ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2018, Vol. 49 ›› Issue (10): 2070-2079.doi: 10.11843/j.issn.0366-6964.2018.10.002

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Trans-splicing and Its Roles in Mammals

JING Xiao-yan1, ZHANG Cai-xia1, SONG Yan-fang1, LIU Dong-yu1, LIU Di2, YANG Xiu-qin1*   

  1. 1. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China;
    2. Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China
  • Received:2018-03-23 Online:2018-10-23 Published:2018-10-23

Abstract:

Trans-splicing(TS) is the process by which two or more pre-mRNA molecules are spliced to form a mature mRNA, a way to produce chimeric RNAs at the post-transcriptional level. TS research started late, but the development of high-throughput sequencing and bioinformatics technologies has provided the effective means for related research. Along with the identification of a large number of TS and its chimeric RNAs, it has been found that TS can produce new functional products-fusion proteins or regulatory non-coding RNAs, also can affect parental genes expression only by competitive use of the parental pre-mRNA, which play important role in physiological activities and diseases. This article reviews the TS definition, type, production mechanism and its role in mammals, in order to provide a reference for completely understanding the research situation and development trend of TS.

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