Beijing Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China;
3. Beijing Keepyoung Technology Co., Ltd., Beijing 101509, China

Received:2021-09-02 Online:2022-06-23 Published:2022-06-25

摘要/Abstract

摘要： 母猪产死胎、弱胎和断奶仔猪腹泻是兽医临床养猪业亟待解决的问题。为了响应国家在养殖业中执行的“减抗替抗”政策，本文基于中医辩证论治，探讨中草药复方芪英汤、子甘汤分别对母猪繁殖性能和断奶仔猪生长性能的影响。对同期发情的母猪(35头)和同期断奶仔猪(140头)进行中药方剂预混饲料的饲养方式，分别持续饲养至分娩结束、30 d，同时记录母猪分娩数据包括窝均出生仔猪数、窝均重、窝均死胎数、死胎率等，仔猪生长数据包括初重、末重、料肉比和腹泻率，通过酶联免疫吸附方法(ELISA)、荧光定量PCR(RT-PCR)检测母猪血清中IL-6、IL-1β、TNF-α、IgG、IgA、IgM和断奶仔猪血清中IgA的分泌情况以及母猪圆环病毒2型、伪狂犬病病毒、猪繁殖与呼吸综合征病毒及抗体来确定母猪免疫力情况。结果表明，芪英汤可以显著降低妊娠母猪炎性因子IL-6、TNF-α分泌水平，降低低胎次母猪生产新生仔猪死胎率、弱胎率、死亡率，分别下降1.96%、5.83%、8.25%，提高母猪的繁殖性能。子甘汤和芪英汤联用能够显著提高仔猪断奶后期IgA水平，降低腹泻率和料肉比, 提高生长性能，降低断奶仔猪血液中白细胞水平，红细胞恢复到正常水平。综上，中药复方芪英汤和子甘汤有助于提高母猪繁殖性能和恢复断奶仔猪生长性能。

关键词: 中药复方, 妊娠母猪繁殖性能, 断奶仔猪生长性能, 免疫力, 炎性因子

Abstract: Stillbirths, weak fetuses and diarrhea of weaned piglets in sows are urgent matters to be solved in the swine industry of veterinary clinics. In response to the national policy of "reducing resistance and replacing resistance" implemented in the breeding industry, this article discusses the effects of Chinese herbal compounds on the reproductive performance of sows and the growth performance of weaned piglets based on the dialectical treatment of traditional Chinese medicine. Feeding the sows (35 heads) and piglets (140 heads) that were in estrus during the same period were fed with pre-mixed feeds of traditional Chinese medicine, and continued to feed them until the end of farrowing and 30 days respectively. At the same time, the farrowing data of the sows including the number of piglets born in the litter were recorded. Litter average weight, number of stillbirths per litter, stillbirth rate, etc. and piglet growth data including initial weight, final weight, feed to meat ratio and diarrhea rate, detected by enzyme-linked immunosorbent assay (ELISA) and fluorescence quantitative PCR (RT-PCR) The secretion of IL-6, IL-1β, TNF-α, IgG, IgA, IgM in the serum of sows and IgA in the serum of weaned piglets, as well as sow circovirus, pseudorabies virus, pseudorabies virus, porcine reproductive and respiratory syndrome virus and their antibody to determine the immunity of sows. The results showed that Qiying Decoction can significantly reduce the secretion of inflammatory factors IL-6 and TNF-α in pregnant sows, reduce the stillbirth rate, weak birth rate and mortality rate of newborn piglets produced by low parity sows, respectively decreased by 1.96%, 5.83%, 8.25%, and improve the reproductive performance of sows. The combined use of Zigan Decoction and Qiying Decoction can significantly increase the IgA level of piglets in the late weaning period, reduce the rate of diarrhea and the ratio of feed to meat to improve growth performance, reduced white blood cell levels in the blood of weaned piglets and returned red blood cells to normal levels.In summary, the Chinese herbal compound Qiying Decoction and Zigan Decoction are helpful to improve the reproductive performance of sows and restore the growth performance of weaned piglets.

Key words: Traditional Chinese medicine compound, sow performance, growth properties of weaned piglets, immunity, inflammatory factors

中图分类号:

S853.9

郭大伟, 侯思鲁, 池宇佳, 于非可, 尉啸涵, 邓倩, 肖传明, 刘晓晔, 董虹. 芪英汤和子甘汤中药复方促进母猪繁殖性能和断奶仔猪生长性能的临床研究[J]. 畜牧兽医学报, 2022, 53(6): 1994-2004.

GUO Dawei, HOU Silu, CHI Yujia, YU Feike, YU Xiaohan, DENG Qian, XIAO Chuanming, LIU Xiaoye, DONG Hong. Clinical Research of Qiying Decoction and Zigan Decoction on Promoting Reproductive Performance of Sows and Growth Performance of Weaned Piglets[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1994-2004.

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芪英汤和子甘汤中药复方促进母猪繁殖性能和断奶仔猪生长性能的临床研究

Clinical Research of Qiying Decoction and Zigan Decoction on Promoting Reproductive Performance of Sows and Growth Performance of Weaned Piglets

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