ZHANG Jun-zhen，JI Kai-yuan，SHI Zhan-quan，LIU Yu，HU Shuai-peng，FAN Rui-wen. The Effect of lpa-miR-nov-66 on CDK5 Phosphorylation in Alpaca Melanocyte[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(2): 290-295.
［1］TIAN X，JIANG J，FAN R，et al.Identification and characterization of microRNAs in white and brown alpaca skin［J］.BMC Genomics， 2012，13：555.
［2］YANG S，FAN R，SHI Z，et al.Identification of a novel microRNA important for melanogenesis in alpaca (Vicugna pacos)［J］.J Anim Sci，2015，93(4)：1622-1631.
［3］GESELLCHEN F，STANGHERLIN A，SURDO N，et al.Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors［J］.Methods Mol Biol，2011，746：297-316.
［4］DHARIWALA F A，RAJADHYAKSHA M S.An unusual member of the Cdk family：Cdk5［J］.Cell Mol Neurobiol，2008，28(3)：351-369.
［5］FAN R，DONG Y，CAO J，et al.Gene expression profile in skin of white alpaca (Lama pacos)［J］.Animal，2011，5 (8)：1157-1161.
［6］刘佳，董常生，范瑞文，等.周期素依赖性蛋白激酶-5在不同毛色羊驼皮肤中的表达［J］.畜牧兽医学报，2010，41(4)：478-483.
LIU J，DONG C S，FAN R W，et al.Expression of cyclin dependent kinase 5 in alpaca skin of different hair colors［J］.Acta Veterinaria et Zootechnica Sinica，2010，41(4)：478-483.(in Chinese)
［7］张瑞娜，范瑞文，程志学，等.CDK5对羊驼皮肤黑色素细胞TYR和MITF mRNA 表达的调节［J］.畜牧兽医学报，2011，42(12)：1712-1717.
ZHANG R N，FAN R W，CHENG Z X，et al.Regulation of TYR and MITF mRNA expression by CDK5 in alpaca melanocytes［J］.Acta Veterinaria et Zootechnica Sinica，2011，42(12)：1712-1717.(in Chinese)
［8］BUSCÀ R，BALLOTTI R.Cyclic AMP a key messenger in the regulation of skin pigmentation［J］.Pigment Cell Res，2000，13(2)：60-69.
［9］MOY L Y，TSAI L H.Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability［J］.J Biol Chem，2004，279(52)：54487-54493.
［10］OETTING W S.The tyrosinase gene and oculocutaneous albinism type 1 (OCA1)：a model for understanding the molecular biology of melanin formation［J］.Pigment Cell Res，2000，13(5)：320-325.
［11］XU S，LI X，GONG Z，et al.Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration［J］.Mol Cell Proteomics， 2014，13(11)：2986-3000.
［12］LALIOTI V，PULIDO D，SANDOVAL I V.Cdk5，the multifunctional surveyor［J］.Cell Cycle，2010，9(2)：284-311.
［13］ALIZADEH A，FITCH K R，NISWENDER C M，et al.Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements［J］.Pigment Cell Melanoma Res， 2008，21(1)：63-69.
［14］ORTONNE J P，PROTA G.Hair melanins and hair color：ultrastructural and biochemical aspects［J］. J Invest Dermaltol， 1993，101(1 Suppl)：82S-89S.
［15］LIN J Y，FISHER D E.Melanocyte biology and skin pigmentation［J］.Nature，2007，445(7130)：843-850.
［16］CHELI Y，LUCIANI F，KHALED M，et al.αMSH and cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism［J］.J Biol Chem，2009，284(28)：18699-18706.
［17］GRATTEN J，BERALDI D，LOWDER B V，et al.Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep［J］.Proc Biol Sci，2007，274(1610)：619-626.
［18］GODING C R.Mitf from neural crest to melanoma：signal transduction and transcription in the melanocyte lineage［J］.Genes Dev，2000，14(14)：1712-1728.
［19］STEINGRIMSSON E，COPELAND N G，JENKINS N A.Melanocytes and the microphthalmia transcription factor network［J］. Annu Rev Genet， 2004，38：365-411.
［20］GIEBEL L B，MUSARELLA M A，SPRITZ R A.A nonsense mutation in the tyrosinase gene of Afghan patients with tyrosinase negative (type IA) oculocutaneous albinism［J］.J Med Genet，1991，28(7)：464-467.
［21］SOUTHERN E，MIR K，SHCHEPINOV M.Molecular interactions on microarrays［J］.Nat Genet， 1999，21(1 Suppl)：5-9.
［22］ROESLER W J，PARK E A，MCFIE P J.Characterization of CCAAT/enhancer-binding protein α as a cyclic AMP-responsive nuclear regulator［J］.J Biol Chem，1998，273(24)：14950-14957.
