炎性小体的激活机制及其在机体抗结核分枝杆菌中的作用研究进展

doi:10.11843/j.issn.0366-6964.2020.01.004

Abstract

Abstract: Tuberculosis (TB) is caused by the infection of Mycobacterium tuberculosis (Mtb). It is a severe pulmonary disease and an important public health burden at present. It is estimated that about 23% of the world's population is infected with Mtb. Although many Mtb-infected people do not eventually develop active TB disease, there is still millions of people die of TB worldwide every year. Great effort has been made to reveal the pathogenic mechanism of Mtb in order to ultimately overcome TB. The inflammasomes are a group of polyprotein complexes that accumulate in the cytoplasm of infected or damaged cells. Inflammasomes can recognize pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). So, inflammasomes play important roles in the host defense against many infectious diseases. In this review, we summarized the activation mechanism of inflammasomes and the research progress on the roles of inflammasomes in the host defense against Mtb infection.

Key words: tuberculosis, Mycobacterium tuberculosis, inflammasome, activation

CLC Number:

WANG Jianhong, XU Zhaokun, LI Wu. Mechanisms of Inflammasome Activation and the Research Progresses on the Roles of Inflammasomes in the Host Defense against Mycobacterium tuberculosis Infection[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(1): 27-34.

References 54

[1]	LERNER T R, BOREL S, GUTIERREZ M G. The innate immune response in human tuberculosis[J]. Cell Microbiol, 2015, 17(9):1277-1285.
[2]	SHAH S, BOHSALI A, AHLBRAND S E, et al. Cutting edge:Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system[J]. J Immunol, 2013, 191(7):3514-3518.
[3]	WELIN A, EKLUND D, STENDAHL O, et al. Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1-and cathepsin B-independent necrosis[J]. PLoS One, 2011, 6(5):e20302.
[4]	SEVEAU S, TURNER J, GAVRILIN M A, et al. Checks and balances between autophagy and inflammasomes during infection[J]. J Mol Biol, 2018, 430(2):174-192.
[5]	MASTROCOLA R, ARAGNO M, ALLOATTI G, et al. Metaflammation:tissue-specific alterations of the NLRP3 inflammasome platform in metabolic syndrome[J]. Curr Med Chem, 2018, 25(11):1294-1310.
[6]	SOKOLOVA M, SAHRAOUI A, HØYEM M, et al. NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction[J]. Am J Physiol Endocrinol Metab, 2018, 315(5):E912-E923.
[7]	KARKI R, MAN S M, KANNEGANTI T D. Inflammasomes and cancer[J]. Cancer Immunol Res, 2017, 5(2):94-99.
[8]	AHN H, KWON H M, LEE E, et al. Role of inflammasome regulation on immune modulators[J]. J Biomed Res, 2018, 32(6):401-410.
[9]	KUMAR S, DHIMAN M. Inflammasome activation and regulation during Helicobacter pylori pathogenesis[J]. Microb Pathog, 2018, 125:468-474.
[10]	MARIM F M, FRANCO M M C, GOMES M T R, et al. The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection[J]. Semin Immunopathol, 2017, 39(2):215-223.
[11]	CAI X, CHEN J Q, XU H, et al. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation[J]. Cell, 2014, 156(6):1207-1222.
[12]	LU A, MAGUPALLI V G, RUAN J B, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes[J]. Cell, 2014, 156(6):1193-1206.
[13]	SBORGI L, RAVOTTI F, DANDEY V P, et al. Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy[J]. Proc Natl Acad Sci U S A, 2015, 112(43):13237-13242.
[14]	MALIK A, KANNEGANTI T D. Inflammasome activation and assembly at a glance[J]. J Cell Sci, 2017, 130(23):3955-3963.
[15]	JIN T C, CURRY J, SMITH P, et al. Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1[J]. Proteins, 2013, 81(7):1266-1270.
[16]	VAN OPDENBOSCH N, GURUNG P, WALLE L V, et al. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation[J]. Nat Commun, 2014, 5(1):3209.
[17]	MATUSIAK M, VAN OPDENBOSCH N, LAMKANFI M. CARD-and pyrin-only proteins regulating inflammasome activation and immunity[J]. Immunol Rev, 2015, 265(1):217-230.
[18]	BOSSERMAN R E, CHAMPION P A. ESX systems and the mycobacterial cell envelope:what's the connection[J]. J Bacteriol, 2017, 199(17):e00131-17.
[19]	WONG K W. The role of ESX-1 in Mycobacterium tuberculosis pathogenesis[J]. Microbiol Spectr, 2017, 5(3),
[20]	MITTAL E, SKOWYRA M L, UWASE G, et al. Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response[J]. mBio, 2018, 9(6):e01765-18.
[21]	ABDALLAH A M, WEERDENBURG E M, GUAN Q T, et al. Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator[J]. PLoS One, 2019, 14(1):e0211003.
[22]	MAJLESSI L, PRADOS-ROSALES R, CASADEVALL A, et al. Release of mycobacterial antigens[J]. Immunol Rev, 2015, 264(1):25-45.
[23]	ABDALLAH A M, BESTEBROER J, SAVAGE N D L, et al. Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation[J]. J Immunol, 2011, 187(9):4744-4753.
[24]	ABLASSER A, DORHOI A. Inflammasome activation and function during infection with Mycobacterium tuberculosis[M]//BACKERT S. Inflammasome Signaling and Bacterial Infections. Cham:Springer, 2016, 397:183-197.
[25]	WASSERMANN R, GULEN M F, SALA C, et al. Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1[J]. Cell Host Microbe, 2015, 17(6):799-810.
[26]	HALLE A, HORNUNG V, PETZOLD G C, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β[J]. Nat Immunol, 2008, 9(8):857-865.
[27]	LIU X, LIEBERMAN J. A mechanistic understanding of pyroptosis:the fiery death triggered by invasive infection[J]. Adv Immunol, 2017, 135:81-117.
[28]	RATHINAM V A K, FITZGERALD K A. Inflammasome complexes:emerging mechanisms and effector functions[J]. Cell, 2016, 165(4):792-800.
[29]	DOS SANTOS G, KUTUZOV M A, RIDGE K M. The inflammasome in lung diseases[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 303(8):L627-L633.
[30]	高泽乾,朱学亮,张志东,等. 病毒感染激活炎症小体的分子机制[J]. 畜牧兽医学报, 2016, 47(11):2167-2174.GAO Z Q, ZHU X L, ZHANG Z D, et al. The mechanisms of inflammasomes activation by viral components[J]. Acta Veterinaria et Zootechnica Sinica, 2016, 47(11):2167-2174.(in Chinese)
[31]	SHI H X, WABF Y, LI X H, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component[J]. Nat Immunol, 2016, 17(3):250-258.
[32]	WAWROCKI S, DRUSZCZYNSKA M. Inflammasomes in Mycobacterium tuberculosis-driven immunity[J]. Can J Infect Dis Med Microbiol, 2017, 2017:2309478.
[33]	HE Y, ZENG M Y, YANG D H, et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux[J]. Nature, 2016, 530(7590):354-357.
[34]	HORNUNG V, BAUERNFEIND F, HALLE A, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization[J]. Nat Immunol, 2008, 9(8):847-856.
[35]	SORBARA M T, GIRARDIN S E. Mitochondrial ROS fuel the inflammasome[J]. Cell Res, 2011, 21(4):558-560.
[36]	HEID M E, KEYEL P A, KAMGA C, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation[J]. J Immunol, 2013, 191(10):5230-5238.
[37]	AMARAL E P, RITEAU N, MOAYERI M, et al. Lysosomal cathepsin release is required for NLRP3-inflammasome activation by Mycobacterium tuberculosis in infected macrophages[J]. Front Immunol, 2018, 9:1427.
[38]	YANG Y, ZHOU X M, KOUADIR M, et al. The AIM2 inflammasome is involved in macrophage activation during infection with virulent Mycobacterium bovis strain[J]. J Infect Dis, 2013, 208(11):1849-1858.
[39]	HUANG S H, SONG Z, HUANG Q T, et al. AIM2 inflammasome is critical for dsDNA-induced IL-1β secretion in human dental pulp cells[J]. Inflammation, 2018, 41(2):409-417.
[40]	MAYER-BARBER K D, ANDRADE B B, OLAND S D, et al. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk[J]. Nature, 2014, 511(7507):99-103.
[41]	MAYER-BARBER K D, ANDRADE B B, BARBER D L, et al. Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection[J]. Immunity, 2011, 35(6):1023-1034.
[42]	DORHOI A, IANNACCONE M, FARINACCI M, et al. MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment[J]. J Clin Invest, 2013, 123(11):4836-4848.
[43]	MAYER-BARBER K D, BARBER D L, SHENDEROV K, et al. Caspase-1 independent IL-1β production is critical for host resistance to Mycobacterium tuberculosis and does not require TLR signaling in vivo[J]. J Immunol, 2010, 184(7):3326-3330.
[44]	MCELVANIA TEKIPPE E, ALLEN I C, HULSEBERG P D, et al. Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1[J]. PLoS One, 2010, 5(8):e12320.
[45]	DORHOI A, NOUAILLES G, JÖRG S, et al. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis[J]. Eur J Immunol, 2012, 42(2):374-384.
[46]	FERNANDES-ALNEMRI T, YU J W, JULIANA C, et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis[J]. Nat Immunol, 2010, 11(5):385-393.
[47]	NETEA M G, VAN DE VEERDONK F L, VAN DER MEER J W M, et al. Inflammasome-independent regulation of IL-1-family cytokines[J]. Annu Rev Immunol, 2015, 33:49.
[48]	DE TORRE-MINGUELA C, MESA DEL CASTILLO P, PELEGRÍN P. The NLRP3 and pyrin inflammasomes:implications in the pathophysiology of autoinflammatory diseases[J]. Front Immunol, 2017, 8:43.
[49]	CHOI A J S, RYTER S W. Inflammasomes:molecular regulation and implications for metabolic and cognitive diseases[J]. Mol Cells, 2014, 37(6):441-448.
[50]	LUKENS J R, DIXIT V D, KANNEGANTI T D. Inflammasome activation in obesity-related inflammatory diseases and autoimmunity[J]. Discov Med, 2011, 12(62):65-74.
[51]	GURUNG P, KANNEGANTI T D. Autoinflammatory skin disorders:the inflammasomme in focus[J]. Trends Mol Med, 2016, 22(7):545-564.
[52]	DEMIDOWICH A P, DAVIS A I, DEDHIA N, et al. Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation[J]. Med Hypotheses, 2016, 92:67-73.
[53]	TOBIN D M, ROCA F J, OH S F, et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections[J]. Cell, 2012, 148(3):434-446.
[54]	NETEA M G, SIMON A, VAN DE VEERDONK F, et al. IL-1β processing in host defense:beyond the inflammasomes[J]. PLoS Pathog, 2010, 6(2):e1000661.

Mechanisms of Inflammasome Activation and the Research Progresses on the Roles of Inflammasomes in the Host Defense against Mycobacterium tuberculosis Infection

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