系统发育谱法研究牛蛋白质相互作用网络

ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2011, Vol. 42 ›› Issue (1): 8-17.

• 遗传繁育 • Previous Articles Next Articles

The Study of Protein Interaction Network of Cattle Based on the Phylogenetic Profile

SHEN Qing-hang^1，2, XU Jia-bao³, JIANG Ming-feng^1，2*, ZHONG Jin-cheng^1，2

1. Key Laboratory of Animal Genetics and Breeding, State Ethnic Affairs Commission and Ministry of Education, Chengdu 610041, China; 2. College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China; 3. College of Life Science, Sichuan University, Chengdu 610064, China

Received:1900-01-01 Revised:1900-01-01 Online:2011-01-25 Published:2011-01-25

Abstract

Abstract: The objective of this study was to study the protein interaction network of cattle based on the phylogenetic profile and to provide useful information for the post-genome program of cattle, and the results could be used in production of cattle. The known protein-protein interaction (PPI) data set of C.elegans, S.cerevisiae and Homo sapien were used to deduce the PPI of cattle based on phylogenetic profile in this paper. A PPI network of cattle which included 2 953 proteins and 3 034 interactions was obtained. The analysis of PPI network showed that it was a scale-free property network and 23 unknown proteins including ENSBTAP00000011562 were annotated. The results showed that the partial network related to proteins of lipid metabolism was analyzed based on the known protein information. The result provide effective information for improving the quality and production of milk.

Key words: cattle, protein interaction, interaction network, function prediction, lipid metabolism

SHEN Qing-hang;XU Jia-bao;JIANG Ming-feng;ZHONG Jin-cheng;. The Study of Protein Interaction Network of Cattle Based on the Phylogenetic Profile[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2011, 42(1): 8-17.

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The Study of Protein Interaction Network of Cattle Based on the Phylogenetic Profile

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