盐酸头孢噻呋乳房注入剂对干乳期奶牛的安全性分析

doi:doi: 10.11843/j.issn.0366-6964.2016.08.027

畜牧兽医学报 ›› 2016, Vol. 47 ›› Issue (8): 1733-1738.doi: doi: 10.11843/j.issn.0366-6964.2016.08.027

• 研究简报 • 上一篇

盐酸头孢噻呋乳房注入剂对干乳期奶牛的安全性分析

吴彤¹，赵蕾蕾²，张道康²，徐飞²，张宁³，江善祥^4* ，刘义明^2*

（1.南京农业大学生命科学院，南京 210095；2.中国农业科学院饲料研究所，北京 100081；
3.中国农业大学动物医学院，北京 100193；4.南京农业大学动物医学院，南京 210095）

收稿日期:2016-05-26 出版日期:2016-08-23 发布日期:2016-08-23
通讯作者: 江善祥，教授，E-mail：jiangshanxiang@163.com；刘义明，助理研究员，E-mail：liuyiming@caas.cn
作者简介:吴彤（1995-），女，汉族，北京市人，主要从事生物工程技术和兽药工程研究，E-mail：2715135608@qq.com，Tel:82109803
基金资助:
中国农业科学院创新工程（FRI-06）；公益性行业（农业）科研专项"新型动物专用药物的研制与应用"（201303038）

The Safety Evaluation of Ceftiofur Hydrochloride Intramammary Infusion (Dry Cow)

WU Tong ¹，ZHAO Lei-lei²，ZHANG Dao-kang ²，XU Fei²，ZHANG Ning ³，JIANG Shan-xiang^4*，LIU Yi-ming^2*

(1.College of Life Sciences，Nanjing Agricultural University，Nanjing 210095，China；
2.Feed Research Institute，Chinese Academy of Agricultural Sciences，Beijing 100081，China；
3.College of Veterinary Medicine，China Agricultural University，Beijing 100193，China；
4.College of Veterinary Medicine，Nanjing Agricultural University，Nanjing 210095，China)

Received:2016-05-26 Online:2016-08-23 Published:2016-08-23

摘要/Abstract

摘要：

为研究盐酸头孢噻呋乳房注入剂对干乳期奶牛临床使用的安全性，开展药物对健康奶牛的安全性研究，作者选择健康泌乳期奶牛12头（初产和经产各6头），四个乳区分别单次给予盐酸头孢噻呋乳房注入剂一支（规格10 mL：500 mg）。比较奶牛用药前后直肠温度、日产奶量、牛奶体细胞数和乳区病原菌的变化。整个试验期间对给药奶牛进行连续观察，记录是否出现红、肿、热、痛等临床症状。结果显示，与给药前相比，奶牛的直肠温度、日产奶量、牛奶体细胞数均无显著变化（P＞0.05），乳区病原菌数量有所减少，同时，没有增加新的病原菌。结果表明，盐酸头孢噻呋乳房注入剂对干乳期奶牛正常体温、产奶量、奶中体细胞数和乳区菌群没有不良影响，该制剂用于奶牛是安全的。

Abstract:

The aim of the study was to evaluate the safety of Ceftiofur Hydrochloride intramammary infusion (Dry Cow) for dairy cows.Twelve healthy lactating cows (include 6 primiparous cows and 6 multiparous cows) were selected for the research.There were 6 primiparous cows and 6 multiparous cows among them.All the cows had not been treated with any antibiotics by systemic or intramammary administration 30 days before.They were fed with food and water without any antibiotics and under normal conditions.All the cow’s udder regions were injected by the drug of Ceftiofur Hydrochloride intramammary infusions (Dry Cow)，and one piece of drug (specification：10 mL/500 mg) was only used for one udder region.The differences of rectal temperature，daily yielding，somatic cells number and the changes of pathogen in milk before and after administration were compared.The changes of clinical symptoms were observed all the time during the experiment.The results showed that there were no significant differences in rectal temperature，daily yielding，somatic cells number before and after administration（P＞0.05）.The number of pathogen in milk was reduced than before and there was not any new pathogen appeared at the same time.The results indicated that Ceftiofur Hydrochloride intramammary infusion (Dry Cow) have no adverse effects to dairy cows.It was safe to dairy cows when administrated according to the dosing regimen above.

中图分类号:

S859.796

吴彤，赵蕾蕾，张道康，徐飞，张宁，江善祥，刘义明. 盐酸头孢噻呋乳房注入剂对干乳期奶牛的安全性分析[J]. 畜牧兽医学报, 2016, 47(8): 1733-1738.

WU Tong，ZHAO Lei-lei，ZHANG Dao-kang，XU Fei，ZHANG Ning，JIANG Shan-xiang，LIU Yi-ming. The Safety Evaluation of Ceftiofur Hydrochloride Intramammary Infusion (Dry Cow)[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(8): 1733-1738.

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盐酸头孢噻呋乳房注入剂对干乳期奶牛的安全性分析

The Safety Evaluation of Ceftiofur Hydrochloride Intramammary Infusion (Dry Cow)

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