塞内卡病毒病研究进展

doi:10.11843/j.issn.0366-6964.2017.08.002

摘要/Abstract

摘要：

塞内卡病毒病是由微RNA病毒科的A型塞内卡病毒（Senecavirus A，SVA）引起的动物传染病，主要感染猪，不同年龄阶段的猪均易感，但不同毒株的致病力明显不同，引起的临床症状也不尽相同。早期的分离株多导致亚临床感染，近年来的分离株通常引起口蹄疫样的临床症状，病猪口鼻部、蹄部出现水疱、溃疡，新生仔猪死亡率显著增加。目前，该病主要流行于加拿大、巴西和美国等国家；2015年以来，我国广东和湖北两省某些猪场相继发生SVA疫情。为提高人们对该病的认识和重视，及早做好相关防控预案和检测技术储备，笔者从病原学、流行病学、临床症状与病理变化、检疫与诊断、防控措施等方面对取得的最新研究进展进行概述。

Abstract:

Senecaviral disease is an infectious disease of animals caused by Senecavirus A (SVA), which is classified in the Picornaviridae family. SVA mainly infects pigs, and pigs of different ages are susceptible to SVA infection. However, different SVA isolates have distinct pathogenicity phenotypes for pigs, thus causing diverse clinical symptoms. Although early SVA isolates typically led to subclinical infection in pigs, those obtained in recent years usually cause clinical symptoms similar to foot-and-mouth disease. Vesicular lesions and ulcers were usually visible on the snout and/or coronary bands of SVA-infected pigs, and the neonatal mortality rate was signi-ficantly increased. At present, the disease is mainly endemic in Canada, Brazil, the United States and several other countries. However, there have been reports describing the outbreak of SVA infection in pigs in Guangdong and Hubei Province, China since 2015. In order to raise awareness and draw attention to the disease, to formulate relevant prevention and control plans, and to reserve diagnostic techniques for this disease as early as possible, the latest research progress in the aspects of etiology, epidemiology, clinical symptoms and pathologic changes, quarantine and diagnosis, prevention and control of the disease will be summarized in this review.

中图分类号:

张永宁, 吴绍强, 林祥梅. 塞内卡病毒病研究进展[J]. 畜牧兽医学报, 2017, 48(8): 1381-1388.

ZHANG Yong-ning, WU Shao-qiang, LIN Xiang-mei. The Research Progress of Senecaviral Disease[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(8): 1381-1388.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: https://www.xmsyxb.com/CN/10.11843/j.issn.0366-6964.2017.08.002

https://www.xmsyxb.com/CN/Y2017/V48/I8/1381

参考文献

[1] HALES L M, KNOWLES N J, REDDY P S, et al. Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus[J]. J Gen Virol, 2008, 89(5):1265-1275.
[2] REDDY P S, BURROUGHS K D, HALES L M, et al. Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers[J]. J Natl Cancer Inst, 2007, 99(21):1623-1633.
[3] BURKE M J. Oncolytic Seneca Valley virus:past perspectives and future directions[J]. Oncolytic Virother, 2016, 5:81-89.
[4] WADHWA L, HURWITZ M Y, CHÉVEZ-BARRIOS P, et al. Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus[J]. Cancer Res, 2007, 67(22):10653-10656.
[5] ADAMS M J, LEFKOWITZ E J, KING A M Q, et al. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2015)[J]. Arch Virol, 2015, 160(7):1837-1850.
[6] GIMENEZ-LIROLA L G, RADEMACHER C, LINHARES D, et al. Serological and molecular detection of Senecavirus A associated with an outbreak of swine idiopathic vesicular disease and neonatal mortality[J]. J Clin Microbiol, 2016, 54(8):2082-2089.
[7] BAKER K L, MOWRER C, CANON A, et al. Systematic epidemiological investigations of cases of Senecavirus A in US swine breeding herds[J]. Transbound Emerg Dis, 2017, 64(1):11-18.
[8] VANNUCCI F A, LINHARES D C L, BARCELLOS D E S N, et al. Identification and complete genome of Seneca Valley virus in vesicular fluid and sera of pigs affected with idiopathic vesicular disease, Brazil[J]. Transbound Emerg Dis, 2015, 62(6):589-593.
[9] SEGALÉS J, BARCELLOS D, ALFIERI A, et al. Senecavirus A:an emerging pathogen causing vesicular disease and mortality in pigs?[J]. Vet Pathol, 2017, 54(1):11-21.
[10] HELLEN C U T, DE BREYNE S. A distinct group of hepacivirus/pestivirus-like internal ribosomal entry sites in members of diverse Picornavirus genera:evidence for modular exchange of functional noncoding RNA elements by recombination[J]. J Virol, 2007, 81(11):5850-5863.
[11] VENKATARAMAN S, REDDY S P, LOO J, et al. Structure of Seneca Valley virus-001:an oncolytic picornavirus representing a new genus[J]. Structure, 2008, 16(10):1555-1561.
[12] GOOLIA M, VANNUCCI F, YANG M, et al. Validation of a competitive ELISA and a virus neutralization test for the detection and confirmation of antibodies to Senecavirus A in swine sera[J]. J Vet Diagn Invest, 2017, 29(2):250-253.
[13] DVORAK C M T, AKKUTAY-YOLDAR Z, STONE S R, et al. An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine[J]. BMC Vet Res, 2016, 13(1):50.
[14] BRACHT A J, O'HEARN E S, FABIAN A W, et al. Real-time reverse transcription PCR assay for detection of Senecavirus A in swine vesicular diagnostic specimens[J]. PLoS One, 2016, 11(1):e0146211.
[15] HAUSE B M, MYERS O, DUFF J, et al. Senecavirus A in pigs, United States, 2015[J]. Emerg Infect Dis, 2016, 22(7):1323-1325.
[16] CHEN Z H, YUAN F F, LI Y H, et al. Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A[J]. Virology, 2016, 497:111-124.
[17] YANG M, VAN BRUGGEN R, XU W H. Generation and diagnostic application of monoclonal antibodies against Seneca Valley virus[J]. J Vet Diagn Invest, 2012, 24(1):42-50.
[18] QIAN S H, FAN W C, QIAN P, et al. Isolation and full-genome sequencing of Seneca Valley virus in piglets from China, 2016[J]. Virol J, 2016, 13(1):173.
[19] HOLE K, AHMADPOUR F, KRISHNAN J, et al. Efficacy of accelerated hydrogen peroxide® disinfectant on foot-and-mouth disease virus, swine vesicular disease virus and Senecavirus A[J]. J Appl Microbiol, 2017, 122(3):634-639.
[20] SINGH A, MOR S K, ABOUBAKR H, et al. Efficacy of three disinfectants against Senecavirus A on five surfaces and at two temperatures[J]. J Swine Health Prod, 2017, 25(2):64-68.
[21] JOSHI L R, MOHR K A, CLEMENT T, et al. Detection of the emerging Picornavirus Senecavirus A in pigs, mice, and houseflies[J]. J Clin Microbiol, 2016, 54(6):1536-1545.
[22] MONTIEL N, BUCKLEY A, GUO B Q, et al. Vesicular disease in 9-week-old pigs experimentally infected with Senecavirus A[J]. Emerg Infect Dis, 2016, 22(7):1246-1248.
[23] CANNING P, CANON A, BATES J L, et al. Neonatal mortality, vesicular lesions and lameness associated with Senecavirus A in a U.S. sow farm[J]. Transbound Emerg Dis, 2016, 63(4):373-378.
[24] LEME R A, OLIVEIRA T E S, ALCNTARA B K, et al. Clinical manifestations of Senecavirus A infection in neonatal pigs, Brazil, 2015[J]. Emerg Infect Dis, 2016, 22(7):1238-1241.
[25] KNOWLES N J, HALES L M, JONES B H, et al. Epidemiology of Seneca Valley virus:identification and characterization of isolates from pigs in the United States[C/OL]//Northern Lights EUROPIC 2006:XIV Meeting of the European Study Group on the Molecular Biology of Picornaviruses. Saariselkä, Inari, Finland, 2006.[2017-05-24] . http://www.europic.org.uk/Europic2006/posters/Knowles.svv.01.pdf.
[26] FLACH W. Watching for seneca valley virus and killing feral hogs[Z/OL].[2017-05-24] . http://www.iowaagribusinessradionetwork.com/watching-for-seneca-valley-virus-and-killing-feral-hogs/.
[27] PASMA T, DAVIDSON S, SHAW S L. Idiopathic vesicular disease in swine in Manitoba[J]. Can Vet J, 2008, 49(1):84-85.
[28] SINGH K, CORNER S, CLARK S G, et al. Seneca Valley virus and vesicular lesions in a pig with idiopathic vesicular disease[J]. J Vet Sci Technol, 2012, 3(6):1000123.
[29] ZHANG J Q, PIEYRO P, CHEN Q, et al. Full-length genome sequences of Senecavirus A from recent idiopathic vesicular disease outbreaks in U.S. swine[J]. Genome Announc, 2015, 3(6):e01270-15.
[30] WU Q W, ZHAO X Y, CHEN Y S, et al. Complete genome sequence of Seneca Valley virus CH-01-2015 identified in China[J]. Genome Announc, 2016, 4(1):e01509-15.
[31] WU Q, ZHAO X, BAI Y, et al. The first identification and complete genome of Senecavirus A affecting pig with idiopathic vesicular disease in China[J/OL]. Transbound Emerg Dis, 2016, doi:10.1111/tbed.12557.[2017-07-07] . http://onlinelibrary.wiley.com/doi/10.1111/tbed.12557/epdf.
[32] FOWLER V L, RANSBURGH R H, POULSEN E G, et al. Development of a novel real-time RT-PCR assay to detect Seneca Valley virus-1 associated with emerging cases of vesicular disease in pigs[J]. J Virol Methods, 2017, 239:34-37.
[33] LEME R A, OLIVEIRA T E S, HEADLEY S A, et al. Pathological, immunohistochemical and molecular findings associated with Senecavirus A-induced lesions in neonatal piglets[J]. J Comp Pathol, 2016, 155(2-3):145-155.
[34] YU L T, BAXTER P A, ZHAO X M, et al. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models[J]. Neuro Oncol, 2011, 13(1):14-27.
[35] VS Guidance 7406.2.Recommendations for swine with potential vesicular disease[Z/OL]. Date 04/06/16.Veterinary Services, Animal and Plant Health Inspection Service, Marketing and Regulatory Programs, United States Department of Agriculture[2017-05-24] . https://www.aasv.org/documents/VSG7406.2_SVA_Guidelines_4516.pdf.