全基因组SNP分型策略及基因组预测方法的研究进展

doi:10.11843/j.issn.0366-6964.2020.02.001

摘要/Abstract

摘要： 单核苷酸多态性（single nucleotide polymorphism，SNP）是遗传学研究中重要的材料。近年来，全基因组SNP标记开发方法的发展使得研究者们能够以较低成本获得丰富的基因组标记，大大推动了基因组水平的相关研究。基因组预测从已知基因型数据和表型数据的个体建立训练模型，对未知表型的个体进行基因型和表型预测，在育种领域具有重要意义。全基因组SNP的分型策略结合基因组预测方法，构成了动物基因组选择的前沿。本文从这两个方面进行综述，以期为从事分子遗传学，尤其是复杂性状研究的研究者们提供参考。

关键词: 单核苷酸多态性, 基因分型, 基因组预测

Abstract: Single nucleotide polymorphism(SNP) are the important material of genetics research. In recent years, progress in the development of SNP genotyping methods provided the low-cost approach for researchers to obtain large volumes of genomic markers, and promoted the related research at genomic level. Genomic prediction constructs models from individuals with known phenotype and genotype data to predict genotype and phenotype of the individuals with unknown phenotype. It is of great importance in animal breeding. The combination of genomic-wide SNP genotyping and genomic prediction methods constitute the frontier of animal genomic selection. In this paper, we reviewed the advancements of the both methods, it will provide a reference for researchers working in molecular genetics, especially in complex traits.

Key words: single nucleotide polymorphism, genotyping, genomic prediction

中图分类号:

S811.3

王琦, 朱迪, 王宇哲, 吴杰, 胡晓湘, 赵毅强. 全基因组SNP分型策略及基因组预测方法的研究进展[J]. 畜牧兽医学报, 2020, 51(2): 205-216.

WANG Qi, ZHU Di, WANG Yuzhe, WU Jie, HU Xiaoxiang, ZHAO Yiqiang. Research Progress of Genomic-wide SNP Genotyping and Genomic Prediction Methods[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(2): 205-216.

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