畜牧兽医学报 ›› 2022, Vol. 53 ›› Issue (12): 4159-4171.doi: 10.11843/j.issn.0366-6964.2022.12.004
王吉1,2,3, 刘翔燕1, 李晓文1, 李荣芳1, 文利新1,4*
收稿日期:
2022-01-06
出版日期:
2022-12-23
发布日期:
2022-12-25
通讯作者:
文利新,主要从事兽医内科学、营养代谢与动物保健研究,E-mail:sfwlx8015@sina.com
作者简介:
王吉(1990-),男,湖南邵阳人,博士,主要从事兽医内科学、营养代谢与动物保健研究,E-mail:wangjics@163.com;刘翔燕(1996-),女,湖南娄底人,硕士,主要从事营养代谢与动物保健研究,E-mail:liuxiangyan@stu.hunau.edu.cn。王吉和刘翔燕为同等贡献作者
基金资助:
WANG Ji1,2,3, LIU Xiangyan1, LI Xiaowen1, LI Rongfang1, WEN Lixin1,4*
Received:
2022-01-06
Online:
2022-12-23
Published:
2022-12-25
摘要: 母羊的生殖应激主要包括母羊主动应激、母羊被动应激以及胎羊宫内应激。适当的生殖应激是正常发情、维持妊娠、发动分娩、顺利哺乳的重要生理基础。但长期或过度的生殖应激,将引起母羊代谢紊乱、免疫功能损害、生殖障碍以及胎羊或羔羊发育受阻等,这一系列能造成母体健康损害的疾病和临床表现,被定义为“母羊生殖应激综合征”。本文对母羊生殖应激及母羊生殖应激综合征进行了定义,并对生殖应激理论的综合临床应用进行了探讨,为预防和治疗生殖疾病(如妊娠期毒血症、产后乏力、子宫内膜炎等)提供了理论依据。
中图分类号:
王吉, 刘翔燕, 李晓文, 李荣芳, 文利新. 新疾病:母羊生殖应激及其综合征[J]. 畜牧兽医学报, 2022, 53(12): 4159-4171.
WANG Ji, LIU Xiangyan, LI Xiaowen, LI Rongfang, WEN Lixin. New Disease: Ewe’s Reproductive Stress and Its Syndrome[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(12): 4159-4171.
[1] | 文利新, 袁 慧, 蒋政云, 等. 135保健养猪技术及应用[C]//2003全国家畜内科学学术研讨会论文专辑. 长沙:《湖南农业大学学报》编辑委员会, 2003:166-168.WEN L X, YUAN H, JIANG Z Y, et al. 135 Health care pig raising technology and application[C]//Paper album of the 2003 National Symposium on Domestic Animal Medicine. Changsha:Editorial Committee of Journal of Hunan Agricultural University, 2003:166-168. (in Chinese) |
[2] | WEN L X, LI R F, WANG J, et al. The reproductive stress hypothesis[J]. Reproduction, 2019, 158(6):R209-R218. |
[3] | 文利新, 袁 慧, 谢 岚. 母猪生殖应激及其综合征[J]. 中国兽医杂志, 2009, 45(1):56-57.WEN L X, YUAN H, XIE L. Reproductive stress and its syndrome in sows[J]. Chinese Journal of Veterinary Medicine, 2009, 45(1):56-57.(in Chinese) |
[4] | 文利新, 袁 慧, 易金娥. 奶牛生殖应激综合征及其防治原则[J]. 中国奶牛, 2008(3):28-30.WEN L X, YUAN H, YI J E. Reproducing stress syndrome in cows and its principle of prevention and treatment[J]. China Cows, 2008(3):28-30. (in Chinese) |
[5] | LINGIS M, RICHARDS E, PERRONE D, et al. Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy[J]. Am J Physiol Endocrinol Metab, 2012, 302(10):E1231-E1238. |
[6] | KELLER-WOOD M, WOOD C E. Regulation of maternal ACTH in ovine pregnancy:does progesterone play a role?[J]. Am J Physiol Endocrinol Metab, 2008, 295(4):E913-E920. |
[7] | HYDBRING E, MADEJ A, MACDONALD E, et al. Hormonal changes during parturition in heifers and goats are related to the phases and severity of labour[J]. J Endocrinol, 1999, 160(1):75-85. |
[8] | KELLER-WOOD M. Evidence for reset of regulated cortisol in pregnancy:studies in adrenalectomized ewes[J]. Am J Physiol, 1998, 274(1):R145-R151. |
[9] | KELLER-WOOD M, WOOD C E. Pregnancy alters cortisol feedback inhibition of stimulated ACTH:studies in adrenalectomized ewes[J]. Am J Physiol Regul Integr Comp Physiol, 2001, 280(6):R1790-R1798. |
[10] | LINGIS M, RICHARDS E M, KELLER-WOOD M. Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes[J]. Am J Physiol Endocrinol Metab, 2011, 300(3):E592-E599. |
[11] | ANTOLIC A, WOOD C E, KELLER-WOOD M. Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth[J]. Am J Physiol Regul Integr Comp Physiol, 2018, 314(3):R342-R352. |
[12] | VAUGHAN O R, DAVIES K L, WARD J W, et al. A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe[J]. J Physiol, 2016, 594(21):6407-6418. |
[13] | YOUNG S F, ROSE J C. Attenuation of corticotropin-releasing hormone and arginine vasopressin responsiveness during late-gestation pregnancy in sheep[J]. Biol Reprod, 2002, 66(6):1805-1812. |
[14] | HASIEC M, TOMASZEWSKA-ZAREMBA D, MISZTAL T. Suckling and salsolinol attenuate responsiveness of the hypothalamic-pituitary-adrenal axis to stress:focus on catecholamines, corticotrophin-releasing hormone, adrenocorticotrophic hormone, cortisol and prolactin secretion in lactating sheep[J]. J Neuroendocrinol, 2014, 26(12):844-852. |
[15] | HASIEC M, HERMAN A P, MISZTAL T. Salsolinol:a potential modulator of the activity of the hypothalamic-pituitary-adrenal axis in nursing and postweaning sheep[J]. Domest Anim Endocrinol, 2015, 53:26-34. |
[16] | COULTER C L, ROSS J T, OWENS J A, et al. Role of pituitary POMC-peptides and insulin-like growth factor II in the developmental biology of the adrenal gland[J]. Arch Physiol Biochem, 2002, 110(1-2):99-105. |
[17] | RÉPÉRANT E N, DURAND P. The development of the ovine fetal adrenal gland and its regulation[J]. Reprod Nutr Dev, 1997, 37(1):81-95. |
[18] | COTTRELL E C, SECKL J R. Prenatal stress, glucocorticoids and the programming of adult disease[J]. Front Behav Neurosci, 2009, 3:19. |
[19] | CHALLIS J R G, BROOKS A N. Maturation and activation of hypothalamic-pituitary adrenal function in fetal sheep[J]. Endocr Rev, 1989, 10(2):182-204. |
[20] | MYERS D A, MYERS T R, GROBER M S, et al. Levels of corticotropin-releasing hormone messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus and proopiomelanocortin mRNA in the anterior pituitary during late gestation in fetal sheep[J]. Endocrinology, 1993, 132(5):2109-2116. |
[21] | MASTORAKOS G, ILIAS I. Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum[J]. Ann N Y Acad Sci, 2003, 997(1):136-149. |
[22] | SPERLING M A, GANGULI S, LESLIE N, et al. Fetal-perinatal catecholamine secretion:role in perinatal glucose homeostasis[J]. Am J Physiol, 1984, 247(1):E69-E74. |
[23] | MATTHEWS S G, CHALLIS J R G. Regulation of the hypothalamo-pituitary-adrenocortical axis in fetal sheep[J]. Trends Endocrinol Metab, 1996, 7(7):239-246. |
[24] | CHALLIS J R G, MATTHEWS S G, GIBB W, et al. Endocrine and paracrine regulation of birth at term and preterm[J]. Endocr Rev, 2000, 21(5):514-550. |
[25] | WOOD C E. Estrogen/hypothalamus-pituitary-adrenal axis interactions in the fetus:The interplay between placenta and fetal brain[J]. J Soc Gynecol Invest, 2005, 12(2):67-76. |
[26] | CHALLIS J R, SLOBODA D, MATTHEWS S G, et al. The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health[J]. Mol Cell Endocrinol, 2001, 185(1-2):135-144. |
[27] | ANTOLOVICH G C, MCMILLEN I C, ROBINSON P M, et al. The effect of hypothalamo-pituitary disconnection on the functional and morphologic development of the pituitary-adrenal axis in the fetal sheep in the last third of gestation[J]. Neuroendocrinology, 1991, 54(3):254-261. |
[28] | GOLAND R S, WARDLAW S L, BLUM M, et al. Biologically active corticotropin-releasing hormone in maternal and fetal plasma during pregnancy[J]. Am J Obstetr Gynecol, 1988, 159(4):884-890. |
[29] | LAATIKAINEN T, VIRTANEN T, RÄISÄNEN I, et al. Immunoreactive corticotropin-releasing factor and corticotropin during pregnancy, labor and puerperium[J]. Neuropeptides, 1987, 10(4):343-353. |
[30] | JESKE W, SOSZYŃSKI P, LUKASZEWICZ E, et al. Enhancement of plasma corticotropin-releasing hormone in pregnancy-induced hypertension[J]. Eur J Endocrinol, 1990, 122(6):711-714. |
[31] | GILL R D, HART I C. Hepatic receptors for insulin and glucagon in relation to plasma hormones and metabolites in pregnant and unmated ewes[J]. J Endocrinol, 1982, 93(2):231-238. |
[32] | GILL R D, HART I C. Properties of insulin and glucagon receptors on sheep hepatocytes:a comparison of hormone binding and plasma hormones and metabolites in lactating and non-lactating ewes[J]. J Endocrinol, 1980, 84(2):237-247. |
[33] | CHADIO S E, KOTSAMPASI B, PAPADOMICHELAKIS G, et al. Impact of maternal undernutrition on the hypothalamic-pituitary-adrenal axis responsiveness in sheep at different ages postnatal[J]. J Endocrinol, 2007, 192(3):495-503. |
[34] | VONNAHME K A, NEVILLE T L, PERRY G A, et al. Maternal dietary intake alters organ mass and endocrine and metabolic profiles in pregnant ewe lambs[J]. Anim Reprod Sci, 2013, 141(3-4):131-141. |
[35] | DUEHLMEIER R, FLUEGGE I, SCHWERT B, et al. Insulin sensitivity during late gestation in ewes affected by pregnancy toxemia and in ewes with high and low susceptibility to this disorder[J]. J Vet Int Med, 2013, 27(2):359-366. |
[36] | DUEHLMEIER R, NOLDT S, GANTER M. Pancreatic insulin release and peripheral insulin sensitivity in German black headed mutton and Finish Landrace ewes:evaluation of the role of insulin resistance in the susceptibility to ovine pregnancy toxemia[J]. Domest Anim Endocrinol, 2013, 44(4):213-221. |
[37] | DUEHLMEIER R, FLUEGGE I, SCHWERT B, et al. Post-glucose load changes of plasma key metabolite and insulin concentrations during pregnancy and lactation in ewes with different susceptibility to pregnancy toxaemia[J]. J Anim Physiol Anim Nutr, 2013, 97(5):971-985. |
[38] | KANETA M, LIECHTY E A, MOOREHEAD H C, et al. Ovine fetal and maternal glycogen during fasting[J]. Biol Neonate, 1991, 60(3-4):215-220. |
[39] | MOALLEM U, ROZOV A, GOOTWINE E, et al. Plasma concentrations of key metabolites and insulin in late-pregnant ewes carrying 1 to 5 fetuses[J]. J Anim Sci, 2012, 90(1):318-324. |
[40] | HU F, XUE Y F, GUO C Z, et al. The response of ruminal fermentation, epithelium-associated microbiota, and epithelial barrier function to severe feed restriction in pregnant ewes[J]. J Anim Sci, 2018, 96(10):4293-4305. |
[41] | XUE Y F, GUO C Z, HU F, et al. Hepatic metabolic profile reveals the adaptive mechanisms of ewes to severe undernutrition during late gestation[J]. Metabolites, 2018, 8(4):85. |
[42] | SCHLUMBOHM C, HARMEYER J. Hyperketonemia impairs glucose metabolism in pregnant and nonpregnant ewes[J]. J Dairy Sci, 2004, 87(2):350-358. |
[43] | HOU L, HELLGREN L I, KONGSTED A H, et al. Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep[J]. Acta Physiol, 2014, 210(2):317-329. |
[44] | HARMEYER J, SCHLUMBOHM C. Pregnancy impairs ketone body disposal in late gestating ewes:implications for onset of pregnancy toxaemia[J]. Res Vet Sci, 2006, 81(2):254-264. |
[45] | HEFNAWY A E, YOUSSEF S, SHOUSHA S. Some immunohormonal changes in experimentally pregnant toxemic goats[J]. Vet Med Int, 2010, 2010:768438. |
[46] | YAMEOGO N, OUEDRAOGO G A, KANYANDEKWE C, et al. Relationship between ketosis and dairy cows’ blood metabolites in intensive production farms of the periurban area of Dakar[J]. Trop Anim Health Prod, 2008, 40(7):483-490. |
[47] | LOTFOLLAHZADEH S, ZAKIAN A, TEHRANI-SHARIF M, et al. Assessment the alterations of some biochemical parameters in Afshari sheep with possible metabolic disorders[J]. Small Rumin Res, 2016, 145:58-64. |
[48] | BROZOS C, MAVROGIANNI V S, FTHENAKIS G C. Treatment and control of peri-parturient metabolic diseases:pregnancy toxemia, hypocalcemia, hypomagnesemia[J]. Vet Clin North Am Food Anim Pract, 2011, 27(1):105-113. |
[49] | VASAVA P R, JANI R G, GOSWAMI H V, et al. Studies on clinical signs and biochemical alteration in pregnancy toxemic goats[J]. Vet World, 2016, 9(8):869-874. |
[50] | DHAOUI A, CHNITER M, ATIGUI M, et al. Factors affecting the milk yield and composition over lactation of prolific D’man ewes in Tunisian oases[J]. Trop Anim Health Prod, 2019, 51(3):507-518. |
[51] | SCHLUMBOHM C, HARMEYER J. Twin-pregnancy increases susceptibility of ewes to hypoglycaemic stress and pregnancy toxaemia[J]. Res Vet Sci, 2008, 84(2):286-299. |
[52] | BOLLO E, BASSANO B, PERACINO V, et al. Effect of emanciation on liver histology of alpine chamois during winter[J]. J Wildlife Dis, 1999, 35(4):770-773. |
[53] | RATANAPOB N, VANLEEUWEN J, MCKENNA S, et al. The association of serum β-hydroxybutyrate concentration with fetal number and health indicators in late-gestation ewes in commercial meat flocks in Prince Edward Island[J]. Prev Vet Med, 2018, 154:18-22. |
[54] | DOWNS C J, BOAN B V, LOHUIS T D, et al. Investigating relationships between reproduction, immune defenses, and cortisol in dall sheep[J]. Front Immunol, 2018, 9:105. |
[55] | MINTON J E. Function of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in models of acute stress in domestic farm animals[J]. J Anim Sci, 1994, 72(7):1891-1898. |
[56] | SAPOLSKY R M, ROMERO L M, MUNCK A U. How do glucocorticoids influence stress responses?Integrating permissive, suppressive, stimulatory, and preparative actions[J]. Endocr Rev, 2000, 21(1):55-89. |
[57] | STERNBERG E M. Neural regulation of innate immunity:a coordinated nonspecific host response to pathogens[J]. Nat Rev Immunol, 2006, 6(4):318-328. |
[58] | MARTIN L B. Stress and immunity in wild vertebrates:timing is everything[J]. General Comparat Endocrinol, 2009, 163(1-2):70-76. |
[59] | ROBINSON D P, KLEIN S L. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis[J]. Horm Behav, 2012, 62(3):263-271. |
[60] | CAROPRESE M, CILIBERTI M G, ALBENZIO M, et al. Dietary polyunsaturated fatty acids from flaxseed affect immune responses of dairy sheep around parturition[J]. Vet Immunol Immunopathol, 2015, 168(1-2):56-60. |
[61] | WALSH S W, WILLIAMS E J, EVANS A C O. A review of the causes of poor fertility in high milk producing dairy cows[J]. Anim Reprod Sci, 2011, 123(3-4):127-138. |
[62] | ROCHE J F. The effect of nutritional management of the dairy cow on reproductive efficiency[J]. Anim Reprod Sci, 2006, 96(3-4):282-296. |
[63] | KIYMA Z, ALEXANDER B M, VAN KIRK E A, et al. Effects of feed restriction on reproductive and metabolic hormones in ewes[J]. J Anim Sci, 2004, 82(9):2548-2557. |
[64] | CIECHANOWSKA M, ŁAPOT M, MALEWSKI T, et al. Effects of corticotropin-releasing hormone and its antagonist on the gene expression of gonadotrophin-releasing hormone (GnRH) and GnRH receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes[J]. Reprod Fertil Dev, 2011, 23(6):780-787. |
[65] | BASSETT J M, HANSON C. Prevention of hypoinsulinemia modifies catecholamine effects in fetal sheep[J]. Am J Physiol Regulat Integrat Comparat Physiol, 2000, 278(5):R1171-R1181. |
[66] | DAVIS M A, CAMACHO L E, ANDERSON M J, et al. Chronically elevated norepinephrine concentrations lower glucose uptake in fetal sheep[J]. Am J Physiol Regul Integr Comp Physiol, 2020, 319(3):R255-R263. |
[67] | LIMESAND S W, ROZANCE P J. Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency[J]. J Physiol, 2017, 595(15):5103-5113. |
[68] | RAKERS F, FRAUENDORF V, RUPPRECHT S, et al. Effects of early- and late-gestational maternal stress and synthetic glucocorticoid on development of the fetal hypothalamus-pituitary-adrenal axis in sheep[J]. Stress, 2013, 16(1):122-129. |
[69] | WALEJKO J M, ANTOLIC A, KOELMEL J P, et al. Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart[J]. Am J Physiol Endocrinol Metabo, 2019, 316(3):E546-E556. |
[70] | OSGERBY J C, WATHES D C, HOWARD D, et al. The effect of maternal undernutrition on ovine fetal growth[J]. J Endocrinol, 2002, 173(1):131-141. |
[71] | LIU Y C, HE S, ZHANG Y, et al. Effects of intrauterine growth restriction during late pregnancy on the development of the ovine fetal thymus and the T-lymphocyte subpopulation[J]. Am J Reprod Immunol, 2015, 74(1):26-37. |
[72] | ZHANG H, ZHAO F F, NIE H T, et al. Dietary N-carbamylglutamate and rumen-protected L-arginine supplementation during intrauterine growth restriction in undernourished ewes improve fetal thymus development and immune function[J]. Reprod Fertil Dev, 2018, 30(11):1522-1531. |
[73] | CHADIO S, KATSAFADOU A, KOTSAMPASI B, et al. Effects of maternal undernutrition during late gestation and/or lactation on colostrum synthesis and immunological parameters in the offspring[J]. Reprod Fertil Dev, 2016, 28(3):384-393. |
[74] | KERSLAKE J, KENYON P, MORRIS S, et al. Does offering concentrate supplement during late pregnancy affect twin- and triplet-bearing ewe and lamb performance?[J]. New Zeal J Agric Res, 2010, 53(3):315-325. |
[75] | SORMUNEN-CRISTIAN R, JAUHIAINEN L. Comparison of hay and silage for pregnant and lactating Finnish Landrace ewes[J]. Small Rumin Res, 2001, 39(1):47-57. |
[76] | VESHKINI A, MOHAMMADI-SANGCHESHMEH A, ALAMOUTI A A, et al. Maternal supplementation with fish oil modulates inflammation-related MicroRNAs and genes in suckling lambs[J]. Trop Anim Health Prod, 2020, 52(4):1561-1572. |
[77] | NICKLES K R, HAMER L, COLEMAN D N, et al. Supplementation with eicosapentaenoic and docosahexaenoic acids in late gestation in ewes changes adipose tissue gene expression in the ewe and growth and plasma concentration of ghrelin in the offspring[J]. J Anim Sci, 2019, 97(6):2631-2643. |
[78] | ZHANG H, SUN L W, WANG Z Y, et al. Dietary N-carbamylglutamate and rumen-protected L-arginine supplementation ameliorate fetal growth restriction in undernourished ewes[J]. J Anim Sci, 2016, 94(5):2072-2085. |
[79] | CELI P. The role of oxidative stress in small ruminants’ health and production[J]. Rev Bras Zootecn, 2010, 39(S1):348-363. |
[80] | CARCANGIU V, VACCA G M, PARMEGGIANI A, et al. The effect of shearing procedures on blood levels of growth hormone, cortisol and other stress haematochemical parameters in Sarda sheep[J]. Animal, 2008, 2(4):606-612. |
[81] | CHANDLER K D, LEURY B J, BIRD A R, et al. Effects of undernutrition and exercise during late pregnancy on uterine, fetal and uteroplacental metabolism in the ewe[J]. Br J Nutr, 1985, 53(3):625-635. |
[82] | LEURY B J, BIRD A R, CHANDLER K D, et al. Glucose partitioning in the pregnant ewe:effects of undernutrition and exercise[J]. Br J Nutr, 1990, 64(2):449-462. |
[83] | TILBROOK A J, TURNER A I, IBBOTT M D, et al. Activation of the hypothalamo-pituitary-adrenal axis by isolation and restraint stress during lactation in ewes:effect of the presence of the lamb and suckling[J]. Endocrinology, 2006, 147(7):3501-3509. |
[84] | DOBSON H, ROUTLY J E, SMITH R F. Understanding the trade-off between the environment and fertility in cows and ewes[J]. Anim Reprod, 2020, 17(3):e20200017. |
[85] | SILVA P S, HOOPER H B, MANICA E, et al. Heat stress affects the expression of key genes in the placenta, placental characteristics, and efficiency of Saanen goats and the survival and growth of their kids[J]. J Dairy Sci, 2021, 104(4):4970-4979. |
[86] | INDU S, SEJIAN V, NAQVI S M K, et al. Impact of simulated semiarid tropical environmental conditions on growth, physiological adaptability, blood metabolites and endocrine responses in Malpura ewes[J]. Anim Prod Sci, 2014, 55(6):766-776. |
[87] | DIGBY S N, MASTERS D G, BLACHE D, et al. Reproductive capacity of Merino ewes fed a high-salt diet[J]. Animal, 2008, 2(9):1353-1360. |
[88] | ÁLVAREZ D, CARO M R, BUENDÍA A J, et al. Effect of female sex hormones on the developmental cycle of Chlamydia abortus compared to a penicillin-induced model of persistent infection[J]. BMC Vet Res, 2019, 15(1):259. |
[89] | RAHMAN A N M A. Hormonal changes in the uterus during pregnancy-lessons from the Ewe:a review[J]. J Agric Rur Dev, 2006, 4(1):1-7. |
[90] | BEASLEY A M, KAHN L P, WINDON R G. The periparturient relaxation of immunity in Merino ewes infected with Trichostrongylus colubriformis:endocrine and body compositional responses[J]. Vet Parasitol, 2010, 168(1-2):51-59. |
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