畜牧兽医学报 ›› 2023, Vol. 54 ›› Issue (3): 889-899.doi: 10.11843/j.issn.0366-6964.2023.03.004
姜慧华1, 李宁1, 徐磊2, 郭抗抗1*
收稿日期:
2022-03-07
出版日期:
2023-03-23
发布日期:
2023-03-21
通讯作者:
郭抗抗,主要从事分子病原学与免疫学研究,E-mail:guokk2007@nwsuaf.edu.cn
作者简介:
姜慧华(1997-),女,壮族,广西贵港人,硕士生,主要从事分子病原学与免疫学研究,E-mail:3462350283@qq.com
基金资助:
JIANG Huihua1, LI Ning1, XU Lei2, GUO Kangkang1*
Received:
2022-03-07
Online:
2023-03-23
Published:
2023-03-21
摘要: 中性粒细胞约占哺乳动物白细胞总数的50%~70%,是机体应对病原体入侵的第一道防线之一。中性粒细胞在动物机体先天免疫应答中发挥重要作用,通过吞噬、脱颗粒、形成胞外诱捕网等方式抑制或清除多种侵入的病原体。中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是中性粒细胞受包括病原体在内的激活剂刺激后向胞外分泌的由DNA、颗粒蛋白和组蛋白等构成的纤维网状结构。最初,研究者们发现NETs在抗细菌感染中发挥重要作用,可将细菌局限在感染部位,抑制或杀死细菌。随着研究的逐渐深入和发展,发现NETs除了在细菌感染方面发挥抗菌作用外,在真菌、寄生虫和病毒的感染过程中也有重要的抵御作用。但是,病原体会进化出各种逃避策略,抑制NETs的抗性。甚至有些病原体还利用NETs促进感染,导致病患难以恢复健康。本文重点对病原感染过程中NETs的形成、诱导因素和作用等进行论述,以期为病原感染机制的研究提供新的思路,也为各种病原体感染的防控提供新的途径。
中图分类号:
姜慧华, 李宁, 徐磊, 郭抗抗. 中性粒细胞胞外诱捕网在病原感染中的作用研究进展[J]. 畜牧兽医学报, 2023, 54(3): 889-899.
JIANG Huihua, LI Ning, XU Lei, GUO Kangkang. Research Progress on the Role of Neutrophil Extracellular Traps in Pathogenic Infection[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 889-899.
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