恒定链的多功能研究新进展

doi:10.11843/j.issn.0366-6964.2023.05.006

摘要/Abstract

摘要： 恒定链(invariant chain,Ii)是重要的免疫分子。研究发现Ii不仅是MHCII类分子的伴侣分子,而且具有多种功能。本文首先概述了Ii的基本结构、主要功能、胞内组装和转运、Ii作为载体的应用。其次,归纳和总结了近几年关于Ii的最新研究进展:Ii与MHC分子互相作用的功能结构域及其在细胞的定位特征、调节T和B等免疫细胞的功能与途径、Ii与巨噬细胞迁移因子相互作用从而启动炎症反应的信号通路和相应结构域;与Ii关联的多种酶类和生物活性因子及其作用特点、与Ii相关的疾病;基于Ii结构的疫苗载体及其增强免疫的机理;以及我国在畜禽、鱼类上的研究成果。最后,展望了Ii在理论研究和畜牧兽医领域实际应用的发展趋势。本文从宏观和微观方面进行阐述,了解、认识Ii在动物免疫中的多功能作用及其机理的科学知识和最新进展,为推动相关研究提供有益借鉴和参考。

关键词: 恒定链, 多功能, 免疫调节, 疫苗载体

Abstract: Invariant chain (Ii) is an important immune molecule. It is found that Ii is not only a MHCII chaperone, but also has multiple functions. In this paper, the basic structure, main functions, intracellular assembly and transport of Ii and the applications of Ii as a carrier are summarized. Secondly, it reviews the new progress of Ii research in recent years:the functional domain of interaction between Ii and MHC molecular and their intracellular localization characteristic, the function and pathway of regulating immune cells such as T and B, Ii and macrophage migration inhibitory factor to initiate signaling pathways and corresponding domains of inflammatory response; Various enzymes and bioactive factors associated with Ii and their action characteristics, diseases associated with Ii; Vaccine vector based on Ii structure and its mechanism of enhancing immunity; And the research results on livestock, poultry and fish. Finally, the development trend of Ii in the theoretical research and practical application in the field of animal husbandry and veterinary is prospected. This review provides scientific knowledge and the latest progress in understanding the multifunctional role and mechanism of Ii in animal immunity from the macro and micro aspects, and provides useful reference for promoting related research.

Key words: invariant chain, multi-function, immune regulation, vaccine carrier

中图分类号:

S852.4

陈芳芳, 栗中华, 朱志伟, 李锦春, 刘翠艳. 恒定链的多功能研究新进展[J]. 畜牧兽医学报, 2023, 54(5): 1824-1833.

CHEN Fangfang, LI Zhonghua, ZHU Zhiwei, LI Jinchun, LIU Cuiyan. Recent Advances in Multifunctional Research of Invariant Chain[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1824-1833.

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