关键词: 北黄花菜根, 萱草根素, 中枢神经, 病理学, 家兔

Abstract: Pathological studies on central nerve of rabbits induced by hemerocallin were carried out. Hemerocallin was extracted from the roots of Hemerocallis lilioasphodelus L., and suspensoided with 1% starch solution to the concentration of 2%. The suspension was drenched to the experimental rabbits with 4 mL/kg, while control rabbits were treated with 1% starch solution respectively everyday. On the fourth day after treatment, nerve fibers of cerebrum, cerebellum, spinal cord and optic nerve of experimental rabbits began to demyelinate, and the pathological changes in the cerebellum spread from the center of the white matter to the circumference, while reversed in spinal cord, finally they all took on fasciculus vascularis luffae changes. From the seventh day, Purkinje’s cells and neuron of spinal cord began to appear pycnosis and necroses. On the tenth day, neuron of cerebrum also took on the same pathological changes, then dead neuron were phagocytosed by colloid cells, and layer of retina became thin, retinal ganglion cells pyknosis were found, and then disappeared. On ultrastructural level, myelin sheath became loose，broken and lost primary compact structure；Bioblast of nerve cells were intumesced, meanwhile, chondriosome were swelled, dissolved, disappeared, existing many vacuoles; Rough endoplasmic reticulum were dilated and changed in structure. This research proved that hemerocallin can hurt nerve fibers and nerve cells seriously, and cause cecity and death at last.

Key words: Hemerocallis lilio-asphodelus L.roots, hemerocallin, central nerve, pathology, rabbit