猪半体内氟苯尼考对大肠杆菌的药动学-药效学同步关系研究

畜牧兽医学报 ›› 2009, Vol. 40 ›› Issue (2): 243-247.doi:

猪半体内氟苯尼考对大肠杆菌的药动学-药效学同步关系研究

杨雨辉^1，2，杨东¹，丁焕中¹，曾振灵¹*

1.华南农业大学兽医学院广东省兽药研制与安全评价重点实验室，广州 510642；2.海南大学农学院，海口 570228

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-02-24 发布日期:2009-02-24
通讯作者: 曾振灵

Pharmacokinetics/Pharmacodynamics Integration of Florfenicol against E. coli in Pigs ex vivo

YANG Yu-hui^1，2，YANG Dong¹，DING Huan-zhong¹，ZENG Zhen-ling¹*

1.Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation， College of Veterinary Medicine， South China Agricultural University， Guangzhou 510642， China;2. Hainan University of Agriculture, Haikou 570228， China

Received:1900-01-01 Revised:1900-01-01 Online:2009-02-24 Published:2009-02-24

摘要/Abstract

摘要： 采用体内药动学和体外药效学联合的方法，研究氟苯尼考在猪半体内抗大肠杆菌的活性，为合理应用氟苯尼考治疗猪大肠杆菌病提供参考。氟苯尼考在MH肉汤及血清中对猪大肠杆菌的最小抑菌浓度（MIC）分别为3.25和8.75 μg·mL^-1。猪按20 mg·kg^-1的剂量肌内注射氟苯尼考后，药物吸收缓慢且不规则，血浆药物达峰时间为（3.60±1.52）h，峰浓度为（5.28±1.48）μg·mL^-1。氟苯尼考在猪体内消除缓慢，体内平均滞留时间为（26.61±9.81）h，消除半衰期为（17.49±8.04）h。半效浓度参数（EC50）为（7.76±4.53）h。AUC0→24h/MIC为（7.69±1.48） h，Cmax/MIC为（0.60±0.17）。由于大肠杆菌对氟苯尼考的敏感性较差和氟苯尼考肌内注射药动学特征的限制，应用氟苯尼考，按照常规方案治疗猪大肠杆菌病，可能导致治疗失败。

Abstract: For the rational usage of florfenicol to treat the colibacillosis of pigs，the integration of pharmacokinetics in vivo and pharmacodynamics in vitro was used to study the antibacterial activity of florfenicol against E.coli in pig serum ex vivo. The accurate MIC of florfenicol against E. coli in MH broth and serum was 3.25 and 8.75 μg·mL^-1， respectively. Florfenicol was absorbed slowly and anomaly in pigs after intramuscular administration（20 mg·kg^-1）. The Cmax was (5.28±1.48) μg·mL^-1 at (3.60±1.52) h. The elimination of florfenicol was slow in pigs. Mean residence time(MRT) was (26.61±9.81) h. Elimination halflife(t1/2β) was (17.49±8.04) h. EC50 was (7.76±4.53) h. AUC0→24/MIC was (7.69±1.48) h and Cmax/MIC was (0.60±0.17). Because of the poor activity of florfenicol against E.coli and the lower plasma Cmax of florfenicol in pigs， it may fail to get desirable treatment result when curing the infection of E. coli in pigs by the routine regimen.

杨雨辉;杨东;丁焕中;曾振灵. 猪半体内氟苯尼考对大肠杆菌的药动学-药效学同步关系研究[J]. 畜牧兽医学报, 2009, 40(2): 243-247.

YANG Yu-hui;YANG Dong;DING Huan-zhong;ZENG Zhen-ling. Pharmacokinetics/Pharmacodynamics Integration of Florfenicol against E. coli in Pigs ex vivo[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2009, 40(2): 243-247.

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