ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2009, Vol. 40 ›› Issue (7): 1097-1100.doi:

• 基础兽医 • Previous Articles     Next Articles

Study on Targeting of Tilmicosin Gelatine Microsphere in Rabbits

YUAN Liguo 1,2, LI Chengming 3, BAO Jie 4, ZHU Lixiang 2， ZHANG Xiuying 1*   

  1. 1.College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China；2.College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China； 3.Jiamusi Suburban Husbandry Bureau, Jiamusi 54004, China； 4.Beijing Animal Sanitary Control Station, Beijing 100044, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-07-24 Published:2009-07-24
  • Contact: ZHANG Xiuying

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Abstract: The purpose of this study was to evaluate tilmicosin gelatine microsphere targeting. The timed tilmicosin concentrations of organs from tilmicosin gelatine microsphere and injection administered rabbits were detected with high performance liquid chromatography, and the area under curve was calculated with no compartment model by 3p97, a software of pharmacokinetics. Targeting parameters of tilmicosin gelatine microsphere were analysed. Compared with tilmicosin injection, lung targeting efficiency to heart′s, muscle′s, liver′s and kidney′s was elevated by 518±013, 311±006, 394±006, 374±002 times, respectively. Relative intake rate of lung, heart, muscle, liver and kidney was 823±004, 159±003, 265±004, 209±002 and 220±001. The ratio of peak concentration of lung, heart, muscle, liver and kidney was 222±004, 042±002, 046±001, 061±002 and 071±002, respectively. It was concluded that tilmicosin gelatine microsphere had better lung targeting and alleviated the tilmicosininduced cardiotoxicity.