畜牧兽医学报 ›› 2013, Vol. 44 ›› Issue (10): 1509-1515.doi: 10.11843/j.issn.0366-6964.2013.10.001

• 综述 •    下一篇

长链非编码RNAs及其功能研究

朱晓攀,苗向阳*   

  1. (中国农业科学院北京畜牧兽医研究所,北京100193)
  • 收稿日期:2012-12-18 出版日期:2013-10-23 发布日期:2013-10-23
  • 通讯作者: 苗向阳,博士生导师,研究员,主要从事基因工程与功能基因组学及转基因动物的研究,E-mail:mxy32@souhu.com
  • 作者简介:朱晓攀(1987-),女,宁夏银川人,硕士生,主要从事基因工程与基因组学研究, E-mail:zxplt666@163.com
  • 基金资助:

    转基因生物新品种培育科技重大专项(2009ZX08008-004B;2008ZX08008-003);国家“863”计划项目(2008AA10Z140);国家自然科学基金项目(30571339);中国农业科学院创新基金项目(2004-院-1);中央级公益性科研院所基本科研业务费专项资金项目(2013ywf-yb-5;2013ywf-zd-2)

Long Non-coding RNAs and Its Functions

ZHU Xiao-pan, MIAO Xiang-yang*   

  1. (Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193China)
  • Received:2012-12-18 Online:2013-10-23 Published:2013-10-23

摘要:

长链非编码RNA(Long non-coding RNAs,lncRNAs)是一组长度大于200个核苷酸、缺少特异完整的开放阅读框、无蛋白质编码功能的RNA。lncRNAs可参与表观遗传修饰。许多真核生物和哺乳动物的基因组以发育调节的方式被转录,可以产生很多lncRNAs。lncRNA可通过多种途径调控DNA甲基化、组蛋白修饰、染色质重构和其他RNA干扰形式,而DNA甲基化、染色质重构等也可调控lncRNA的表达及功能,本文将对lncRNAs的功能、在基因调节中所起的作用以及在医学方面的重要性进行综述。

Abstract:

Long non-coding RNAs(lncRNAs) is a group of RNAs, which are longer than 200 nucleotides without containing functional open reading frames and cannot encode proteins. The studies indicate that lncRNAs can participate in the epigenetic modification. The most genome in mammals and other eukaryotes is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs. lncRNA can regulate DNA methylation, histone modifications, chromatin remodeling and other RNA interference through many ways, and the expression and role of lncRNA can be regulated by DNA methylation and chromatin remodeling. This article will review the lncRNAs function and its important role in gene regulation and medicine.

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