(1.Key Laboratory of Animal Genetics，Breeding and Reproduction，Ministry of Agriculture & National Engineering Laboratory for Animal Breeding，College of Animal Science and Technology，China Agricultural University，Beijing 100193，China；2.Chongqing Animal Husbandry Techniques Extension Center，Chongqing 401121， China；3.College of Food Science and Engineering，Northwest A&F University，Yangling 712100， China)
SONG Min-yan，WEI Yi-yuan，Muhammad Zahoor Khan，WANG Xin，YU Ying. Molecular Marker Study of Inflammatory Reaction in Bovine Mammary Epithelium Cell Line Induced by Methicillin-Resistant Staphylococcus aureus[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(10): 1995-2002.
［1］BARBER M.Methicillin-resistant Staphylococci［J］.J Clin Pathol，1961，14：385-393.
［2］FRANCIS J S，DOHERTY M C，LOPATIN U，et al.Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes［J］.Clin Infect Dis，2005，40(1)：100-107.
［3］FERNANDES DOS SANTOS F，MENDONCA L C，REIS D R，et al.Presence of mecA-positive multidrug-resistant Staphylococcus epidermidis in bovine milk samples in Brazil［J］.J Dairy Sci，2015，99(2)：1374-1382.
［4］GUNAWARDANA S，THILAKARATHNE D，ABEGUNAWARDANA I S，et al.Risk factors for bovine mastitis in the Central Province of Sri Lanka［J］.Trop Anim Health Prod，2014，46(7)：1105-1112.
［5］WANG X，WANG X，WANG Y，et al.Antimicrobial resistance and toxin gene profiles of Staphylococcus aureus strains from Holstein milk［J］.Lett Appl Microbiol，2014，58(6)：527-534.
［6］VILASACK T，DOMINIQUE M，OLAF S.Staphylococcu saureus degrades neutrophil extracellular traps to promote immune cell death［J］.Science，2013，342(6160)：863-866.
［7］马裴裴，俞英，张沅，等.中国荷斯坦牛SCC变化规律及其与产奶性状之间的关系［J］.畜牧兽医学报，2010，41(12)：1529-1535.
MA P P，YU Y，ZHANG Y，et al.The distribution of SCC and its correlation with milk production traits in Chinese Holsteins［J］.Acta Veterinaria et Zootechnica Sinica，2010，41(12)：1529-1535.(in Chinese)
［8］WANG X，MA P P，LIU J F，et al.Genome-wide association study in Chinese Holstein cows reveal two candidate genes for somatic cell score as an indicator for mastitis susceptibility［J］.BMC Genet，2015，16(111)：1-9.
［9］董易春，刘超，王晓，等.基于GWAS后分析策略研究TRAPPC9基因对奶牛产奶性状的遗传效应［J］.畜牧兽医学报，2015，46(1)：60-68.
DONG Y C，LIU C，WANG X，et al.Confirmaing the genetic effects of bovine TRAPPC9 on milk production traits based on post-GWAS strategies［J］.Acta Veterinaria et ZootechnicaSinica，2015，46(1)：60-68.(in Chinese)
［10］USMAN T，YU Y，LIU C，et al.Genetic effects of single nucleotide polymorphisms in JAK2 and STAT5A genes on susceptibility of Chinese Holsteins to mastitis［J］.Mol BiolRep，2014，41(12)：8293-8301.
［11］HU W H，PENDERGAST J S，MO X M，et al.NIBP，a novel NIK and IKKβ-binding protein that enhances NF-κB activation［J］.J Gen Virol，2005，280(32)：29233-29241.
［12］KARIN M，GRETEN F R.NF-kappaB：linking inflammation and immunity to cancer development and progression［J］.Nat Rev Immunol，2005，5(10)：749-759.
［13］JAMES C，UGO V，CASADEVALL N，et al.A JAK2 mutation in myeloproliferative disorders：Pathogenesis and therapeutic and scientific prospects［J］.Trends Mol Med，2005，11(12)：546-554.
［14］YUDKIN J S，KUMARI M，HUMPHFIES S E，et al.Inflammation，obesity，stress and coronary heart disease：is interleukin-6 the link?［J］.Atherosclerosis，2000，148(2)：209-214.
［15］ROBERTO P F，LINDHOLM B，AXELSSON J，et al.Update on interleukin 6 and its role in chronic renal failure［J］.Nephrol Dial Transp lant，2003，18(6)：1042-1045.
［16］ZHANG K，SPARLING J，CHOW B L，et al.New quadriplex PCR assay for detection of methicillin and mupirocin resistance and simultaneous discrimination of Staphylococcusaureus from coagulase-negative staphylococci［J］.J Clin Microbiol，2004，42(11)：4947-4955.
［17］FOURNIER B，PHILPOTT D J.Recognition of Staphylococcus aureus by the innate immune system［J］.Clin Microbiol Rev，2005，18(3)：521-540.
［18］KATAYAMA Y，ITO T，HIRAMATSU K.A new class of genetic element，Staphylococcus cassette chromosome mec，encodes methicillin resistance in Staphylococcus aureus［J］.Antimicrob Agents Chemother，2000，44(6)：1549-1555.
［19］王晓，俞英.中国北方奶牛金葡菌乳房炎感染现状及耐药性和流行类型研究进展［J］.畜牧兽医学报，2015，46(9)：1477-1488.
WANG X，YU Y.Infectious status of mastitis in dairy cattle induced by Staphylococcus aureus and its advances on epidemiological patterns and antimicrobial resistance in Northern China［J］.Acta Veterinaria et Zootechnica Sinica，2015，46(9)：1477-1488.(in Chinese)
［20］SACHER M，KIM Y G，LAVIE A，et al.The TRAPP complex：insights into its architecture and function［J］.Traffic，2008，9(12)：2032-2042.
［21］王晓铄，俞英.表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景［J］.遗传，2010，32(7)：663-669.
WANG X S，YU Y.Regulation mechanisms of epigenetics on inflammation and its perspective on breeding for mastitis resistance in dairy cattle［J］.Hereditas (Beijing)，2010，32(7)：663-669.(in Chinese)
［22］冯文，董易春，王晓，等.TRAPPC9基因对奶牛金葡菌乳房炎抗性性状的遗传效应［J］.畜牧兽医学报，2016，47（2）：276-283.
FENG W，DONG Y C，WANG X，et al.The genetic effect of TRAPPC9 on mastitis resistance to S.aureus in Dairy cows［J］.Acta Veterinaria et Zootechnica Sinica，2016，47(2)：276-283.(in Chinese)
［23］ROGHMANN M，TAYLOR K L，GUPTE A，et al.Epidemiology of capsular and surface polysaccharide in Staphylococcus aureus infections complicated by bacteraemia［J］.J Hosp Infect，2005，59(1)：27-32.
［24］JONES G M，PEARSON R E，CLABAUGH G A，et al.Relationships between somatic cell counts and milk production［J］.J Dairy Sci， 1984，67(8)：1823-1831.
