ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2018, Vol. 49 ›› Issue (10): 2092-2101.doi: 10.11843/j.issn.0366-6964.2018.10.005

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Effects of Particulate Matter from Pig House on Alveolar Macrophage

TANG Qian, DAI Peng-yuan, WU Sheng, SHEN Dan, LI Yan-sen, LI Chun-mei*   

  1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
  • Received:2018-02-27 Online:2018-10-23 Published:2018-10-23

Abstract:

Particulate matter (PM) from pig houses is closely related to pig's health status and production performance and it is one of the important reasons for causing respiratory diseases in pigs. PM from pig houses carry many toxic and harmful substances, such as endotoxin, heavy metals, pathogenic bacteria and so on, thus the PM is more complex and toxic. PM can induce inflammatory response in lung, but the exact mechanism is still unclear. Alveolar macrophage, a kind of free immune cells in lung, play a major role in clearing and processing PM. Firstly, the characteristics and components of PM were put forward. Then the effect of PM on growth performance and respiratory health of pigs was described. Lastly, the effect of PM on alveolar macrophage function and its regulatory mechanisms was focused on. PM can influence the innate immunity of alveolar macrophage by reducing its phagocytic capacity, altering cell polarization and activating TLR4-NF-κB/AP-1 signaling pathway, and it can also function as antigen-presenting cells to initiate adaptive immune responses. In summary, this review provide the theoretical basis for studying PM from pig houses.

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