畜牧兽医学报 ›› 2010, Vol. 41 ›› Issue (7): 785-791.doi:

• 遗传繁育 •    下一篇

比值性状QTL的一种贝叶斯定位策略

孙丽华1,方铭2,高会江3*,杜红丽1   

  1. 1. 华南理工大学生物科学与工程学院, 广州 510006;2. 中国农业大学动物科学技术学院,北京 100193;3. 中国农业科学院北京畜牧兽医研究所, 北京 100193
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-20 发布日期:2010-07-20
  • 通讯作者: 高会江

A Bayesian Strategy for Mapping QTL of Ratio Traits

SUN Li-hua1, FANG Ming2, GAO Hui-jiang3*, DU Hong-li1   

  1. 1.School of Biosciences and Bioengineering, South China University of Technology,Guangzhou 510006, China; 2. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; 3. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-07-20 Published:2010-07-20

摘要: 本研究旨在对比值性状QTL采用贝叶斯定位方法进行探讨。将两个具有正态分布的普通数量性状之比定义为比值性状。 由于此类性状不服从正态分布, 因此在遗传分析上不同于普通性状。利用构成比值性状的两个组分性状的线性结合,我们提出了定位比值性状数量性状位点(QTL)的最大似然法。在此基础上,进一步探索比值性状的贝叶斯定位策略。首先采用贝叶斯压缩方法估计两个组分性状的QTL参数,然后利用两个组分性状的群体均值和QTL遗传效应,产生一个关于比值性状QTL遗传效应的后验样本,通过对这个后验样本的统计分析,来推断比值性状的QTL。模拟研究表明:新方法表现出比似然法更高的QTL检测效力。

Abstract: The research was conducted to study on the Bayesian strategy for mapping QTL of ratio traits. The ratio trait was defined as a ratio of two regular quantitative traits with normal distribution, which was distinguished from regular quantitative traits in the genetic analysis because it did not follow the normal distribution. A Bayesian mapping strategy was developed for ratio trait based on the maximum likelihood method using a special linear combination of the two component traits. The two component traits were analyzed by Bayesian shrinkage method, and then a new posterior sample of genetic effects was generated for a ratio trait from ones of population means and genetic effects for the two component traits, finally, QTL for the ratio trait was infered via post MCMC analysis for the new posterior sample. Simulations analysis demonstrated that the new method had higher detecting power for the QTL than maximum likelihood method.