畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (8): 3297-3308.doi: 10.11843/j.issn.0366-6964.2024.08.004
安塔娜(), 韩海格*(
), 陶克涛, 宝音德力格尔, 李文博, 芒来*(
)
收稿日期:
2024-01-23
出版日期:
2024-08-23
发布日期:
2024-08-28
通讯作者:
韩海格,芒来
E-mail:1665634650@qq.com;hanhaige@126.com;dmanglai@163.com
作者简介:
安塔娜(1998-),女,蒙古族,内蒙古兴安盟人,博士生,主要从事动物遗传育种与繁殖研究,E-mail:1665634650@qq.com
基金资助:
Tana AN(), Haige HAN*(
), Togtokh MONGKE, Baoyindeligeer MONGKEJARGAL, Wenbo LI, Manglai DUGARJAVIIN*(
)
Received:
2024-01-23
Online:
2024-08-23
Published:
2024-08-28
Contact:
Haige HAN, Manglai DUGARJAVIIN
E-mail:1665634650@qq.com;hanhaige@126.com;dmanglai@163.com
摘要:
家马的毛色是识别马匹和进行品种登记的主要内容及依据。古DNA研究表明,最先出现的家马毛色是骝色,在后续的演化过程中出现黑色和栗色,这3种毛色统称为基础毛色。与其他哺乳动物一样,家马的色素细胞通过真黑素和棕黑素的不同组合产生不同毛色。本文系统地总结了家马的13种不同毛色分类,综述了近三十年内关于家马不同毛色形成的候选基因研究进展,为深入解析家马不同毛色形成遗传机理、减少相关遗传疾病的发生以及后续的系谱登记和选种选育工作提供理论参考和依据。
中图分类号:
安塔娜, 韩海格, 陶克涛, 宝音德力格尔, 李文博, 芒来. 家马不同毛色遗传特性研究综述[J]. 畜牧兽医学报, 2024, 55(8): 3297-3308.
Tana AN, Haige HAN, Togtokh MONGKE, Baoyindeligeer MONGKEJARGAL, Wenbo LI, Manglai DUGARJAVIIN. A Review of the Genetic Characteristics of Different Coat Colors in Domestic Horses[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(8): 3297-3308.
1 | 韩国才. 马的起源驯化、种质资源与产业模式[J]. 生物学通报, 2014, 49 (2): 1- 3. |
HAN G C . Origin, domestication, germplasm resources and industrial model of equine[J]. Bulletin of Biology, 2014, 49 (2): 1- 3. | |
2 | 鲍红梅, 乌尼尔夫, 赵一萍, 等. 国内马匹体尺性状与生产性能相关性研究概述[J]. 黑龙江畜牧兽医, 2017, (11): 81- 83. |
BAO H M , UNILF , ZHAO Y P , et al. Overview of research on correlation between body size traits and production performance of horses in China[J]. Heilongjiang Animal Science and Veterinary Medicine, 2017, (11): 81- 83. | |
3 |
王振山, 郭永新, 李建成. 采用血液遗传标记对马亲仔关系案例的检测与分析[J]. 黑龙江畜牧兽医, 2001, (11): 4- 6.
doi: 10.3969/j.issn.1004-7034.2001.11.002 |
WANG Z S , GUO Y X , LI J C . Testing and analysis of parentage cases in horses with blood genetic markers[J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2001, (11): 4- 6.
doi: 10.3969/j.issn.1004-7034.2001.11.002 |
|
4 | 陶克涛, 韩海格, 赵若阳, 等. 家马的驯化起源与遗传演化特征[J]. 生物多样性, 2020, 28 (6): 734- 748. |
MONGKE T , HAN H G , ZHAO R Y , et al. The origins and genetic characteristics of domestic horses[J]. Biodiversity Science, 2020, 28 (6): 734- 748. | |
5 | 芒来, 杨虹. 蒙古马遗传多样性研究进展[J]. 遗传, 2008, 30 (3): 269- 276. |
DUGARJAVIIN M , YANG H . Progress in the study of genetic diversity of Mongolian horse[J]. Hereditas (Beijing), 2008, 30 (3): 269- 276. | |
6 |
LIU X X , ZHANG Y L , LI Y F , et al. EPAS1 gain-of-function Mutation contributes to high-altitude adaptation in Tibetan horses[J]. Mol Biol Evol, 2019, 36 (11): 2591- 2603.
doi: 10.1093/molbev/msz158 |
7 | 代舜尧. 甘孜藏马品种介绍[J]. 四川畜牧兽医, 2019, 46 (2): 45- 46. |
DAI S Y . Introduction of Tibetan horses in Ganzi[J]. Sichuan Animal & Veterinary Sciences, 2019, 46 (2): 45- 46. | |
8 | 孙玉江. 中国西南马遗传资源特征研究[D]. 呼和浩特: 内蒙古农业大学, 2009. |
SUN Y J. Genetic resource characters of Southwest horse populations in China[D]. Hohhot: Inner Mongolia Agricultural University, 2009. (in Chinese) | |
9 | 芒来. 新概念马学[M]. 北京: 中国农业出版社, 2015: 8. |
DUGARJAVIIN M . New concept horse science and industry[M]. Beijing: China Agriculture Press, 2015: 8. | |
10 |
LUDWIG A , PRUVOST M , REISSMANN M , et al. Coat color variation at the beginning of horse domestication[J]. Science, 2009, 324 (5926): 485.
doi: 10.1126/science.1172750 |
11 | 赵若阳, 赵一萍, 李蓓, 等. 马毛色遗传机理研究进展[J]. 遗传, 2018, 40 (5): 357- 368. |
ZHAO R Y , ZHAO Y P , LI B , et al. Overview of the genetic control of horse coat color patterns[J]. Hereditas (Beijing), 2018, 40 (5): 357- 368. | |
12 | CICHOREK M , WACHULSKA M , STASIEWICZ A , et al. Skin melanocytes: biology and development[J]. Postepy Dermatol Alergol, 2013, 30 (1): 30- 41. |
13 |
ERICKSON C A . From the crest to the periphery: control of pigment cell migration and lineage segregation[J]. Pigment Cell Res, 1993, 6 (5): 336- 347.
doi: 10.1111/j.1600-0749.1993.tb00611.x |
14 |
HUBBARD J K , UY J A C , HAUBER M E , et al. Vertebrate pigmentation: from underlying genes to adaptive function[J]. Trends Genet, 2010, 26 (5): 231- 239.
doi: 10.1016/j.tig.2010.02.002 |
15 | 张坤婷, 李小利, 李顺平. 白化病患者报告结局的系统评价[J]. 中国药物经济学, 2023, 18 (5): 18- 22. |
ZHANG K T , LI X L , LI S P . Albinism patients report outcomes: a systematic review[J]. China Journal of Pharmaceutical Economics, 2023, 18 (5): 18- 22. | |
16 | 廖景龙, 罗涵深, 霍博. 皮肤黑色素瘤预后模型的构建: 基于TCGA数据库的铁死亡相关基因[J]. 皮肤性病诊疗学杂志, 2023, 30 (4): 307- 313. |
LIAO J L , LUO H S , HUO B . Construction of a prognostic model for cutaneous melanoma based on ferroptosis related genes in the TCGA database[J]. Journal of Diagnosis and Therapy on Dermato-venereology, 2023, 30 (4): 307- 313. | |
17 |
FRANCO-BELUSSI L , DE SOUZA SANTOS L R , ZIERI R , et al. Visceral pigmentation in three species of the genus Scinax (anura: Hylidae): distinct morphological pattern[J]. Anat Rec (Hoboken), 2012, 295 (2): 298- 306.
doi: 10.1002/ar.21524 |
18 |
巫小倩, 刘辰东, 堵晶晶, 等. microRNA调控动物毛色和肤色的研究进展[J]. 畜牧兽医学报, 2016, 47 (6): 1086- 1092.
doi: 10.11843/j.issn.0366-6964.2016.06.002 |
WU X Q , LIU C D , DU J J , et al. Research progress of the role of microRNAs in the regulation of animal coat and skin color[J]. Acta Veterinaria et Zootechnica Sinica, 2016, 47 (6): 1086- 1092.
doi: 10.11843/j.issn.0366-6964.2016.06.002 |
|
19 |
MARKLUND L , MOLLER M J , SANDBERG K , et al. A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses[J]. Mamm Genome, 1996, 7 (12): 895- 899.
doi: 10.1007/s003359900264 |
20 |
RIEDER S , TAOURIT S , MARIAT D , et al. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)[J]. Mamm Genome, 2001, 12 (6): 450- 455.
doi: 10.1007/s003350020017 |
21 | NEVES A P , SCHWENGBER E B , ALBRECHT F F , et al. Beyond fifty shades: the genetics of horse colors[J]. InTech, 2017, |
22 | 尚嵩洋. MC1R和ASIP基因在马毛色中的协同作用研究及马微卫星13重PCR体系的构建[D]. 沈阳: 沈阳农业大学, 2019. |
SHANG S Y. Synergy between MC1R and ASIP for coat color in horses and development of 13-plex PCR systems for commonly used STRs in horses[D]. Shenyang: Shenyang Agricultural University, 2019. (in Chinese) | |
23 | 彭刚. 猪MC1R, ASIP, TYR, TYRP1和SLC45A2基因多态性及其与毛色相关性研究[D]. 武汉: 华中农业大学, 2019. |
PENG G. Polymorphisms of MC1R, ASIP, TYR, TYRP1 and SLC45A2 gene and their association with coat color in pigs[D]. Wuhan: Huazhong Agricultural University, 2019. (in Chinese) | |
24 |
MARIAT D , TAOURIT S , GUÉRIN G . A mutation in the MATP Gene causes the cream coat colour in the horse[J]. Genet Sel Evol, 2003, 35 (1): 119- 133.
doi: 10.1186/1297-9686-35-1-119 |
25 |
SILVA I L S , JUNQUEIRA G S B , DE ARAÚJO OLIVEIRA C A , et al. Inconsistencies in horse coat color registration: a case study[J]. J Equine Sci, 2020, 31 (3): 57- 60.
doi: 10.1294/jes.31.57 |
26 |
MASUDA M , TSUNODA J , NOMURA H , et al. New primitive marking (Bider) in Mongolian native horse and Equus przewalskii[J]. J Equine Sci, 2007, 18 (4): 145- 151.
doi: 10.1294/jes.18.145 |
27 |
IMSLAND F , MCGOWAN K , RUBIN C J , et al. Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies dun camouflage color in horses[J]. Nat Genet, 2016, 48 (2): 152- 158.
doi: 10.1038/ng.3475 |
28 |
CIESLAK J , BROOKS S A , WODAS L , et al. Genetic background of the polish primitive horse (konik) coat color variation-new insight into dun dilution phenotypic effect[J]. J Hered, 2021, 112 (5): 436- 442.
doi: 10.1093/jhered/esab034 |
29 |
STACHURSKA A M . Inheritance of primitive markings in horses[J]. J Anim Breed Genet, 1999, 116 (1): 29- 38.
doi: 10.1111/j.1439-0388.1999.00172.x |
30 |
BRUNBERG E , ANDERSSON L , COTHRAN G , et al. A missense mutation in PMEL17 is associated with the silver coat color in the horse[J]. BMC Genet, 2006, 7 (1): 46.
doi: 10.1186/1471-2156-7-46 |
31 |
HERB V M , ZEHETNER V , BLOHM K O . Multiple congenital ocular anomalies in a silver coat missouri fox trotter stallion[J]. Tierarztl Prax Ausg G Grosstiere Nutztiere, 2021, 49 (5): 350- 354.
doi: 10.1055/a-1581-4810 |
32 | ANDERSSON L S , WILBE M , VILUMA A , et al. Equine multiple congenital ocular anomalies and silver coat colour result from the pleiotropic effects of mutant PMEL[J]. PLoS One, 2013, 8 (9): e75639. |
33 | SEVANE N , SANZ C R , DUNNER S . Explicit evidence for a missense mutation in exon 4 of SLC45A2 gene causing the pearl coat dilution in horses[J]. Anim Genet, 2019, 50 (3): 275- 278. |
34 | HOLL H M , PFLUG K M , YATES K M , et al. A candidate gene approach identifies variants in SLC45A2 that explain dilute phenotypes, pearl and sunshine, in compound heterozygote horses[J]. Anim Genet, 2019, 50 (3): 271- 274. |
35 | ZANDI M B , SALEK ARDESTANI S , VAHEDI S M , et al. Detection of common copy number of variants underlying selection pressure in middle eastern horse breeds using whole-genome sequence data[J]. J Hered, 2022, 113 (4): 421- 430. |
36 | COOK D , BROOKS S , BELLONE R , et al. Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses[J]. PLoS Genet, 2008, 4 (9): e1000195. |
37 | 徐苹, 黄洁萍, 王风巧, 等. 玉树马和德保矮马SLC36A1基因多态性研究[J]. 家畜生态学报, 2013, 34 (7): 15-19, 24. |
XU P , HUANG J P , WANG F Q , et al. Polymorphisms of SLC36A1 gene in Yushu horse and Debao pony[J]. Acta Ecologiae Animalis Domastici, 2013, 34 (7): 15-19, 24. | |
38 | SPONENBERG D P , BELLONE R . Equine color genetics[M]. 4th ed Hoboken: Wiley-Blackwell, 2017. |
39 | ALEMAN M , FINNO C J , WEICH K , et al. Investigation of known genetic mutations of arabian horses in Egyptian Arabian foals with juvenile idiopathic epilepsy[J]. J Vet Intern Med, 2018, 32 (1): 465- 468. |
40 | ELA N H A , EL ARABY I E , SALEH A A , et al. Evidence for origin of lavender foal syndrome among Egyptian Arabian horses in Egypt[J]. Equine Vet J, 2023, 55 (3): 487- 493. |
41 | BROOKS S A , GABRESKI N , MILLER D , et al. Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for lavender foal syndrome[J]. PLoS Genet, 2010, 6 (4): e1000909. |
42 | BIERMAN A , GUTHRIE A J , HARPER C K . Lavender foal syndrome in Arabian horses is caused by a single-base deletion in the MYO5A gene[J]. Anim Genet, 2010, 41 (S2): 199- 201. |
43 | EDWARDS L , FINNO C J . Genetics of equine neurologic disease[J]. Vet Clin North Am Equine Pract, 2020, 36 (2): 255- 272. |
44 | SUNDSTRÖM E , IMSLAND F , MIKKO S , et al. Copy Number Expansion of the STX17 duplication in melanoma tissue from grey horses[J]. BMC Genomics, 2012, 13 (1): 365. |
45 | TEIXEIRA R B , RENDAHL A K , ANDERSON S M , et al. Coat color genotypes and risk and severity of melanoma in gray quarter horses[J]. J Vet Intern Med, 2013, 27 (5): 1201- 1208. |
46 | SELTENHAMMER M H , HEERE-RESS E , BRANDT S , et al. Comparative histopathology of grey-horse-melanoma and human malignant melanoma[J]. Pigment Cell Res, 2004, 17 (6): 674- 681. |
47 | CURIK I , DRUML T , SELTENHAMMER M , et al. Complex inheritance of melanoma and pigmentation of coat and skin in grey horses[J]. PLoS Genet, 2013, 9 (2): e1003248. |
48 | HENNER J , PONCET P A , GUÉRIN G , et al. Genetic mapping of the (G)-locus, responsible for the coat color phenotype"progressive greying with age"in horses (Equus caballus)[J]. Mamm Genome, 2002, 13 (9): 535- 537. |
49 | PIMENTA J , PRADA J , COTOVIO M . Equine melanocytic tumors: a narrative review[J]. Animals (Basel), 2023, 13 (2): 247. |
50 | 李蓓, 何小龙, 芒来. 蒙古马突触融合蛋白17(STX17)基因多态性及在不同毛色皮肤组织中的表达分析[J]. 畜牧兽医学报, 2011, 42 (11): 1632- 1637. |
LI B , HE X L , MANG L . Analysis on polymorphism and expression in different coat color skin of syntaxin-17(STX17) gene in Mongolian horse[J]. Acta Veterinaria et Zootechnica Sinica, 2011, 42 (11): 1632- 1637. | |
51 | GAO K X , CHEN N B , LIU W J , et al. Frequency of gray coat color in native Chinese horse breeds[J]. Genet Mol Res, 2015, 14 (4): 14144- 14150. |
52 | 李媛媛, 毕晓昆, 赵春江. 哺乳动物青毛色相关基因研究进展[J]. 中国畜牧杂志, 2023, 59 (9): 6- 10. |
LI Y Y , BI X K , ZHAO C J . Research progress on genes related to grey coat color of mammals[J]. Chinese Journal of Animal Science, 2023, 59 (9): 6- 10. | |
53 | BAILEY E , BROOKS S A . Horse genetics[M]. 2nd ed Oxford, UK: CABI, 2013. |
54 | VOß K , TETENS J , THALLER G , et al. Coat color roan shows association with KIT variants and no evidence of lethality in Icelandic horses[J]. Genes (Basel), 2020, 11 (6): 680. |
55 | MARKLUND S , MOLLER M , SANDBERG K , et al. Close assocation between sequence polymorphism in the KIT gene and the roan coat coulr in horses[J]. Mamm Genome, 1999, 10 (3): 283- 288. |
56 | HAASE B , BROOKS S A , TOZAKI T , et al. Seven novel KIT Mutations in horses with white coat colour phenotypes[J]. Anim Genet, 2009, 40 (5): 623- 629. |
57 | GRILZ-SEGER G , REITER S , NEUDITSCHKO M , et al. A genome-wide association analysis in Noriker horses identifies a SNP associated with roan coat color[J]. J Equine Vet Sci, 2020, 88, 102950. |
58 | VOß K , BLAJ I , TETENS J L , et al. Roan coat color in livestock[J]. Anim Genet, 2022, 53 (5): 549- 556. |
59 | BELLONE R R . Pleiotropic effects of pigmentation genes in horses[J]. Anim Genet, 2010, 41 (Suppl 2): 100- 110. |
60 | 白东义, 乌尼尔夫, 杨丽华, 等. 蒙古白马KIT基因的多态性及组织表达研究[J]. 畜牧与兽医, 2013, 45 (1): 49- 52. |
BAI D Y , UNILF , YANG L H , et al. Polymorphism and tissue expression of KIT gene in Mongolian white horse[J]. Animal Husbandry & Veterinary Medicine, 2013, 45 (1): 49- 52. | |
61 | HAASE B , BROOKS S A , SCHLUMBAUM A , et al. Allelic heterogeneity at the equine KIT locus in dominant white (W) horses[J]. PLoS Genet, 2007, 3 (11): e195. |
62 | 敖敏. 乌珠穆沁白马不同年龄段非遗传因素研究及保种调查[D]. 呼和浩特: 内蒙古农业大学, 2019. |
AO M. Investigations on non-genetic factors and conservation of different ages of Ujimchin white horse[D]. Hohhot: Inner Mongolia Agricultural University, 2019. (in Chinese) | |
63 | 白东义, 杨丽华, 乌尼尔夫, 等. Kit基因对白马被毛褪色的影响[J]. 遗传, 2011, 33 (11): 1171- 1178. |
BAI D Y , YANG L H , UNILF , et al. Effect of Kit gene on coat depigmentation in white horses[J]. Hereditas (Beijing), 2011, 33 (11): 1171- 1178. | |
64 | MAGDESIAN K G , WILLIAMS D C , ALEMAN M , et al. Evaluation of deafness in American Paint Horses by phenotype, brainstem auditory-evoked responses, and endothelin receptor B genotype[J]. J Am Vet Med Assoc, 2009, 235 (10): 1204- 1211. |
65 | MAGDESIAN K G , TANAKA J , BELLONE R R . A de novo MITF deletion explains a novel splashed white phenotype in an American Paint Horse[J]. J Hered, 2020, 111 (3): 287- 293. |
66 | HENKEL J , LAFAYETTE C , BROOKS S A , et al. Whole-genome sequencing reveals a large deletion in the MITF gene in horses with white spotted coat colour and increased risk of deafness[J]. Anim Genet, 2019, 50 (2): 172- 174. |
67 | HAUSWIRTH R , HAASE B , BLATTER M , et al. Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses[J]. PLoS Genet, 2012, 8 (4): e1002653. |
68 | NEGRO S , IMSLAND F , VALERA M , et al. Association analysis of KIT, MITF, and PAX3 Variants with white markings in Spanish horses[J]. Anim Genet, 2017, 48 (3): 349- 352. |
69 | BELLONE R R , TANAKA J , ESDAILE E , et al. A de novo 2.3 kb structural variant in MITF explains a novel splashed white phenotype in a Thoroughbred family[J]. Anim Genet, 2023, 54 (6): 752- 762. |
70 | BELLONE R R , HOLL H , SETALURI V , et al. Evidence for a Retroviral Insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse[J]. PLoS One, 2013, 8 (10): e78280. |
71 | HAASE B , JUDE R , BROOKS S A , et al. An equine chromosome 3 inversion is associated with the tobiano spotting pattern in German horse breeds[J]. Anim Genet, 2008, 39 (3): 306- 309. |
72 | BROOKS S A , LEAR T L , ADELSON D L , et al. A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses[J]. Cytogenet Genome Res, 2007, 119 (3-4): 225- 230. |
73 | BROOKS S A , BAILEY E . Exon skipping in the KIT gene causes a Sabino spotting pattern in horses[J]. Mamm Genome, 2005, 16 (11): 893- 902. |
74 | ESDAILE E , TILL B , KALLENBERG A , et al. A de novo missense mutation in KIT is responsible for dominant white spotting phenotype in a Standardbred horse[J]. Anim Genet, 2022, 53 (4): 534- 537. |
75 | HUG P , JUDE R , HENKEL J , et al. A novel KIT deletion variant in a German riding pony with white-spotting coat colour phenotype[J]. Anim Genet, 2019, 50 (6): 761- 763. |
76 | BOWLING A T . Dominant inheritance of overo spotting in paint horses[J]. Hered, 1994, 85 (3): 222- 224. |
77 | SANTSCHI E M , PURDY A K , VALBERG S J , et al. Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses[J]. Mamm Genome, 1998, 9 (4): 306- 309. |
78 | 刘琳玲, 邢秀梅, 王桂武, 等. Agouti基因的研究进展[J]. 黑龙江畜牧兽医, 2011, (8): 37- 38. |
LIU L L , XING X M , WANG G W , et al. The research progress of Agouti gene[J]. Heilongjiang Animal Science and Veterinary Medicine, 2011, (8): 37- 38. | |
79 | 章誉兴, 吴宏, 于黎. 哺乳动物毛色调控机制及其适应性进化研究进展[J]. 遗传, 2021, 43 (2): 118- 133. |
ZHANG Y X , WU H , YU L . Progress on coat color regulation mechanism and its association with the adaptive evolution in mammals[J]. Hereditas (Beijing), 2021, 43 (2): 118- 133. | |
80 | JACOBS L N , STAIGER E A , ALBRIGHT J D , et al. The MC1R and ASIP coat color loci may impact behavior in the horse[J]. J Hered, 2016, 107 (3): 214- 219. |
81 | 姜强, 孙艳, 王秀革, 等. 驴毛色主要调控基因研究进展[C]//中国畜牧业协会. 首届(2015)中国驴业发展大会高层论坛论文汇编. 聊城: 山东省农业科学院奶牛研究中心, 2015: 115-121. |
JIANG Q, SUN Y, WANG X G, et al. Progress about main regulatory genes of coat color in donkey[C]//China Animal Husbandry Association. Proceedings of the high-level forum of the first (2015) China Donkey Industry Development Conference. Liaocheng: Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, 2015: 115-121. (in Chinese) |
[1] | 肖敏, 赵威, 孙武, 娜日苏, 赵乐, 刘陶禄, 张继攀, 赵永聚. 山羊皮肤组织miRNA测序与miR-129-5p调控黑色素生成的功能研究[J]. 畜牧兽医学报, 2024, 55(3): 1019-1029. |
[2] | 唐鑫鑫, 郑炬梅, 骆娜, 营凡, 朱丹, 李森, 刘大伟, 安炳星, 文杰, 赵桂苹, 李和刚. 基于全基因组关联分析揭示肉鸡腿病发生的遗传机制[J]. 畜牧兽医学报, 2024, 55(1): 99-109. |
[3] | 梁睿, 范小瑞, 张晋强, 庞全海. 小鼠黑色素细胞沉默及过表达色素上皮衍生因子对黑色素合成的影响[J]. 畜牧兽医学报, 2023, 54(9): 3916-3930. |
[4] | 王振宇, 张赛博, 刘文慧, 梁栋, 任小丽, 闫磊, 闫跃飞, 高腾云, 张震, 黄河天. 基于SNP芯片数据分析不同奶牛场基因组近交系数及筛选功能性基因[J]. 畜牧兽医学报, 2023, 54(7): 2848-2857. |
[5] | 刘航, 王欢欢, 葛莹, 张雷, 张伟武, 魏莹晖, 李庆海, 范京辉, 章学东. 基于转录组和蛋白组筛选乌骨鸡肤色性状候选基因[J]. 畜牧兽医学报, 2023, 54(6): 2320-2329. |
[6] | 张笑科, 廖伟莉, 陈信佑, 李婷婷, 袁晓龙, 李加琪, 黄翔, 张豪. 杜洛克猪生长性状全基因组关联分析及候选基因鉴定[J]. 畜牧兽医学报, 2023, 54(5): 1868-1876. |
[7] | 陈灿灿, 蒋婧, 孙晓燕, 任航行, 李杰. AGRP基因在山羊组织表达及其对黑色素生成的作用机制[J]. 畜牧兽医学报, 2023, 54(4): 1441-1451. |
[8] | 毕欢, 覃海, 袁巍, 张雨丹, 张依裕, 陈伟. 敲降TYRP1基因对香猪表皮黑素细胞黑色素生成的影响[J]. 畜牧兽医学报, 2023, 54(10): 4143-4153. |
[9] | 张昌政, 李德森, 黄敏, 方晓敏, 赵为民, 任守文, 董焕声, 任军, 周李生. 基于全基因组填充重测序关联分析鉴别影响苏山猪初生体尺与乳头数性状的遗传位点[J]. 畜牧兽医学报, 2023, 54(1): 88-102. |
[10] | 陶伟, 侯黎明, 王彬彬, 刘航, 李开军, 尹彦镇, 郭皓, 牛培培, 张总平, 李强, 黄瑞华, 李平华. 利用全基因组选择信号方法鉴别影响猪肉滴水损失的候选基因[J]. 畜牧兽医学报, 2022, 53(5): 1373-1383. |
[11] | 路玉洁, 莫家远, 綦文晶, 朱思燃, 杨丽丽, 刘巧玲, 卜亚歌, 兰干球, 梁晶. 几个中国地方猪群体遗传结构和产仔数性状选择信号分析[J]. 畜牧兽医学报, 2022, 53(2): 360-369. |
[12] | 米布农, 张立果, 乌日汉, 郭玉林, 王春伟, 徐全忠, 冯爽, 李光鹏, 苏小虎, 张立. 戴瑞奶绵羊产奶性状的全基因组关联分析[J]. 畜牧兽医学报, 2021, 52(11): 3294-3303. |
[13] | 许冬梅, 朱芷葳, 唐中伟, 李鹏飞, 董常生, 赵宇军. miR-186-5p与α-MSH互作对绵羊黑素细胞黑色素生成的影响[J]. 畜牧兽医学报, 2021, 52(1): 19-27. |
[14] | 杨腊梅, 张婷, 张鼎. 1例肉鸡肝恶性黑色素瘤的病理学诊断[J]. 畜牧兽医学报, 2021, 52(1): 268-272. |
[15] | 吕世杰, 陈付英, 金磊, 张子敬, 朱肖亭, 施巧婷, 辛晓玲, 楚秋霞, 柏中林, 王二耀, 徐照学. 利用简化基因组测序筛选安格斯牛生长相关的受选择基因[J]. 畜牧兽医学报, 2020, 51(4): 713-721. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||