HA蛋白位点变异影响H7N9亚型流感病毒特性的研究进展

doi:10.11843/j.issn.0366-6964.2021.08.003

摘要/Abstract

摘要： 2013年春，我国首次出现人感染H7N9亚型禽流感疫情，对家禽养殖和公众健康均产生了严重危害，并且在第5波流行期又演变出血凝素（hemagglutinin，HA）蛋白裂解位点处存在插入突变的高致病性禽流感病毒株。HA作为A型流感病毒表面表达丰度最高的糖蛋白，在介导病毒与宿主细胞表面受体的结合、促进病毒囊膜与细胞膜的融合、刺激机体产生中和抗体等方面具有至关重要的作用。本文围绕H7N9病毒，简要综述了HA蛋白的结构与功能，及其关键功能氨基酸位点变异影响病毒生物学特性的研究进展，以期为深入解析HA蛋白在H7N9病毒感染致病中的作用提供重要参考。

关键词: 流感病毒, H7N9, HA蛋白, 功能氨基酸位点, 感染与致病

Abstract: In the spring of 2013, human infections with H7N9 subtype avian influenza emerged in China, posing serious threats to both poultry farming and public health. Additionally, highly pathogenic H7N9 variants with insertional mutation at the cleavage site of hemagglutinin (HA) protein yet evolved during the fifth epidemic wave. As the most abundantly expressed glycoprotein on the surface of influenza A virus, HA protein plays crucial roles in the viral lifecycle such as mediating the linkage between virus and host cell surface receptors, promoting the fusion between viral envelope and cell membrane, and stimulating the production of neutralizing antibodies. In this review, we briefly summarized the structure and function of HA protein, and the research progress of functional amino acid variations effecting on H7N9 biological properties, in order to provide important reference for in-depth analysis of the role of HA protein in H7N9 infection and pathogenesis.

Key words: influenza virus, H7N9, HA protein, functional amino acid sites, infection and pathogenesis

中图分类号:

S852.659.5

严雅瑶, 顾敏, 刘秀梵. HA蛋白位点变异影响H7N9亚型流感病毒特性的研究进展[J]. 畜牧兽医学报, 2021, 52(8): 2093-2106.

YAN Yayao, GU Min, LIU Xiufan. Advance in the Influence of Amino Acid Variation in HA Protein on the Biological Properties of H7N9 Subtype Influenza Virus[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2093-2106.

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