基因间长链非编码RNA在骨骼肌发育中的研究进展

doi:10.11843/j.issn.0366-6964.2019.03.001

摘要/Abstract

摘要：

骨骼肌是肉用动物机体最重要的组成部分，维持机体运动并为人类提供生活必需的肉产品，骨骼肌生长发育过程中调控机制的不同会引起肌肉产量和肉品质的差异。基因间长链非编码RNA（long intergenic noncoding RNA，lincRNA）是一类位于基因间区，具有较低蛋白编码潜能的长度大于200 nt的RNA。lincRNA的表达具有时空特异性和组织特异性，在表观遗传调控、转录调控以及转录后调控等多个方面发挥生物学功能。近年来，高通量RNA-seq技术的迅猛发展已经鉴定出了许多与骨骼肌发育相关的lincRNAs，人和小鼠等模式生物研究表明，lincRNA参与调控骨骼肌生长发育、肌细胞的生长增殖、迁移、分化和凋亡等各个环节。本文综述了lincRNA的进化保守性、与mRNAs相比lincRNA的特征、lincRNA在骨骼肌发育中的调控机制及其在畜禽中的研究进展。

关键词: lincRNA, 保守性, 骨骼肌发育, 调控机制

Abstract:

Skeletal muscle is the most important part of the animal body, maintaining the body movement and providing human with the necessary meat products. The difference in the regulatory mechanisms during skeletal muscle growth and development can cause differences in muscle yield and meat quality. Long intergenic noncoding RNA (lincRNA) is a class of RNA located in the intergenic region, which is longer than 200 nt and has a lower protein-encoding potential. The expression of lincRNA has space-time specificity and tissue specificity, and exerts biological functions in epigenetic regulation, transcriptional regulation and post-transcriptional regulation.In recent years, the popular high-throughput RNA-seq technology has identified a number of lincRNA associated with skeletal muscle development, model organism studies such as human and mouse have shown that lincRNA is involved in the regulation of skeletal muscle growth and development, muscle cell growth and proliferation, migration, differentiation and apoptosis. In this review,we summarized the evolutionary conservation,the characteristics of lincRNA, and its research progress in the regulation of skeletal muscle development and domestic animal.

Key words: lincRNA, conservation, skeletal muscle development, regulatory mechanism

中图分类号:

S813.1

鲍晶晶, 浦亚斌, 马月辉, 赵倩君. 基因间长链非编码RNA在骨骼肌发育中的研究进展[J]. 畜牧兽医学报, 2019, 50(3): 461-473.

BAO Jingjing, PU Yabin, MA Yuehui, ZHAO Qianjun. Research Progress of Long Intergenic Noncoding RNA in Skeletal Muscle Development[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(3): 461-473.

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