胞外捕获器：固有免疫细胞第三种防御机制的研究进展

doi:10.11843/j.issn.0366-6964.2016.09.004

畜牧兽医学报 ›› 2016, Vol. 47 ›› Issue (9): 1768-1774.doi: 10.11843/j.issn.0366-6964.2016.09.004

胞外捕获器：固有免疫细胞第三种防御机制的研究进展

廖成水^1，3，Boireau Pascal ²，刘明远³，程相朝^1*

（1.河南科技大学，动物疫病与公共安全重点实验室/河南省动物疫病与公共安全院士工作站，洛阳 471003；2.ANSES，Laboratory for Animal Health，Maisons-Alfort 94706；3.吉林大学，人兽共患病研究所/人兽共患病研究教育部重点实验室，长春 130062）

收稿日期:2016-04-20 出版日期:2016-09-23 发布日期:2016-09-23
通讯作者: 程相朝，教授，主要从事动物疫病分子与免疫学机制研究，E-mail：chengxch@126.com
作者简介:廖成水(1986-)，男，福建长汀人,副教授，博士，主要从事微生物感染与先天性免疫细胞作用研究，E-mail：liaochengshui33@163.com
基金资助:
国家自然科学基金重点项目（31030064）；国家自然科学基金面上项目（31572489）；河南科技大学博士启动基金项目（13480071）；河南科技大学青年科学基金资助项目（2015QN033）

Research Progress on Extracellular Traps：the Third kinds of Defence Mechanisms of Innate Immune Cells

LIAO Cheng-shui ^1，3，BOIREAU Pascal ²，LIU Ming-yuan3，CHENG Xiang-chao1*

(1.Animal Disease and Public Security Academician Workstation of Henan Province/The Key Lab of Animal Disease and Public Health，Henan University of Science and Technology，Luoyang 471003，China；2.Laboratory for Animal Health，ANSES，Maisons-Alfort 94706，France；3.Key Laboratory of Zoonisis of Ministry of Education，Institute of Zoonosis，Jilin University，Changchun 130062，China)

Received:2016-04-20 Online:2016-09-23 Published:2016-09-23

摘要/Abstract

摘要：

胞外捕获器（extracellular traps，ETs）的释放是近来新发现的一种由DNA和颗粒蛋白组成的固有免疫防御机制。作为继吞噬作用、自噬之后的第三种杀伤机制，大量的研究已经证实ETs在体内外可捕获和杀伤绝大多数的细菌、病毒、真菌和寄生虫，作者对ETs的概念、形成的分子机制以及ETs在宿主防御中的作用进行了简要的介绍，这将对固有免疫细胞防御策略的新认识具有重要的意义。

Abstract:

Extracellular traps (ETs)，composed of DNA and granular proteins，act as a sort of new innate immune phagocytosis-independent extracellular defense mechanism which was discovered in recent years.As the third killing mechanisms of innate immune cells after phagocytosis and autophagocytosis，ETs can ensnare varied kinds of invading microbes inducing bacteria，virus，fungi，and protozoa to prevent local diffusion and kill them in vitro，and also in vivo.In this review，we will briefly describe the recent progress of the concept and molecular mechanism of ETs，and its role in host defense.This review has substantial significance on the new understanding of defense strategy in innate immune cells.

中图分类号:

S852.42

廖成水，Boireau Pascal，刘明远，程相朝. 胞外捕获器：固有免疫细胞第三种防御机制的研究进展[J]. 畜牧兽医学报, 2016, 47(9): 1768-1774.

LIAO Cheng-shui，BOIREAU Pascal，LIU Ming-yuan，CHENG Xiang-chao. Research Progress on Extracellular Traps：the Third kinds of Defence Mechanisms of Innate Immune Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(9): 1768-1774.

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胞外捕获器：固有免疫细胞第三种防御机制的研究进展

Research Progress on Extracellular Traps：the Third kinds of Defence Mechanisms of Innate Immune Cells

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